Sentences with phrase «candidate obesity genes»

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In a study published January in the journal Molecular Biology and Evolution, Gibbs and his team compared the DNA of the fat fruit flies to a control group in the lab and found nearly 400 candidate genes potentially associated with obesity and other health problems.

Among differentially expressed obesity and T2D candidate genes (Supplementary Tables 4 and 5), there were significant associations between methylation and expression for 65 sites corresponding to 17 genes (Supplementary Table 20).

Several candidate genes for obesity and T2D (e.g., IRS1 and VEGFA) were differentially expressed in discordant twins.

We also examined whether candidate genes for T2D and / or obesity, previously identified by GWAS (P < 1.0 × 10 − 5 [www.genome.gov/gwastudies]-RRB-, exhibit differential methylation in adipose tissue of unrelated patients with diabetes versus nondiabetic subjects.

Moreover, 127 sites representing 65 candidate genes for obesity were differentially methylated in case - control cohort 2 (q < 0.15, P = 0.5, χ2 test; Supplementary Table 15).

As some candidate genes are associated with both obesity and T2D, the differentially expressed candidate genes correspond to 33 unique genes.