Sentences with phrase «candidate molecules»

They will test the best candidate molecules in mice to see if they can replicate their study findings, before moving on to human clinical trials.

Over the past couple of decades, the screening of molecules for their active principle has relied greatly on the ability to model candidate molecules before experimental consideration.

This system, along with computer modeling and further tests performed both in and outside of cells, whittled the thousands of candidate molecules down to eight that could bind to SENP2 in cells and were non-toxic.

We hope to use this approach to identify candidate molecules that might represent previously unknown pro-growth signals.

Prior to the deCode acquisition, only 15 % of Amgen candidate molecules had been validated against specific genetic targets.

Researchers at the Center for iPS Cell Research and Application (CiRA), Kyoto University, took advantage of this strategy by reprogramming FOP patient cells and then seeking candidate molecules that could explain how the disease initiates.

Again, after screening many small molecules to see which would best inhibit the PPxY - Nedd4 interaction, the team found two strong candidate molecules.

The group has already identified several candidate molecules which activate GDNF receptors in immortalized cells and shown that one of them promoted survival of dopamineric neurons in vitro.

These collaborations not only allow the creation of candidate molecules and more rapid target discovery, but also help biologists learn how to collect data in ways that help computational scientists analyze the data.

On theoretical grounds, a good candidate molecule would be p70S6K, because, in aggregate, the recently published findings suggest that there is a positive feedback signal from p70S6K to mTOR (43, 44) and from mTOR to AKT (ref.

The review exposed some clear losers; in the case of 5 % of its candidate molecules, there was evidence the agent wouldn't work.

As of today, his team has one «candidate molecule» that they hope to bring into clinical studies within the next 18 months, and a second one that is showing great promise.

The team began by building libraries of more than 1.6 million candidate molecules.

The research, published March 26 in Nature Biomedical Engineering, led to a candidate molecule currently beginning phase 1 clinical trials.

Broadly, the scope of our capabilities include, but are not limited to: (1) determination of optimal route and dose for pathogen challenge, (2) determination of correlates of immunity, (3) standardization of animal models for use in «Proof - of - Concept» efficacy studies of candidate vaccines, therapeutics and immunotherapeutics and (5) toxicity and efficacy of candidate molecules or vaccines in small animal models of infectious disease.

Ultimately, a candidate molecule called ICEC0942 suppressed tumour growth in a wide range of cancer types in lab tests.

The ambition of I - Stem is to develop a research technology capable of covering all aspects of discovery and development of therapeutic molecules for pre-clinical trials as defined by clinical and epidemiological studies of monogenic diseases, until a candidate molecule is identified for clinical trials.

Before treating sperm with progesterone, the researchers exposed them to a chemical that inhibits a particular class of enzymes that they believed could include the candidate molecule that acted on CatSper.