The causal mechanisms of this disease remain elusive.
Not exact matches
Researchers at the Boyce Thompson Institute (BTI) and Virginia Tech have discovered a new
mechanism in the continual arms race between plants and pathogenic bacteria, which tomatoes use to detect the
causal agent
of bacterial speck
disease.
Intersection
of immunogenomic resources with
disease associated variants paints a detailed picture
of disease causal mechanisms.
The results
of this study suggest that high - resolution fine - mapping in large samples can convert many discoveries from genome - wide association studies into statistically convincing
causal variants, providing a powerful substrate for experimental elucidation
of disease mechanisms.
However, since most
of the
disease variants fall outside the gene coding sequences, thereby implicating gene expression regulation as the
causal mechanism, the functional interpretation
of the exact role
of the associated variants remains to be determined.
However, the recommendation to eat fruit and vegetables to prevent chronic
diseases is mainly based on observational epidemiological studies, which leaves much uncertainty regarding the
causal mechanism of this association.
• explore multiple biological responses to chronic stress (e.g. elevated inflammation, accelerated atherosclerosis, and increased insulin resistance) to elucidate
causal mechanisms of adult
diseases that are associated with adverse childhood experiences.