Sentences with word «catenin»

Using a zebrafish model, researchers were able to reverse the defects caused by the UBQLN4 gene variant by inhibiting the beta catenin signaling pathway with the drug quercetin.

Methods: Rat neonates and AEC II from premature rats were exposed to hyperoxia in the absence or presence of CGRP, Wnt7b and β - catenin protein levels were measured by Western blot analysis, while T cell factor (TCF) and c - myc mRNA levels were determined by reverse transcription - polymerase chain reaction (RT - PCR).

On the inside of the cell, E-cadherin binds to linker proteins known as catenins, which attach to a structural scaffold that lies adjacent to the adhesion site, the actin cytoskeleton.

But CCL4 expression is suppressed by tumor cells with high beta - catenin levels.»

Phenotypic characterizations reveal high levels of CD44, α2β1 integrin, and β - catenin expression in holoclones, whereas meroclones and paraclones show markedly reduced expression of these stem cell markers.

They show how beta - catenin prevents T cell invasion and undermines treatment.

See: Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity

Birgit Kagermeier - Schenk (Weidinger, TUD)-- «Genome - wide analysis of Wnt / beta - catenin target genes in zebrafish embryogenesis and characterization of a novel modifier of Wnt signaling pathways» (2010)

W. E. Reintsch, A. Habring - Mueller, R. W. Wang, A. Schohl, F. Fagotto, beta - Catenin controls cell sorting at the notochord - somite boundary independently of cadherin - mediated adhesion.

Our main goal is to identify small molecules that specifically block the beta - catenin mediated transcription, which essential for tumor development.

Bulk - cultured PC3 - GFP cells (A), holoclone P1H8 (B)-- , or meroclone P2H3 (C)-- derived cells were plated on glass coverslips and stained for CD44, α2β1, and / or β - catenin using monoclonal antibodies.

Colleagues of Ben - Ze «ev had examined the effect of turning off b - catenin on other, unrelated functions within cells.

In addition to its structural role in epithelial junctions, beta - catenin activates TCF -4-mediated transcription of genes required for cell proliferation.

Inhibition of the gene beta - catenin causes worms to regenerate a head instead of a tail (right head).

Apart from involvement in DNA repair, TRF2, has been reported to interact with β - catenin which is a transcription factor and also a developmental gene [12].

Targeting of Wnt / β - Catenin by Anthelmintic Drug Pyrvinium Enhances Sensitivity of Ovarian Cancer Cells to Chemotherapy.

The findings, reported in the July issue of Genes, Chromosomes and Cancer, suggest that activation of MYC, STAT3, and beta - catenin transcription networks could be an early molecular step in gastric tumorigenesis.

Blocking Wingless / beta - catenin also inhibits the MGMT enzyme, which in turn prevents cytostatic resistance.

Tucci V., Kleefstra T, Hardy A, Heise I, Maggi S, McGuffin L, Vizor L, Dodero L, Tsaftaris S, Romero R, Nillesen n, Peart - Vissers L, Kempers M, Silfhout A, Iqbal Z, Orlando M, Maccione A, Lassi g, Farisello P, Constestabile A, Tinarelli F, Nieus T, Raimondi A, Greco B, Cantatore B, Gasparini L, Berdondini L, Bifone A, Gozzi A, Wells S, Nolan P Dominant β - catenin mutations cause intellectual disability with recognizable syndromic feature (2014) Journal of Clinical investigation 5.

Strikingly, we observed that induction of either ß - catenin LOF or GOF mutations in MuSCs leads to the impairment of skeletal muscle regeneration following injury.

Four genes, all with synaptic function, have the most case - only variation: neuronal cadherin (CDH2), catenin alpha2 (CTNNA2), ataxin - 1 (ATXN1), and plasma glutamate carboxypeptidase (PGCP).

Cytoplasmic NOTCH and membrane derived β - catenin link fate choice to epithelial - mesenchymal transition during myogenesis

When they blocked expression of the new protein with small interfering RNA, a chemical cousin of DNA, Listeria could not enter the cell, and epithelial cells did not recruit α - catenin at their junctions.

Interestingly, treatment with a selective and potent small - molecule inhibitor of Setd7 activity (PFI - 2)[4] impaired - catenin translocation and myogenic gene expression, and thereby promoted the maintenance of MuSCs in an immature state.

«Tumor cells without beta - catenin produce an immune - signaling molecule known as CCL4, which attracts CD103 + dendritic cells.

The FDA - approved antihelminthic drug, pyrvinium pamoate (PPAM), was found in a screening for compounds that promoted β - catenin turnover and, thereby, inhibiting Wnt signaling in ovarian and other cancer cells (Table 1)[51, 56].

Tumors with beta - catenin did not.

«We noticed that tumors with elevated beta - catenin lacked a subset of dendritic cells known as CD103 +,» said co-author Stefani Spranger, PhD, post-doctoral fellow in the University of Chicago's Department of Pathology.

They found that tumors that lacked beta - catenin responded to treatment.

They also stabilize beta - catenin through physically interacting with the protein.

In APC - deficient colon carcinoma cells, we demonstrated that ß - catenin accumulates and is constitutively complexed with the TCF family member TCF4, providing a molecular explanation for the initiation of colon cancer (5).

Simplet / Fam53b is required for Wnt signal transduction by regulating β - catenin nuclear localization.

Moreover, inhibition of the canonical WNT signaling pathway using the siRNA against β - catenin reduced the expression of miR - 150 in the miR -142-expressing MDA - MB - 231 cells (Figure 5D).

(B) E8.5 embryos hybridized with a β - catenin probe to mark the patterning field and feather primordia.

(D) Decrease of the miR - 150 transcription by β - catenin knockdown.

8) The β - catenin staining presented in Figure 7 is not convincing.