Sentences with phrase «candidate vaccine viruses»

That includes tracking the myriad flu strains circulating globally each year in animals and using the data to help develop candidate vaccine viruses.

Such GOF studies are «crucial» for the selection of each year's candidate vaccine viruses because they help WHO identify the riskiest strains in the wild, Schultz - Cherry said.

In case it takes a different course, the CDC asked the laboratory that makes candidate vaccine viruses to make one for the swine H3N2.

Not exact matches

And by winter several more vaccine candidates that employ various forms of the virus are slated for human testing, supported by funds from the NIH.

«It was not known whether any of these vaccines could provide protection against the new outbreak West African Makona strain of Ebola Zaire currently circulating in Guinea,» said John Eldridge, Chief Scientific Officer - Vaccines at Profectus Biosciences, Inc. «Our findings show that our candidate vaccines provided complete, single dose protection from a lethal amount of the Makona strain of Ebola virusvaccines could provide protection against the new outbreak West African Makona strain of Ebola Zaire currently circulating in Guinea,» said John Eldridge, Chief Scientific Officer - Vaccines at Profectus Biosciences, Inc. «Our findings show that our candidate vaccines provided complete, single dose protection from a lethal amount of the Makona strain of Ebola virusVaccines at Profectus Biosciences, Inc. «Our findings show that our candidate vaccines provided complete, single dose protection from a lethal amount of the Makona strain of Ebola virusvaccines provided complete, single dose protection from a lethal amount of the Makona strain of Ebola virus.»

«In addition, this platform can be used to develop safe vaccine candidates for other flaviviruses such as Zika virus, where pregnant women are the target group for vaccination.»

Attempts at using live dengue viruses to develop a dengue fever vaccine have often led to an imbalance in immunity to the four dengue serotypes — for instance, one recent candidate had lower efficacy against serotype 2.

The ZPIV vaccine candidate was developed by WRAIR as part of the US Department of Defense response to the 2015 - 2016 outbreak of Zika virus in the Americas, and it was advanced to a Phase 1 trial in November 2016.

Researchers have developed a candidate vaccine against Ebola, one of the world's deadliest viruses.

Gary Nabel, a molecular virologist with the University of Michigan Medical Center in Ann Arbor, and Anthony Sanchez, a virologist at the U.S. Centers for Disease Control and Prevention (CDC) in Atlanta, created their candidate vaccine from snippets of the Ebola virus's DNA.

Prompted by the recent Zika virus outbreaks in Latin America and some parts of the United States, scientists around the world have been racing to develop candidate vaccines.

Prompted by the recent Zika virus outbreaks in Latin America and some parts of the United States, scientists around the world have been racing to develop candidate vaccines, and already several have been tested in animals.

«We observed rapid and durable protective immunity without adverse events, and so we think this candidate vaccine represents a promising strategy for the global fight against Zika virus,» said senior author Drew Weissman, MD, PhD, a professor of Infectious Disease at Penn. «We hope to start clinical trials in 12 to 18 months.»

Some newer vaccine candidates use harmless viruses such as modified adenoviruses to deliver genes that encode immunizing viral proteins.

The new candidate vaccine contains mRNAs encoding two key proteins from a Zika virus strain isolated in a 2013 outbreak.

The new candidate vaccine is the first to show such potent and long - lasting protection without the use of a live virus.

A single immunization with the vaccine candidate produced strong immune responses and prevented the virus from infecting mice at all.

Johns Hopkins Bloomberg School of Public Health researchers say a new candidate vaccine against respiratory syncytial virus (RSV) made with a weakened version of the virus shows great promise at fighting the disease, the leading cause of hospitalization for children under the age of one in the U.S.

«This research team's dedication and previous research on dengue and other arboviruses enabled them to quickly develop this model for Zika virus, an important first step to enable testing of candidate vaccine and therapeutics,» said Stephen Higgs, PhD, the president of the American Society of Tropical Medicine and Hygiene.

The reliably high percentage of those who develop viremia following exposure to this challenge virus is another advantage — when most or all volunteers develop viremia or other signs of infection, clinical trials can enroll relatively small numbers of people but still achieve answers to such questions as whether a candidate vaccine protects against infection, she noted.

The candidate vaccine is made from a mixture of four live, weakened (attenuated) viruses targeted to each of the four serotypes.

In the preclinical study, WRAIR and the Beth Israel Deaconess Medical Center tested two Zika virus vaccine candidates: a DNA vaccine developed at Harvard based on a Zika virus strain isolated in Brazil, and a purified inactivated virus vaccine developed at WRAIR based on a Zika virus strain isolated in Puerto Rico.

«We can identify the mutations that will occur in nature and make those viruses available at the time of vaccine (virus) candidate selection.»

Unlike other candidates, a new potential Zika vaccine is so effective that one shot gives enough protection — a key advance, given the virus is here to stay

In a previously published paper, Barouch and colleagues, including Colonel Nelson L. Michael, MD, PhD, director of the Military HIV Research Program at the Walter Reed Army Institute of Research (WRAIR) and Stephen Thomas, MD, Upstate Medical University, State University of New York, demonstrated that three different vaccine candidates provided robust protection against Zika virus in both mice and rhesus monkeys.

In clinical trials, several candidate H7N9 pandemic influenza vaccines made from inactivated viruses have been shown to be safe and to generate an immune response.

The vaccine candidates rapidly induced antibodies that, in cell culture, neutralised the virus.

DEFENSE Vaccine candidates developed from DNA and proteins of the MERS virus (above, yellow) produced protective immune proteins and reduced lung damage in monkeys six days after infection.

For influenza we offer the ferret model, the «gold standard» for infections with human influenza viruses, which will be used to assess the efficacy of vaccine candidates.

TNA8: BPRC will provide access to macaques for immunogenicity / adjuvanticity evaluation of vaccine candidates for malaria, tuberculosis, HIV, influenza, West Nile virus or dengue virus, with up to three (prime - boost) immunisation events.

Vaccine candidates for preventing SARS have been developed by various groups and include inactivated whole virus, spike (S) protein preparations, virus - like particles (VLPs), plasmid DNA and a number of vectors containing genes for SARS - CoV proteins [13]--[28].

So far, in the 30 years since the AIDS virus was identified, only one vaccine candidate has shown any protection at all, reducing the risk of contracting HIV by 31 percent.

Four candidate vaccines for humans with or without alum adjuvant were evaluated in a mouse model of SARS, a VLP vaccine, the vaccine given to ferrets and NHP, another whole virus vaccine and an rDNA - produced S protein.

His lab has extensive experience evaluating and modulating T cell responses to tumors and viruses, including introducing genes into T cells to impart specificity and modulate function, designing strategies to overcome tolerance and enhance in vivo activity, and developing mouse models that more accurately model human immune responses to candidate vaccines.

They selected the combinations of backbone mutations that supported better growth in cell culture, identifying two candidate backbones that led to higher amounts of vaccine virus.

Last year, his research team created a high - yield influenza A vaccine virus candidate for cell culture production.

2009 — Developed an MVA HIV Vaccine Candidate — MHRP and NIAID researchers developed a new HIV vaccine, specific to the strain of HIV circulating in Southeast Asia that is expressed in a modified smallpox virus vectorVaccine Candidate — MHRP and NIAID researchers developed a new HIV vaccine, specific to the strain of HIV circulating in Southeast Asia that is expressed in a modified smallpox virus vectorvaccine, specific to the strain of HIV circulating in Southeast Asia that is expressed in a modified smallpox virus vector (MVA).

Dr. Jay Nelson stated the first hurdle in testing possible vaccine candidates is determining an appropriate animal model for the Zika virus.

The Delta VP30 technology has been approved by the National Institutes of Health for use under Biosafety Level 2 conditions and has been utilized safely for a decade to study the basic biology of the virus, identify potential antiviral compound candidates, and make the whole - virus vaccine.

Other Ebola vaccine candidates use vector viruses to ferry a single Ebola protein, a surface antigen, to prime the immune system.

Ironically, while pregnant women, elderly, small children and medical workers are thought to be high risk candidates for contracting the virus (and are therefore encouraged to get it), the research is still out on the safety of the vaccine for these categories.

He has also generated attenuated viruses as vaccine candidates, for the treatment of influenza and arenavirus infections in humans and other mammalians.