But some people thought that bacteria
carrying tumor genes would be dangerous for humans.
Not exact matches
Indeed, all of the
tumors from patients who
carried this particular T - to - A mutation also had additional mutations that inactivate the APC
gene.
Vassaux's team next plans to test
gene therapy
carried by nanoparticles on a variety of
tumors in animals.
But the diagnostic test, which checks to see if a patient's
tumor carries a mutation in a
gene coding for anaplastic lymphoma kinase, called ALK, is just $ 250.
They found that carcinoma cells from smokers
carried the «transcriptional fingerprint» (i.e. the pattern of
genes that were switched on or off) of basal cells, suggesting that the
tumors may originate from this type of cell.
Polyploid cells, which
carry additional copies of important
tumor suppressor
genes, are better protected and more resistant to cancer formation because they have these extra copies of the genome,» said Dr. Zhu, who is also an Assistant Professor of Pediatrics and Internal Medicine at UT Southwestern.
Injections of iPSC - EPCs did not however have significant effect on
tumor growth or on overall survival, but transducing cells with a baculovirus expressing CD40L, a member of the TNF
gene family which can induce apoptosis [6, 7], and injection into the breast cancer lung metastasis, increased levels of pro-apoptotic cytokines in lung tissues, indicating the induction of apoptosis by CD40L
carried by the EPCs (See figure).
A subset of ALCL
tumors carries chromosomal aberrations involving the anaplastic lymphoma kinase (alk)
gene on chromosome 2p23 resulting in ALK overexpression (2).
Patients with FOP
carry the ACVR1 mutation in every cell, while the
gene is mutated only in the
tumor cells of DIPG patients.
Faulty
tumor suppressor
genes, on the other hand, fail to
carry out these functions and give rise to faulty cells that can grow uncontrollably and cause cancer.
These kind of mice are an extraordinary resource for modeling human disease; for instance, research has found that mice that are genetically mutated to
carry the BRCA1
gene (a human breast cancer
gene) behave more similarly to human cancer patients than those mice who have had a
tumor physically transplanted in.