The findings of this study also have important implications for investigators looking for
canine models for research on various forms of cancer [32], [33].
In a new study published in the journal Scientific Reports, a research team from the University of Pennsylvania School of Veterinary Medicine took a different approach, using
canine models of vision - robbing disorders.
Overmyer's expertise as a technologist is bolstering research with Peter Muir, the Melita Grunow Family Professor in the School of Veterinary Medicine at UW - Madison, who is
using canine models for osteoarthritis, and with Peter G. Shultz at the Scripps Research Institute who is investigating novel therapies in humans.
Because of the similarities in ocular anatomy,
canine models contribute significantly to the understanding of retinal disease mechanisms and the development of new therapies for human patients.
With that in mind, the Penn Vet team chose to examine two of their well -
established canine models of RP, which recapitulate many features of the human diseases, each involving mutations in different genes.
Her research has two main foci, first to understanding the neurobiology and genetics of canine behavior and canine cognition, and second, the development of natural genetic and
behavioral canine models for human psychiatric illness, particularly those involving anxiety, panic, and aggression.
Eva Furrow, PhD Adviser: Dr. Ned Patterson Thesis: Metabolic and Genetic Determinants of Urolithiasis in a
Natural Canine Model.
Although canine models of various cancers garner increasing interest as in vitro systems suitable for studies of basic biology and drug development, the fact that breed specificity is observed for many types of cancer has excited geneticists who are anxious to localize susceptibility genes that have proved intractable in human families and populations.
For approximately 15 months, Roy has visited the animal shelter nearly everyday; photos are captured and then uploaded to Facebook along with a bit of information about the
homeless canine models.
Rat models are experimental and do not show spontaneous compulsive behaviour,
as canine models do.
Many studies have investigated the role of immunity in ALS, and our finding that a gene regulating the immune response is important in
this canine model of ALS could provide a new angle says Emma Ivansson.
Candidate genes and functional noncoding variants identified in
a canine model of obsessive - compulsive disorder.
The canine models are anatomically accurate, with fat, fascia planes, all bones, muscles, ligaments, fully articulating joints, and each of the bodily systems.
It does not fit any human or
canine models.
Treatment of perianal fistulas with human embryonic stem cell - derived mesenchymal cells:
a canine model of human fistualizing Crohn's disease.
Two beautiful seniors are among Roy's
canine models this week.
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Canine models have been identified for a number of inherited retinal degenerations.
The small number of samples used for this analysis highlights the power of
the canine model system for genetic analysis of traits and implies its potential application to identify other important disease loci in dogs.
Rat animal models differ from
our canine model in many important aspects.