Sentences with phrase «cardiovascular outcomes»

«There's a growing recognition for the need to screen and treat depression, and that doing so can reduce the risk of negative cardiovascular outcomes,» she says.

They found the drug combination reduces cardiovascular outcomes, increases bleeding and improves survival in stable coronary or peripheral artery disease.

However, few studies have evaluated the relationship between adverse cardiovascular outcomes and marital status in patients with known or suspected coronary artery disease.

Markov model of effect of dark chocolate consumption versus no consumption and its effects on cardiovascular outcomes in a population with metabolic syndrome

«Identifying the factors underlying decreased use of statins in women who should be treated is a first step toward overcoming these barriers and improving cardiovascular outcomes for women.»

The second reason is that Amarin will finally announce the top - line results of its large cardiovascular outcomes trial for Vascepa sometime in the third quarter of 2018.

This is supported by worsened cardiovascular outcomes for diabetics who use primarily insulin for controlling hyperglycemia compared to other therapies.17 Additionally, one study demonstrated that in those with Familial Hypercholesterolemia the difference between those who had had a Myocardial Infarction (heart attack) and those who didn't was that those who did have a heart attack were less insulin sensitive, and had higher insulin levels.18

This press release contains forward - looking statements, including expectations regarding adjudication of MACE events, results and related timing and announcements with respect to Amarin's REDUCE - IT cardiovascular outcomes study; expectations related to the final outcomes of the REDUCE - IT study and the anticipated successful completion of the REDUCE - IT study; and statements regarding the potential and therapeutic benefits of Vascepa.

LEADER 2: baseline calcitonin in 9340 people with type 2 diabetes enrolled in the Liraglutide Effect and Action in Diabetes: Evaluation of cardiovascular outcome Results (LEADER) trial: preliminary observations.

In the study, researchers from Kansas City VA Medical Centre in Kansas City, USA, examined the effect of TRT on cardiovascular outcomes by comparing incidents of heart attack, stroke, and all - cause mortality among different sub-populations of treated and untreated patients.

Raising HDL levels with niacin does not appear to impact cardiovascular outcomes nor does lowering triglyceride levels, Lloyd - Jones points out.

Amarin's clinical development program for Vascepa includes a trial known as the REDUCE - IT cardiovascular outcomes study, an 8,175 - patient study commenced in 2011.

• Diastolic blood pressure levels below 70 mmHg were associated with a higher risk of death, but otherwise they showed no association with cardiovascular outcomes.

Design of the liraglutide effect and action in diabetes: evaluation of cardiovascular outcome results (LEADER) trial.

These results showed that chelation therapy modestly reduced the risk of bad cardiovascular outcomes, but though the study provided a platform for further research, researchers cautioned that the study wasn't conclusive enough to support routine use of the therapy after heart attack.

But Amgen's rivals in the space, Sanofi and Regeneron (which have their own PCSK9 blocking medicine called Praluent), announced that an independent data monitoring committee hasn't seen enough significant evidence in a huge, 18,000 - patient cardiovascular outcomes trial to stop the study early.

«Metabolic syndrome in women may be more closely related to coronary artery disease than other cardiovascular outcomes,» noted Elizabeth Barrett - Connor, MD, corresponding author and Distinguished Professor in the Department of Family Medicine and Public Health at UC San Diego School of Medicine.

REDUCE - IT is the first multinational cardiovascular outcomes study evaluating the effect of prescription pure EPA therapy, or any triglyceride - lowering therapy, as an add - on to statins in patients with high cardiovascular risk who, despite stable statin therapy, have elevated triglyceride levels (150 - 499 mg / dL).

These results support and extend the findings of the PRECISION trial, demonstrating noninferiority for the primary cardiovascular outcomes for moderate doses of celecoxib compared with naproxen or ibuprofen.6 These findings may have the greatest clinical significance in the elderly, who have a high prevalence of arthritis and hypertension.

A previous study by the Intermountain Heart Institute at Intermountain Medical Center found that any level of impaired blood glucose is associated with poorer cardiovascular outcomes.

«Previous studies suggest that reducing heart fat is feasible through weight loss or weight management, but these studies only looked at small numbers of people and there have been no clinical trials linking cardiovascular outcomes with heart fat changes due to weight management interventions.

Recent progress in biochemistry and pathophysiology has enabled search for novel diagnostic markers and therapeutic targets to improve cardiovascular outcomes globally.

«Further analyses will be necessary to replicate these findings, as well as determine whether interventions that focus on patients» level of optimism can have a favorable impact on cardiovascular outcomes,» Fonarow said.

Dr. Gregg Fonarow, a professor of cardiology at the University of California, Los Angeles, said, «There has been great interest as to whether psychological factors, including having a positive outlook and feeling gratitude, can impact cardiovascular outcomes.»

«There is no clear benefit for weight loss, and there's a potential association with increased weight gain, diabetes and other negative cardiovascular outcomes,» lead study author Meghan Azad tells NPR.

«Our data reveal significant issues as well as opportunities for improving cardiovascular outcomes in women — an important objective given the under - treatment and incidence of cardiovascular disease in women,» said co-author Jorge Plutzky, MD, director of BWH Preventive Cardiology and director of the BWH Linda Joy Pollin Women's Heart Center.

According to Dr. Finkielstein, any exercise provides benefit for reducing a person's chance of bad cardiovascular outcomes.

Among type - 2 diabetic patients with an elevated risk of cardiovascular disease — those with high levels of triglycerides and low levels of «good» cholesterol (high - density lipoprotein or HDL)-- fenofibrate cut adverse cardiovascular outcomes by 30 per cent in women and 24 per cent in men.

Another possible explanation is that existing treatments, such as statins, are already so effective at improving cardiovascular outcomes that it has become more difficult to further improve outcomes in high - risk patients.

And heart drugs in general are usually subject to expensive, post-drug approval «cardiovascular outcomes trials» that physicians may use to gauge whether or not to take a chance on a newcomer.

Researchers from Taiwan reveal that antiviral therapy for hepatitis C virus (HCV) improves kidney and cardiovascular outcomes for patients with diabetes.

Low carb plant based diets may be dangerous: «The associations of low carbohydrate, high protein, and low carbohydrate - high protein scores with cardiovascular outcomes were not, in general, statistically significantly different between women whose protein intake was mainly of animal origin and those whose protein intake was mainly of plant origin.»

However, a recent clinical trial (39) did not find any beneficial effects of short - term (6 wk) dark chocolate and cocoa consumption on cardiovascular outcomes or on neuropsychological tests.

Two other multi-national trials randomized 27,438 patients to either bococizumab or placebo and were designed to evaluate the impact of the drug on cardiovascular outcomes, including nonfatal heart attack and stroke, hospitalization for unstable angina requiring urgent revascularization, or cardiovascular death.

The study, «Lipid lowering and mortality and cardiovascular outcomes,» was published in the April 3, 2018, issue of JAMA.

The paper stresses that more research, especially randomized controlled trials with long - term follow - up, would be needed to reach a definite conclusion on the risk of TRT on cardiovascular outcomes.

«Although evidence of benefits with vitamin D supplementation in cardiovascular outcomes are still lacking, strategies to raise endogenous vitamin D should probably be advised in the prevention of cardiovascular disease.»

Among women with diabetes, increased risk was statistically significant for all cardiovascular outcomes measured and across all sizes of particulate matter.

The researchers examined associations between different antidepressant drugs and rates of three cardiovascular outcomes in people with depression.

The Women's Health Initiative Study in 2003 examined the effect of HRT on healthy postmenopausal women with a particular interest in cardiovascular outcomes.

«Furthermore, the findings are the first to report on a large UK population and identify an at - risk group of relatively young women ideally suited for targeting risk factor management to improve long term metabolic and cardiovascular outcomes.»

«Intuitively, many had thought that men with «poor» nutritional status at baseline may benefit more from long - term multivitamin use on cardiovascular outcomes; however, we did not see any evidence for this in our recent analysis,» said corresponding author Howard Sesso, ScD, MPH, of the Division of Preventive Medicine and the Division of Aging at BWH.

«Our findings suggest that we need to be concerned about weight fluctuation in this group that is already at high risk due to coronary disease,» says lead study author Sripal Bangalore, MD, director of the cardiovascular outcomes group in the Cardiovascular Clinical Research Center at NYU Langone.

However, telomere length and CPC levels are independent and additive predictors of adverse cardiovascular outcomes (such as death, heart attack, stroke, or hospitalization for heart failure), he finds.