One of the most notable additions to the 2017
cars is the T - wing, which has been trialled a Mercedes and a few other teams in testing so far.
My car is a T reg Volvo S40 2.0 l with 130,000 miles.
Live an hour away and half hour before appt another more senior rep called and said
car was no t available.
@ weeks after purchasing
the car we were T - boned by a driver go full speed thru a stop sign without attempting to stop.
Broadside crashes happen when one
car is T - boned by another car.
Not exact matches
That also means Novartis will
be taking on rival Gilead, which
is the only other company to have an approved
CAR -
T therapy on the market (both received the regulatory green light in 2017).
What makes the treatment so fascinating
is its underlying technology, called chimeric antigen receptor
T - cell (
CAR -
T).
There
are still plenty of challenges ahead for Novartis and other companies in the
CAR -
T space.
They
're known as
CAR -
T therapies.
The treatment
is a type of so - called
CAR T - cell therapy — taking a patient's own immune cells, called
T cells, genetically manipulating them to attack specific proteins on cancer, and infusing them back into the patient.
TapouT
was launched as a
T - shirt peddling business out of the trunk of a
car in 1997.
Grasso
is long stock AAPL, BABA,
CAR, EVGN, JCP, MJNA, MON, OSTK, PHM, SQ,
T, TWTR, VRX.
Steve Grasso
is long stock AAPL, BABA,
CAR, EVGN, FB, JCP, MJNA, MON, OSTK, PFE, RAD, SQ,
T, TWTR, VRX.
Those two companies, along with their larger competitor Novartis (nvs),
are developing experimental chimeric antigen receptor
T - cell (
CAR -
T) technology platforms, which
are highly personalized treatments that involve extracting patients» immune cells, re-engineering them to target their specific cancers, and then pumping these sniper - cells back into the body.
As regular readers know,
CAR -
T is one of the most closely watched experimental cancer technologies in the world right now.
With the Kite deal, Gilead
is significantly expanding its footprint in a multi-billion dollar treatment space and will
be one of the first entrants into the new
CAR -
T market if KTE - C19 wins approval in the fall.
The deal will give Gilead access to KTE - C19, which
is a chimeric antigen receptor
T - cell (
CAR -
T) therapy.
Gilead, fresh from its
CAR -
T cancer drug victory last year, has struck a deal with gene - editing specialist Sangamo that could
be worth up to $ 3 billion (with $ 150 million in upfront cash).
Importantly, the deal also means that Gilead / Kite rival Novartis (which had its own
CAR -
T drug approved ahead of Yescarta) and other
CAR -
T companies won'
t be able to get in on Sangamo's platform.
Merck and Bristol - Myers Squibb each have approved immunotherapy drugs, while Gilead Sciences announced Monday it plans to acquire Kite Pharma for $ 11.9 billion, just a few months before the FDA
is expected to approve Kite's
CAR -
T drug for lymphoma on Nov. 29.
CAR -
T cell therapy
is a form of immunotherapy, a rapidly developing cancer treatment that uses patients» own immune cells to attack tumors.
After it
was reported that Rob Ford supporters had asked him to sign «Ford Nation»
t - shirts adorned with the blue Ford Motor company logo at a charity event, the
car manufacturer moved to protect its trademark from unauthorized use.
One of the top contributors to the gain
was bluebird bio, which
is also working on
CAR -
T cell therapy.
Bellicum
is among the flurry of biotechs investing heavily into cell therapies such as experimental chimeric antigen receptor
T - cell (
CAR -
T) treatments for cancer (this
is the next - gen treatment that involves reprogramming immune cells to become cancer killers and has shown promise in blood cancers, which Bellicum specializes in).
Kymriah
is the first
CAR -
T cell therapy to get approved, and several more
are in the works.
CAR -
T's side effects can
be deadly.
Satwani — who hasn'
t delivered the
CAR -
T therapy but
is heading up the program at Columbia, one of the 32 sites Novartis will use — said patients would need to
be monitored closely for about a month, meaning they'd need to
be less than a two - hour drive from their hospital.
SAAB Automobile Australia
is celebrating reduced GST
car prices with Limited Edition extras for the Saab 9 - 3
TS Coupe and
S Sedan to create the best value entry
car in Australia at $ 49,990.
Yescarta
is a so - called chimeric antigen receptor
T - cell (
CAR -
T) treatment.
Kite Pharma, Juno Therapeutics, and Bluebird Bio
are among a growing group of biotech companies working with
CAR -
T.
JCAR015
is among
CAR T - cell candidates covered by Juno's 10 - year, approximately $ 1 billion global collaboration launched in 2015 to develop and commercialize cancer and autoimmune diseases immunotherapies.
The company's
CAR T - cell cancer immunotherapy furthest in development at present
is JCAR017.
However, those statements needed to
be clarified when the investigation
was completed, as no such link
was proven: «[
t] here
is absolutely no evidence so far that terrorists used any bitcoin in financing their actions or why would they not simply use cash if the purpose
is just to rent a getaway
car, mobile phones or anything else they don'
t want tracked.»
'
T is the season for buying a new
car.
Kite
is one of the leading players in the emerging field of
CAR T, and
is competing with rivals Novartis AG, Juno Therapeutics Inc and Bluebird Bio Inc in a race to get the first approved therapy.
Santa Monica, California - based Kite
is developing chimeric antigen receptor
T - cell therapy, known as a
CAR T, which harnesses the body's own immune cells to recognize and attack malignant cells.
The U.S. Food and Drug Administration (FDA)
is expected to decide by Nov. 29 whether to approve Kite's
CAR T, axi - cel, for treatment of adults with advanced lymphoma.
These
CAR -
T cells
were able to penetrate the blood - brain barrier, one of the major hurdles in treating brain tumors.
«Many investors expected a more lengthy FDA review process of the JCAR015 trial (and potentially other
CAR -
T programs) and feared that a higher - degree regulatory scrutiny could increase the development risk of
CAR T cell,» Leerink Research said in a note co-authored by analysts Michael Schmidt, Ph.D., Jonathan Chang, Ph.D., and Varun Kumar, Ph.D. «While it may take several weeks to reopen all clinical sites of the ROCKET trial, we believe the trial shouldn'
t be delayed by more than ~ 3 months.»
Kymriah — the first
CAR -
T ever to get approval —
is now also the first
CAR -
T to get approval for two distinct indications in non-Hodgkin lymphoma (NHL) and B - cell ALL.
JCAR015
is a CD19 - directed chimeric antigen receptor technology (
CAR -
T) product candidate that has
been under study in ROCKET in adult patients with relapsed or refractory B - cell acute lymphoblastic leukemia.
Gilead $ GILD has agreed to buy
CAR -
T pioneer Kite Pharma $ KITE — which
is likely just months away from its first approval — for $ 11.9 billion in cash.
At this time, trials and plans for its other CD19 - directed chimeric antigen receptor (
CAR)
T - cell product candidates, including JCAR017,
are not affected.
After disappointing investors this year with sluggish sales, the prospects for Novartis»
CAR -
T therapy Kymriah may
be improving.
Dr. Newman added that rival
CAR T cell therapy developer Kite Pharma
was still likelier to generate more revenue than Juno with KTE - C19, which last week completed patient enrollment in the Phase II portion of the ZUMA - 1 trial in patients with diffuse large B - cell lymphoma.
«The Model
T set Ford's reputation as a
car company early on, but I
'm here to tell you we made a heck of a lot of Model
T Ford trucks way back then, as well,» Kreipke said.
At EMD Serono, he
was Senior Vice President and Global Senior Scientific Advisor in Immunology and Immuno - Oncology, facilitating major academic center alliances and running the
CAR T - cell program in partnership with Intrexon.
But what if
CAR -
T therapy
is obsolete before it even gets started?
It
is also a potential economic windfall for the companies developing
CAR -
T therapies.
Going back to the Model
T Ford, the
car was essentially a wagon with a gasoline engine.