We are inadvertently enriching this water with bacteria that
carry resistance genes and then exposing people to these bacteria because the water is used to irrigate urban parks.»
If these bacteria happen to come into contact with other microbes that
carry resistance genes, those genes can pop over in one step.
«But some of these bacteria
carry resistance genes that are known to cause problems in the clinic.
Although the sprayed fields had fewer larvae overall, those survivors were more likely to
carry resistance genes, presumably because the double - whammy of Bt crops in neighboring rows and the added Bt spray increased the selection pressure on the insects.
Potatoes engineered to
carry a resistance gene withstand late blight (left); normal potatoes shrivel when exposed to the pathogen (center).
Perhaps most alarming to some scientists is that 21 % of the lab moths
carried the resistance gene — a rate 10 times higher than that seen in any other bug.
In one case, the CDC network helped diagnose bacteria
carrying resistance genes in an Iowa nursing home resident with a urinary tract infection.
Not exact matches
And on the subject of public health, it is worth exploding the number one myth of anti-GM lobbyists that the antibiotic
resistance genes carried by some GM crops might lead to devastating human epidemics if transferred to bacteria.
While Wright was not surprised that the bug would
carry such
genes as antidotes to its own weaponry, he was startled to see that the antidote
genes were nearly identical to the
resistance genes in vancomycin - resistant enterococcus (VRE), the scourge of American and European hospitals.
Of the Iron Age individuals, three
carry at least one Duffy null allele, protecting against malaria, and two have at least one sleeping - sickness -
resistance variant in the APOL1
gene.
If a bacterium
carries several
resistance genes, it is called multiresistant or, informally, a superbug.
More than three fourths of all current antibiotics used to treat human infections are produced by Actinobacteria, which at the same time
carry antibiotic
resistance genes.
But by investigating the DNA sequence around the
resistance genes, the team figured out how the
resistance genes transfer occurred through a new mechanism named «
carry back,» where the pathogen basically has a primitive form of «sex» with the Actinobacterium and takes up its
resistance genes after it dies.
The former target, say, using
gene editing techniques to inactivate HIV receptors and achieve
resistance of blood cells to the virus (which Sangamo BioSciences is working on in clincial trials) is different than helping parents who both
carry genes for Huntington's Disease to have a child that is free of the disease (a change to the genome that would be passed on to future generations and would likely not be very commonly needed).
«Soybean genotypes
carrying Rpp1b, Rpp2, Rpp3, and Rpp5a
resistance genes, and cultivars Hyuuga and UG5 (
carrying more than one
resistance gene), were observed to be resistant against most of the African rust strains, and therefore may be useful for soybean - breeding programs in Africa and elsewhere,» Hartman says.
The introduction of penicillin in the 1940s led to the selection of S. aureus strains that
carried the methicillin
resistance gene.
They found that the phages from antibiotic - treated mice
carried significantly higher numbers of bacterial drug -
resistance genes than they would have
carried by chance.
That's because gut phage from mice treated with one drug
carried high levels of
genes that confer
resistance to different drugs, which means that the phage could serve as backup when bacteria must find ways to withstand a variety of antibiotics.
The
genes encoding NDM - 1 and other antibiotic
resistance factors are usually
carried on plasmids — circular strands of DNA separate from the bacterial genome — making it easier for them to spread through populations.
Using a
gene - editing system that can disable any target
gene, they have shown that they can selectively kill bacteria
carrying harmful
genes that confer antibiotic
resistance or cause disease.
These crops, being embraced by big agriculture in the U.S.,
carry genes that imbue them with
resistance to herbicides and lace their tissues with a bacterial toxin harmless to humans but fatal to pests that may try to feed on them.
The permits enabled a group at Huazhong Agricultural University in Wuhan to produce two varieties of rice
carrying a
gene from the Bacillus thuringiensis (Bt) bacteria that provides pest
resistance.
Next, researchers isolated the candidate
gene and used biotechnical approaches to develop transgenic plants that
carried the Sr35
gene and showed
resistance to the Ug99 race of stem rust.
The genetically manipulated agrobacteria,
carrying the
gene for PAT, were then used to infect the crop in which
resistance was required.
Last summer, agribusiness giant Syngenta, based in Basel, Switzerland, conducted the first field trials of maize (corn) containing engineered mini-chromosomes, and showed that the mini-chromosomes, which
carried multiple
genes for insect and herbicide
resistance, were stable in the field.
Liu's team however have identified MCR - 1, a
resistance gene that is
carried on a plasmid — a swappable circle of DNA that can be easily passed between bacteria.
Then the team let loose a special strain of diamondback moth pupa, some of which
carried at least one copy of a
resistance gene to the Bt toxin.
When insects from such a species
carry two copies of a
resistance gene, they can survive high doses of Bt.
Into some bacteria they inserted
genes for
resistance to particular antibiotics; the idea is that only the antibiotic - resistant bacteria are
carrying the real message.
But ominously, all the bacteria also
carried genes conferring
resistance to many other antibiotics, including penicillin and cephalosporins.
«For all of the bacteria we tested, their conjugation rate is sufficiently fast that, even if you don't use antibiotics, the
resistance can be maintained — even if the
genes carry a high cost.»
At present, the researchers have permission to test the TILs
carrying the
gene for neomycin
resistance on 10 patients suffering from melanoma, a type of skin cancer.
A plasmid in the E. coli
carried the
gene for extended spectrum cephalosporin
resistance, as well as four other
resistance genes.
The
gene for
resistance to extended spectrum cephalosporins is frequently
carried on plasmids, often along with multiple
genes for
resistance to other antimicrobials.
Dr Melita Gordon, from the University of Liverpool's Institute of Infection and Global Health, said: «Importantly, the antibiotic
resistance genes, which have previously been
carried on a separate genetic package, have now been incorporated into the main chromosome of the bacteria itself, which is likely to make it easier for the Typhoid strain to retain these
resistance genes.»
Plasmids are pieces of independent DNA that often
carry multiple antibiotic
resistance genes.
use CRISPR - Cas technology to
carry out genome - wide screens of
gene -
gene,
gene - drug and cancer - microenvironment interactions in cells and mice in order to explore fundamental biology and to identify drug targets and drug
resistance / sensitisation mechanisms.
In pathogenic bacteria, plasmids may
carry antibiotic
resistance genes.
The widespread use of antibiotics puts selective pressure on only the hardiest bacteria to survive — which often
carry virulence or drug
resistance genes.
Our gut already contains billions of bacteria
carrying resistances to kanamycin and ampicillin, the two most commonly used antibiotic marker
genes in GM crops.
Mobile DNA can
carry genes for virulence and drug
resistance, as well as benign
genes.
Most antibiotic
resistance probably comes from soil bacteria, and the
genes they
carry genes can readily be disseminated from one species of bacteria to another on plasmids.
Bacteria will frequently contain small chromosomes called plasmids that commonly
carry genes for antibiotic
resistance.
The researchers were able to predict the direction of this effect with high accuracy, based on the sequences of bacteria present and the
resistance genes they
carried in samples taken before treatment.
People who
carry a particular type of
gene have natural
resistance against typhoid fever according to new research published in Nature Genetics.
Epidemiological evidence has always suggested that
resistance arose around this period, when the mecA
gene encoding methicillin
resistance carried on an SCCmec element, was horizontally transferred to an intrinsically sensitive strain of S. aureus.
Several MGEs showed variable distribution across the CC22 phylogeny, including two antimicrobial
resistance plasmids (pWBG751 - like and SAP078A - like,
carrying erythromycin and heavy metal
resistance genes, respectively), a pathogenicity island
carrying the enterotoxin C
gene and two phage types Sa1int and Sa6int.
Background: Horizontal transfer of mobile genetic elements (MGEs) that
carry virulence and antimicrobial
resistance genes mediates the evolution of methicillin - resistant Staphylococcus aureus, and the emergence of new MRSA clones.
We postulated that plasmids
carrying carbapenemase
genes were exchanged between bacterial hosts in sewage, and used short - read (Illumina) and long - read (MinION) technologies to characterize plasmids encoding
resistance to antimicrobials and heavy metals.
Antimicrobial
resistance genes can be
carried on plasmids or on mobile elements integrated into the chromosome.