Sentences with phrase «cause aberrant»

A hallmark of the Notch pathway is its gene dosage sensitivity, such that small differences in the amount of Notch activity can cause aberrant cell fate choices and T - cell leukemia.

Defective BRCA1 causes aberrant expression of non-coding satellite RNA that leads to genomic instability, thereby promoting cancer development.

Correctly diagnosed «classic» fibromyalgia is a problem arising from deep in the nervous system and brain that causes aberrant pain perception.

On their own, they enter the central nervous system in abnormally high concentrations, causing aberrant neuronal firing and potential cell death.

But «indiscriminate breeding causes aberrant qualities to rise to the surface.»

In rare cases, the tumor may affect brain functioning, causing aberrant behavior and personality changes.

Not exact matches

Several factors newly discovered to be phosphorylated by GSK - 3 are also known to be mutated in acute myeloid leukemia, a condition in which aberrant splicing causes uncontrolled white blood cell proliferation.

«Understanding the mechanisms that promote aberrant neurogenesis caused by traumatic brain injury and subsequent seizures may open new therapeutic avenues to prevent epilepsy and associated memory problems caused by impact,» said senior author Dr. Jenny Hsieh, Associate Professor of Molecular Biology and a member of the UT Southwestern Hamon Center for Regenerative Science and Medicine.

The aberrant and ongoing activation of ERVs caused an accumulation of retroviral proteins in the affected cells and deregulation of genes and pathways.

The experiments reveal that the sudden loss of energy supply to the heart cells and the subsequent rapid «reboot» during treatment causes mitochondria to falter and trigger a whirlwind of aberrant electrical signals.

The current approach provides a novel and unique, non-invasive strategy that aims to modulate and correct the aberrant neural pathways that cause tinnitus.

In asthma this aberrant immune response leads to immune cells infiltrating the lungs, where they cause inflammation that affects lung function and leads to difficulties in breathing.

EPFL scientists have found that chronic inflammation can cause regenerating cells to grow into new, aberrant types; this is called metaplasia, and is a disorder linked to prolonged inflammation.

Preconception zinc deficiency also caused approximately half of embryos to exhibit delayed or aberrant development.

«I believe we'll come to know that many diseases are caused by aberrant splicing,» he adds.

Dr. Shelanski and his team hypothesized that aberrant activation of caspase - 2 may cause synaptic changes in Alzheimer's disease.

With these tools, Verma is revealing how the aberrant expression of normal cellular genes can causes tumors.

Genetic Reduction of Vascular Endothelial Growth Factor Receptor 2 Rescues Aberrant Angiogenesis Caused by Epsin Deficiency.

Scientists investigating the mechanisms of Down Syndrome (DS) have revealed the earliest developmental changes in embryonic stem cells caused by an extra copy of human chromosome 21 — the aberrant inheritance of which results in the condition.

Mirror Movement - Like Defects in Startle Behavior of Zebrafish dcc Mutants Are Caused by Aberrant Midline Guidance of Identified Descending Hindbrain Neurons.

Errors in chromosome segregation are a major cause for birth defects and embryonic lethality in humans, and the most common genetic alteration in human tumors is aberrant chromosome numbers, called aneuploidy.

Publication: Loss of NF - κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT -1-Dependent Manner.

The results of her project will help scientists develop novel therapies to target the regulatory proteins that cause CD47 overproduction in leukemia and other cancer stem cells, with the goal of restoring immunosurveillance and enabling the immune system to recognize and destroy these aberrant cancer cells.

Aberrant imprinting is the major cause of embryo lethality of parthenogenic embryos.

It is a genetic disease caused when a child carries two copies of an aberrant gene — one copy from each parent.

279/5: 30 Vibration - induced urticaria due to aberrant mast cell degranulation caused by a mutation in ADGRE2.

This study shows for the first time proteins interacting with Nbeal2 and points to the dysregulation of the canonical signaling pathway of Dock7 as a possible cause of the aberrant formation of platelets in GPS cases and Nbeal2 deficient mice.

She also had to worry that any telomerase activity she saw was an aberrant result caused by one of the DNA polymerases that replicate the middle of the chromosomes.

Bottomline: aberrant insulin signaling that inhibits autophagy, particularly mitophagy, is the first cause of death.

A customized dietary protocol, targeted supplementation, and mind - body therapies enabled my dramatic recovery, as did addressing root causes of dysfunction, including micronutrient deficiencies, heavy metal toxicity, hypothalamic - pituitary - adrenal axis dysfunction, sex hormone imbalances, dysbiosis, stealth infections, blood sugar dysregulation, and aberrant mitochondrial function.

Moreover, the autoimmune protocol addresses many of the underlying root causes of aberrant immune responses.

Even though aberrant cilia in contact with the corneal surface are assumed to cause corneal irritation, distichiasis in the dog may be clinically insignificant in some individuals [8, 19].

The main causes are herpetic infection of the eye, injured cornea with aberrant healing, low tear production (usually associated with herpes), poor tear quality, inability to completely or normally close the eyelids over the eye, insufficient frequency of blinking, or entropion (inward rolling of the eyelid, commonly due to herpesviral infections).

In my experience, especially in medium - large breed dogs, the more common scenario is a low grade inflammation of the eyes causing increased tear production (or other aberrant discharge).

Uncommonly, aberrant responses of the immune system to medications, or unknown factors also causes arthritis in multiple joints at the same time.

For example certain toxic elements such as lead, certain metabolic malfunctions such as liver disease, certain aberrant migration of a parasitic disease such as roundworm, and certain tumors are all possible causes of encephalitis in addition to the infectious causes such as Lyme disease.

Meningoencephalitis in two stranded California sea lions (Zalophus californianus) caused by aberrant trematode migration.

Recent intrusions of cold arctic air into the continents may be caused by aberrant behavior of the polar vortex.

Latin name: Quercus alba Oak is a major genus used to build log structures in the eastern U.S. Sometimes, however, we find that the individual trees experienced some major disturbances that caused very aberrant rings, making crossdating all but impossible.