The boosted genes had three main beneficial effects: improving the efficiency of mitochondria, the powerhouse of cells; boosting insulin production, which improves control of blood sugar; and preventing the depletion of telomeres,
caps on chromosomes that help to keep DNA stable and so prevent cells wearing out and ageing.
The boosted genes had three main effects: improving cellular energy efficiency; upping insulin production, which improves control of blood sugar; and preventing the breakdown of
caps on chromosomes that help prevent cells wearing out and ageing.
Longer protective
caps on chromosomes, known as telomeres (yellow), are associated with healthier aging.
Those are the protective
caps on your chromosomes that determine how your cells age.
Not exact matches
Having a baby seems to be linked to shorter
caps on the ends of a woman's
chromosomes — a sign of ageing that has been linked to disease and a shorter lifespan
First a
chromosome is catastrophically shattered when it loses the
caps on its ends, known as telomeres, that hold it together.
Cech was collaborating with the younger professor
on research involving telomeres, the DNA - and - protein
caps that guard
chromosome tips.
They specifically studied the length of telomeres (repeated DNA sequences)
on the ends of
chromosomes in leukocytes (white blood cells); the protective
caps are believed to be markers of biological aging, because they shrink over time.
Growing up in poverty or an unstable home is associated with shortened protective
caps on the ends of children's
chromosomes, researchers report April 7 in the Proceedings of the National Academy of Sciences.
Individuals with one altered gene had longer telomeres, the
caps on the ends of
chromosomes that wear away as we get older, and appeared to be protected against diabetes, the researchers report.
Telomeres can be thought of as «protective
caps»
on chromosomes.
The discovery of telomerase and its role in replenishing the
caps on the ends of the
chromosomes, made by Elizabeth Blackburn and Carol Greider at UC Berkeley and John Szostak at Harvard University in the 1980s, earned them a Nobel Prize in Physiology or Medicine in 2009.
The enzyme lengthens the
caps, or telomeres,
on the ends of
chromosomes, which wear off during each cell division.
«Telomeres, the protein
caps on the ends of human
chromosomes, are markers of aging and overall health,» said Naruhisa Yamaki, M.D., a clinical fellow at the Kobe University Graduate School of Medicine.
A molecular biologist born in Hobart, Australia, Blackburn is best known for her 2009 Nobel Prize — winning discovery of telomeres,
caps on the ends of
chromosomes that protect genetic information from damage and are thought to play an important role in aging and cancer.
The offshore bird's secret, revealed for the first time in May by zoologists at Iowa State University, is in the storm petrel's telomeres, repetitive bits of DNA that sit
on the ends of the
chromosomes in each cell like protective
caps.
Researchers found she had prematurely shortened telomeres, protective
caps on the ends of
chromosomes that reduce with age.
They have detected, for example, revved up signaling molecules involved in inflammation, such as tumor necrosis factor α (TNFα) and other cytokines; skewed populations of natural killer cells and other immune cells; imbalances in the protein - destroying enzymes called proteases; and a shortening of the telomeres, the «end
caps»
on chromosomes, which indicates prematurely aged cells.
Telomeres are
caps on the ends of
chromosomes that shorten as cells replicate — part of the natural aging process.
Blasco is best known for her research
on the enzymes that maintain telomeres — repetitive DNA sequences
capping the
chromosomes — and their role in cancer and aging.
By age 9, their telomeres — the
caps on the ends of
chromosomes that shrink each time cells divide — can be as short as those of someone decades older.
Telomeres — repeating segments of DNA
on the ends of
chromosomes — are often likened to the plastic
caps that prevent shoelaces from fraying.
When researchers took a close look at the cells of Dolly, the cloned sheep, they found that her telomeres, the
caps on the ends of the
chromosomes, were shorter than normal.
Human cells have been rejuvenated by delivering RNA encoding a protein that extends telomeres, protective
caps on the ends of
chromosomes that are associated with ageing and disease.
The study, publishing online January 18 in the American Journal of Epidemiology, found elderly women with less than 40 minutes of moderate - to - vigorous physical activity per day and who remain sedentary for more than 10 hours per day have shorter telomeres — tiny
caps found
on the ends of DNA strands, like the plastic tips of shoelaces, that protect
chromosomes from deterioration and progressively shorten with age.
Horvath says the method is twice as accurate as the next best method of determining tissue age, which is based
on the length of telomeres — the
caps of
chromosomes, which «burn down» with age like candle wicks.
However, it misses some important epigenetic implications, and instead focuses almost entirely
on telomeres,
chromosome caps linked to lifespan.
Telomeres are
chromosome - protecting
caps located
on the ends of DNA strands.
Discovered in 1938 by geneticist Hermann J. Müller, telomeres (Greek for «end part») are essentially protective
caps composed of short DNA sequences
on the tips of
chromosomes.
Both aspects center
on the critical role of telomeres, protective
caps on the ends of
chromosomes that erode with age.
Much like the plastic
caps on our shoelaces that keep them from fraying, telomeres protect our
chromosomes and preserve our genetic information.
POT1 plays a role in protecting the ends of our
chromosomes *, a little like the
caps on the ends of shoelaces that stop them fraying.
«Telomeres, the protein
caps on the ends of human
chromosomes, are markers of aging and overall health,» said study leader Dr. Naruhisa Yamaki, a clinical fellow at the Kobe University Graduate School of Medicine in Japan.
Our
chromosomes have little «
caps»
on them called telomeres, and a short telomere is basically a sign of age.
The answer is via the little protective
caps on the ends of the
chromosomes inside your cells.
Consuming fruits and veggies, and not smoking, has also been associated with longer protective telomeres, the
caps on the tips of our
chromosomes that keep DNA from unraveling.
A: Telomeres are the protective
caps on the ends of each of your
chromosomes, in each of your body's cells.
In addition, elevated sugar levels shorten telomeres, the
caps on the ends of
chromosomes that protect them against unraveling and breakage.
Telomeres — those cute little
caps on the ends of your
chromosomes — are the best marker of your biological age.
New research from a team at Karolinska University suggests that people who stand a lot have longer telomeres -
caps on the end of
chromosomes which protect DNA from wear and tear.
The secret could lie in their telomeres, the tiny
caps on the ends of their
chromosomes — kind of like the plastic wraps at -LSB-...]