To the scientists, these findings collectively suggest that changes in chromatin leads to
cascades of gene activity that drive fly development.
Not exact matches
Scientists have shown that this voltage change can trigger a
cascade of biochemical reactions that relay messages to the cell nucleus, changing
gene activity and altering cell growth and differentiation.
This
cascade of activity enables PRC2 to spread this modification over the entire neighboring
gene loci, thereby marking it for silencing.
Using a variety
of experimental techniques, the researchers determined that the
gene fusion initiates a
cascade of events that increases mitochondrial
activity.
McKay and his team plan further research to study how these
cascades of changing chromatin accessibility and
gene activity differ from one part
of the fly to another.
Using the fruit fly Drosophila, a standard lab model for studying animal biology, the researchers discovered a
cascade of molecular signals that program
gene activity to drive the fly from one stage
of maturation to the next, like a baby turning into an adult.