Sentences with phrase «candidate genes with»

By integrating promoter capture Hi - C data with genetic associations for five autoimmune diseases, we prioritised 245 candidate genes with a median distance from peak signal to prioritised gene of 153 kb.

These include: a) Global Clusters that consist of a small, tight subset of genes that are co-expressed under the entire spectrum of experimental conditions; b) Time Series of gene expression profiles during successive days of standard ES cell differentiation; c) Specific Gene Classes based on hierarchical clustering of transcriptional factors and ESTs; d) Expression Waves of genes with characteristic expression profiles during ES cell differentiation, juxtaposed to waves of genes that behave in the exact opposite way; e) Pathway Animations that illustrate dynamic changes in the components of individual KEGG signaling and metabolic pathways viewed in time - related manner; and, f) Search Engines to display the expression pattern of any transcript, or groups of transcripts, during the course of ES cell differentiation, or to query the association of candidate genes with various FunGenES database clusters.

Perform phenotypic profiling in primary human cells to identify and characterize candidate genes with therapeutic potential,

Therefore, better analytical approaches that enrich the list of candidate genes with authentic cancer - associated «driver» genes are needed.

Not exact matches

The oxytocin receptor is a plausible gene candidate linking the birth experience with maternal - child outcomes.

McCallion's strategy to make sense of all this data looks at the active genes in cells affected by a disease, groups of genes that interact with one another, their vulnerability to mutation and information from past scientific studies to filter more than a thousand gene candidates for disease risk down to just a handful within any one implicated region.

And since a medical condition with an apparent patient population of one could hardly garner federal funding, Rienhoff recast himself as a citizen scientist, a do - it - yourselfer who now finally has a candidate gene in hand.

Working with this hypothesis, the researchers conducted a statistical analysis of the CX3CR1 gene in over 7000 schizophrenia and autism patients and healthy subjects, finding one mutant candidate, a single amino acid switch from alanine to threonine, as a candidate marker for prediction.

The race was on, with the two teams probing for candidate genes in that region to determine which bore the APECED mutations.

«Perhaps as many as 30 percent of schizophrenic patients may now become candidates for more precise treatment based on the individual characteristics of these four genes, with the remaining cases becoming less mysterious as we pull these groups out of the mix,» says Malaspina, the Anita Steckler and Joseph Steckler Professor in the Department of Psychiatry at NYU Langone.

A team led by Margaret Pericak - Vance of Duke University, Jonathan Haines of Vanderbilt University in Nashville, Tennessee, and Allen Roses — a former Duke researcher now in charge of genetics research at the Glaxo Wellcome Company in Research Triangle Park, North Carolina — scanned the DNA of members of 16 large families with a high rate of Alzheimer's, looking at 280 genetic markers that might help identify candidate genes.

And because mouse embryo cells with inactivated copies of BRCA2 are more sensitive to ionizing radiation than normal cells are, «it's a reasonable extrapolation» that breast cancers with mutated copies of the gene may be especially good candidates for radiation therapy.

Starting with a candidate list of 20,000 genes, researchers screened down to eight before singling out VNN - 1 as the primary target.

When they found a good candidate that could deliver genes to rat brain cancer cells, they filled the nanoparticles with DNA encoding an enzyme, herpes simplex virus type 1 thymidine kinase (HSVtk), which turns a compound with little effect into a potent therapy that kills brain cancer cells.

Harris cited other examples of concern — a review of 100 studies in the field of psychology in which the findings in only about a third of the studies were reproducible; an effort by scientists at Bayer, another large drug company, that managed to reproduce the findings of only one - quarter of the studies under review; a just - published review of 25 historical candidate genes for schizophrenia which found no evidence that the candidate genes are more associated with the disease than other genes.

In 2013, Soderling's group selected one of those gene candidates, Arp2 / 3, based on its importance in controlling the formation of synapses — the links between neurons — and its association with multiple neuropsychiatric disorders.

Participants with autism who carry a harmful CNV have lower intelligence quotients than those who carry a harmful mutation in a candidate gene.

Case studies described in the article show how microRNAs may affect voluntary alcohol consumption in mice, candidate genes within signaling pathways associated with chronic obstructive pulmonary disease, and the microRNA: gene interactions that influence bladder cancer.

«With the first families, we had no idea what gene might be causing this disorder, so we did a genome analysis and a good candidate gene screen came in with CLP1,» said KarWith the first families, we had no idea what gene might be causing this disorder, so we did a genome analysis and a good candidate gene screen came in with CLP1,» said Karwith CLP1,» said Karaca.

«These findings suggest that focusing on genes with conserved expression levels among primates may be helpful in identifying promising candidates for disease - association studies,» the researchers write.

A companion paper published in BMC Evolutionary Biology by colleagues at the EPA lab in Narragansett, RI, that used a «candidate gene scan» approach — examining SNPs from 42 genes associated with the AHR pathway — also identified AHR2 as a gene that appears to be under selection and is likely to be involved in the resistance.

Previous genetic studies have examined the association of aspirin, NSAIDs, or both with colorectal cancer according to a limited number of candidate genes or pathways.6 - 10 Thus, to comprehensively identify common genetic markers that characterize individuals who may obtain differential benefit from aspirin and NSAIDs, we conducted a discovery - based, genome - wide analysis of gene × environment interactions between regular use of aspirin, NSAIDs, or both and single - nucleotide polymorphisms (SNPs) in relation to risk of colorectal cancer.

«Scientists don't know what proteins might be involved in magnetite - based magnetoreception, but now we have some candidate genes to work with,» Fitak said.

Furthermore, if transcriptional regulation of adipose tissue function contributes to adiposity - dependent modulation of insulin sensitivity, blood pressure, and other medically important traits, then the genes that correlate with body mass will be candidates for mediating these responses and warrant further evaluation.

In addition, researchers should consider following up with interesting candidate genes by knocking them out individually in mice, Tang says.

We helped with the analysis of targeted 3730 sequencing of some candidate genes in a warfarin patient cohort, and uncovered another gene, (CALU, encoding calumenin) in which variants influenced warfarin dose.

Candidate gene and genome - wide association studies have identified variants associated with HBV - related disease progression or hepatocellular carcinoma in various populations [46][52].

With over 20,000 known protein - coding genes, widespread genetic variation, and the continual accumulation of mutations in somatic tissues, there are plenty of candidates that will meet these criteria by chance alone.

In a study published January in the journal Molecular Biology and Evolution, Gibbs and his team compared the DNA of the fat fruit flies to a control group in the lab and found nearly 400 candidate genes potentially associated with obesity and other health problems.

The researchers particularly identified three novel candidate genes; KIRREL3 and SLIT1, with documented roles in immune cell development, and SERPINA9 expressed exclusively at the site (germinal center) where a B - cell starts producing IgA.

Recovery of ancient DNA, coupled with low - throughput gene candidate analyses, has previously been used to investigate changes in the genetic diversity of horses over time.

I look for genes, pathways, and candidate mutations associated with a disease, in order to understand the mechanism and the etiology of a disease, which may eventually lead to new therapeutic targets.

While TET1 expression was decreased in patients with diabetes (q < 0.15), numerous other candidate genes were only nominally regulated (Supplementary Table 21).

In the sequencing of five candidate genes (LPL, LCAT, ABCA1, PON1, and SERPINE1), rare and common SNPs were identified that were associated with differences in serum lipids.

We selected genes with a weight > 1 as a conservative set of candidate genes.

We also examined whether candidate genes for T2D and / or obesity, previously identified by GWAS (P < 1.0 × 10 − 5 [www.genome.gov/gwastudies]-RRB-, exhibit differential methylation in adipose tissue of unrelated patients with diabetes versus nondiabetic subjects.

Linkage and candidate gene studies have been highly successful in the identification of genes that cause the monogenic variants of diabetes and, although progress in the more common forms of T2D has been slow, a number of genes have now been reproducibly associated with T2D risk in multiple studies.

The approach to target validation utilizes RNAi, CRISPR, and ORF expression platforms to genetically perturb candidate target gene expression in relevant cancer cell lines, and then profile the resulting phenotypic changes with regard to their effect on various biochemical pathways.

As some candidate genes are associated with both obesity and T2D, the differentially expressed candidate genes correspond to 33 unique genes.

This observation suggests that the bulk of genes involved in Nasonia immune response remain uncharacterized, with the current study being the first identification of additional candidate genes for immunity based on functional response to infection.

Despite type 2 diabetes having been well studied by genome - wide association studies in other populations, analysis in Mexican and Latin American individuals identified SLC16A11 as a novel candidate gene for type 2 diabetes with a possible role in triacylglycerol metabolism.

In the past, scientists would pick a candidate gene — such as those implicated in brain development or diabetes — and closely analyze how the gene might be associated with evolution or disease.

An example of a «candidate gene» experiment testing whether different diploid genotypes are associated with different trait values, or phenotypes.

To demonstrate VarScan's capabilities, we used data from a collaboration with Stephen Daiger and colleagues, who are resequencing candidate genes in a cohort of families with Retinitis Pigmentosa (RP).

«We started with candidate gene studies, then moved to common variants and genome wide association studies, and then, most recently, leveraged exome sequencing, he said.

Candidate causal variants were reviewed in IGV, and assessed in the context of databases (like HGMD), segregation, and how well the clinical phenotype matched the phenotype associated with the gene.

Concurrently, the research group is examining how the epigenetic profile of different candidate genes predicts, and perhaps changes, in response to recovery from PTSD (and negative self - cognitions) along with its neural correlates.

Moreover, several candidate genes were associated with male sterility, which is the only hybrid phenotype detected so far in crosses between rabbit subspecies.

The white - footed mice's success is encouraging from a conservation perspective, since the urban mice were starting with a limited gene pool — only half the genetic diversity of country mice, noted Max Lambert, an urban ecologist and doctoral candidate at Yale University in New Haven, Connecticut, who was not involved in the study.

In order to extract the candidates with greatest probability of encoding protein coding genes, we cross-referenced all predicted loci to the Ensembl databases using the API [54].