Sentences with phrase «candidate therapeutic drugs»
For now, Rashid's group has a list of candidate therapeutic drugs that they'll test in their new liver disease models, something that may still prove useful to patients.
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A pharmaceutical hit compound, like those discovered by Vogel and her co-authors, is a compound that is a promising candidate for chemical modification so it can eventually be delivered to patients as a therapeutic drug.
Instead of systematically testing the effects of known compounds — the pharmaceutical industry's basic model for more than a century — scientists can now investigate backward, combing through genomic data to find links between specific genotypes and diseases and then screening drug data to identify therapeutic candidates.
The result is a new dual - targeting drug candidate — or, as Griffin describes, «one drug addressing multiple therapeutic indications» — that could treat both diabetes and bone disease.
Drugs that target KORs have shown promise as therapeutic candidates because of their efficacy for treating chronic itch and relieving pain.
Knowing that Notch governs vessel permeability makes it a candidate for new drugs to treat cardiovascular diseases as well, and the team is also investigating the TMD as a potential therapeutic agent itself, as cell models that were exposed to leak - inducing inflammation displayed a dramatic reduction in leakage when they were engineered to express the TMD.
Non-exclusive licenses are available for research and sale of products and services across multiple fields including: research tools, kits, reagents; discovery of novel targets for therapeutic intervention; cell lines for discovery and screening of novel drug candidates; GMP production of healthcare products; production of industrial materials such as enzymes, biofuels and chemicals; and synthetic biology.
Snowdon, Inc. has discovered prospective drug candidates that address the urgent need for safe and effective medicines in three major therapeutic areas — cancer, pain, and infectious diseases.
These forward - looking statements are based on management's current assumptions and expectations and involve risks, uncertainties and other important factors, specifically including those relating to Lexicon's ability to successfully conduct preclinical development of its drug candidates and advance such candidates into clinical development, achieve its operational objectives, obtain patent protection for its discoveries and establish strategic alliances, as well as those relating to manufacturing, the regulatory process, intellectual property rights, and the therapeutic or commercial value of its drug candidates, that may cause Lexicon's actual results to be materially different from any future results expressed or implied by such forward - looking statements.
This can help identify new molecules likely to inhibit certain therapeutic targets and to lead to novel drug candidates.
The company plans to develop and commercialize its innovative mRNA drugs — initially for rare diseases and oncology — while partnering drug candidates in other therapeutic areas in order to rapidly deliver this innovation to patients.
To help Gladstone discoveries successfully cross through the valley of death, the Hellman Family Foundation Alzheimer's Research Program subsidizes the myriad of early - stage, de-risking tests necessary to make a drug candidate more attractive to pharmaceutical - industry partners, such as tests that reveal at what concentrations a drug stops being therapeutic and instead becomes toxic.
Carmot is applying an innovative technology, Chemotype Evolution, to overcome the limitations of conventional discovery technologies and identify superior drug candidates for challenging therapeutic targets.
Carmot is applying a transformative technology, Chemotype Evolution, to overcome the limitations of conventional discovery technologies and to identify superior drug candidates for challenging therapeutic targets.
The Tg5453 mouse model was successfully used in establishing the therapeutic efficacy of Remicade ®, the first anti-TNF therapeutic to be successfully applied in the clinic, and is recommended by the FDA for screening potential anti-rheumatoid candidate drugs.
We currently evaluate the therapeutic benefits as well as the toxicity of drug candidates in spheroids by means of conventional fluorescence microscopy as well as LSFM and many different biochemical and molecular biology - based assays (Ansari et al. 2013; Wenzel et al. 2014; Pampaloni & Stelzer 2010).
An emerging strategy in early drug discovery entails using fragments, i.e. molecules smaller than conventional drug candidates, as starting points for design of novel therapeutic compounds.
Translational medicine is the integrated application of innovative pharmacology tools, biomarkers, clinical methods, clinical technologies and study designs to improve disease understanding, confidence in human drug targets and increase confidence in drug candidates, understand the therapeutic index in humans, enhance cost - effective decision making in exploratory development and increase phase II success.
Researchers report a surprising mechanism through which an important new candidate drug against leukemia exerts its therapeutic effect...
Its products includes of drug candidates of therapeutic areas, including oncology, pain, anti-infectives, anti-viral and immunology.