Sentences with phrase «cannabinoid agonists»

CB2 cannabinoid agonists such as WIN55,212 - 2 inhibit experimental autoimmune encephalomyelitis (EAE), an animal model of MS, by mediating apoptosis of the encephalitogenic cells that induce brain inflammation (41).

This stands in sharp contrast to exogenous cannabinoid agonists or antagonists that produce indiscriminate and widespread alterations in cannabinoid receptor signaling, often resulting in adverse side effects.

The newly developed CB1 receptor selective antagonist SR141716A was found to reverse cannabinoid agonist (WIN55212 - 2 or CP55940)- induced adenylyl cyclase inhibition.

Not exact matches

This is particularly true in the case of synthetic cannabinoids receptor agonists, known by one of their popular brand names of Spice.

Indeed, our bodies use endo - cannabinoids in much the same way as they use opioids in the central nervous system: as synapse agonists and antagonists.

Following postdoctoral training at the State University of New York, Stony Brook with Masayori Inouye, he joined the Schering - Plough Department of Immunology, where he characterized the biology of a new class of cannabinoid CB2 receptor - specific inverse agonists.

The cannabinoid receptor agonist WIN 55,212 - 2 reduces D2, but not D1, dopamine receptor - mediated alleviation of akinesia in the reserpine - treated rat model of Parkinson's disease

D (2), but not D (1) dopamine receptor agonists potentiate cannabinoid - induced sedation in nonhuman primates

This difference could reflect marijuana's agonist properties at cannabinoid 1 (CB1) receptors, which heteromerize with D2 receptors, antagonizing their effects (43).

Antiobesity efficacy of a novel cannabinoid - 1 receptor inverse agonist, N --LSB-(1S, 2 S)-3 -(4 - chlorophenyl)-2 -(3 - cyanophenyl)-1-methylpropyl]-2-methyl-2 --LSB-[5 -(trifluoromethyl) pyridin -2-yl] oxy] propanamide (MK - 0364), in rodents.

Goya et al. «Recent Advances in Cannabinoid Receptor Agonists and Antagonists», Expert Opinion on Therapeutic Patents, 10 (10): 1529 - 1538, 2000.

The cannabinoid receptor 1 (CB1) is the principal target of the psychoactive constituent of marijuana, the partial agonist Δ9 - tetrahydrocannabinol (Δ9 - THC).

administering to the subject an effective amount of a compound that stimulates bone formation and inhibits bone resorption, wherein said compound is an agonist of a cannabinoid receptor and wherein said subject having a bone disease or condition is a subject having a disease or condition selected from the group consisting of periodontal disease or defect, osteolytic bone disease other than osteoporosis, post-plastic surgery, post-orthopedic implantation, post-dental implantation, age - related osteoporosis, osteoporosis associated with post-menopausal hormone status, primary and secondary hyperparathyroidism, disuse osteoporosis, diabetes - related osteoporosis, osteoporosis associated with depression, osteoporosis associated with hypogonadism and glucocorticoid - related osteoporosis.

Axelrod et al. «Cannabinoid Receptors and Their Endogenous Agonist, Anandamide», Neurochemical Research, 23 (5): 575 - 581, 1998.

Recent studies suggest that cannabinoid receptor - 2 (CB - 2) agonists have anxiolytic and anti-depressant properties [83]; these CB - 2 agonists also limit substance P production [84] and prevent LPS - induced blood — brain barrier permeability [85].