This cell death is induced by many rough attenuated Brucella strains, including Brucella
cattle vaccine strain RB51, B. abortus wboA mutant VTRA1, and B. suis wboA mutant VTRS1.This cell death is prevented by wild type virulent Brucella in infected macrophages, but not in dendritic cells.
Already, the Pirbright team has used the new
vaccine to give a sample of British
cattle complete immunity to lethal
strains of LSD and rinderpest.