Sentences with phrase «cause additional mutations»

Not exact matches

In experiments on cell cultures, both of these inhibitors succeeded in breaking various forms of the TKI resistance: including forms caused by additional mutations of the gene Bcr - Abl as well as those caused by large quantities of the protein Gab2.

Eight additional affected children in six unrelated families were found to also have disease - causing mutations in this gene.

The researchers considered two possible explanations: Disease suppression might be the result of one or two additional substitutions on the same gene that buffer the harmful effect of the mutation; or suppression may be caused by numerous small substitutions throughout the genome that form an aggregate «shield.»

«Smoking can cause new mutations among cancer survivors that can lead to secondary and additional primary cancers.

Velculescu cautions that medical practice may not change much until additional studies validate their findings, and there are ongoing clinical trials studying the removal of fallopian tubes instead of ovaries in women with cancer - causing, hereditary BRCA1 and BRCA2 mutations.

Geneticist Richard Sturm of the University of Queensland in Brisbane, Australia, an author of one of the papers says that someday scientists may find additional mutations that cause blue eyes but for now, the signs point to a single change.

In some patients, the cancer cells carrying the T790 - M mutation acquired an additional EGFR mutation not seen before, labeled C797S, which blocked the AZD9291 from docking to the tumor cells, and causing the disease to advance.

Additional experiments with cultured cells suggested that the mutation interferes with one of the enzymes that breaks down the APP protein and causes a 40 % reduction in β amyloid formation, Stefansson and colleagues report online today in Nature.

[69,72] In gastrointestinal stromal tumors (GIST), secondary resistance to KIT inhibition is caused primarily by development of additional KIT mutations.

Thus the search is on is to discover additional cancer - causing genes «downstream» of TET mutations that drive uncontrolled cell division in either context.

Additional in vitro and in vivo studies are needed to determine the cause of the specificity of JAK2V617F for myeloid diseases, as second mutations, host modifiers, differential cytokine receptor expression, and other factors may influence the ultimate phenotype of hematopoietic progenitors that acquire the JAK2V617F mutation.

When done improperly, the process can cause you to breathe in additional, possibly large doses of mercury vapor — a big problem if you have the MTHFR gene mutation and intestinal permeability (an excess of mercury exposure all at once can overburden your detox pathways).

That caution was subsequently validated by additional research that completely excluded the Phosducin gene and led to identification of gene and mutation causing Type A PRA.