Sentences with phrase «cause alterations»

To determine whether defects in the mitochondrial dynamics of this small nucleus of POMC neurons could cause alterations in metabolism, researchers removed a mitochondrial dynamics protein, Mitofusin 1, from these cells in mice.

One of the reasons for this is the lack of knowledge on the cellular mechanisms which cause alterations in nerve transmissions and the loss of memory in the initial stages of the disease.

The research was carried out in mice, but it is hoped that the breakthrough will pave the way for safe cannabis - based therapies that do not cause alterations in mood, perception or memory.

McLean Hospital neuroscientists have found that immune system activation during pregnancy and right at birth can cause alterations in the brain's neural circuits during young adulthood that are consistent with behavioral symptoms common in autism spectrum disorder (ASD) and other developmental conditions.

Physical punishment is associated with a range of mental health problems in children, youth and adults, including depression, unhappiness, anxiety, feelings of hopelessness, use of drugs and alcohol, and general psychological maladjustment.26 — 29 These relationships may be mediated by disruptions in parent — child attachment resulting from pain inflicted by a caregiver, 30,31 by increased levels of cortisol32 or by chemical disruption of the brain's mechanism for regulating stress.33 Researchers are also finding that physical punishment is linked to slower cognitive development and adversely affects academic achievement.34 These findings come from large longitudinal studies that control for a wide range of potential confounders.35 Intriguing results are now emerging from neuroimaging studies, which suggest that physical punishment may reduce the volume of the brain's grey matter in areas associated with performance on the Wechsler Adult Intelligence Scale, third edition (WAIS - III).36 In addition, physical punishment can cause alterations in the dopaminergic regions associated with vulnerability to the abuse of drugs and alcohol.37

As the consequence, the irritation causes alterations in the baby's sucking pattern which, in its turn, causes pains for mothers.

They also found that the disruption of the connectivity of these cells during brain development causes alterations in brain oscillatory activity and disturbs the function of place cells, a type of pyramidal neuron that becomes active when an animal is located in a particular place in its environment.

The virulence effects of H pylori have been shown to derive from bacterium factors causing alterations in gastric epithelial cells.

Expression of mutant Ets protein at the neuromuscular synapse causes alterations in morphology and gene expression

The drugs, azacitidine (AZA) and decitabine (DAC), are epigenetic - targeted drugs and work to correct cancer - causing alterations that modify DNA.

They cause an alteration in gene expression, leading to a suppression of key mitochondrial enzymes, like carnitine palmitoyltransferase — which finally solves the mystery of why those eating vegetarian have a 60 % higher expression of that fat - burning enzyme.

The over-consumption of industrialized processed foods, which contain questionable ingredients such as High Fructose Corn Syrup and processed vegetable oils, can cause alteration of gut microbiota, gut infection, and inflammation.

As mentioned, the regular consumption of a high - fat diet causes alterations in the characteristics of the intestinal microbiota, yet when antimicrobials are administered along with the Western - style diet, the detrimental diet - induced effects on systemic inflammation, systemic LPS burden and glucose - insulin dysregulation are minimized [21].

Zinc deficiency causes alterations in immune response that probably contribute to increased susceptibility to infections, such as those that cause diarrhea, especially in children [49].

«The study showed that genistein caused alterations to the ovaries during early development, which is partly responsible for the reproductive problems found in adult mice.»

The first observation we made was that by adding the branched chain amino acids, the fat - to - protein ratio of the diet changed from 4:1 to around 2.5:1 (depending on the patient's weight) without causing any alteration in ketosis.

However, we suspect the current Nexus 10 is about to be replaced by Google, so this may cause some alteration in the price and specifications.

Physical activity, or the lack of it, causes alterations in a number of physiological parameters.

Changes in gait may be caused by muscular pain which may cause an alteration in the placing of the paws whilst walking; it would be best to rest Gizmo for a few days, place in a cat carrier if you need to so that movement is restricted.

Unhealthy Environments Can Cause Cellular Alteration One of the most interesting findings was that these environmental factors are causing an alteration in biochemical pathways at cellular and subcellular levels — and that these physical alterations can lead to Alzheimer's and Parkinson's, as well as diabetes, obesity, and cardiovascular disease.

Variations in HR occur due to the constant need of the heart to adapt to changing circumstances, and it is thought that loss of balance of the sympathetic and parasympathetic nervous systems causes an alteration to the structure of HRV.5 6 HRV, as a measure of nervous system balance, can therefore provide a quantification of physiological changes associated with mental health disorders, with many studies investigating these associations through a number of time domain, frequency domain and non-linear methods of quantifying HRV.7 — 9

Not exact matches

That very process of scrutiny and commendation will likely change previous understandings and attitudes, and will most likely produce commensurate alterations in their faith traditions: conversion causes not just numerical change but mental shifts as well.

There is no doubt that the Second Vatican Council, its proceedings and debates, the differences of opinion that became apparent, the press reports that retailed and exaggerated them, the existence of tendencies and parties thus reveals, the struggle for decisions this way and that the alterations in liturgy and law decided upon — all these experiences caused profound astonishment, disquiet and consternation in many Catholic circles, even to a considerable extent among the clergy.

The disciples» ascent of the mountain, for example, recalls the difficulty of any personal journey, while the change in the appearance of Jesus is a stark reminder of the physical alterations caused by chemotherapy treatments.

Water is a liquid that may or may not cause cancer, bowel disease, and DNA alterations in mice.

«Sucralose is an artificial sweetener that may or may not cause cancer, bowel disease, and DNA alterations in mice.»

By doing so they inhibit the production of «poisonous» waste products that cause chronic morbid alterations in the system, especially arteriosclerosis.

It seems the alterations caused by human selective breeding has caused gluten to become significantly more problematic for people.

Not surprisingly, this alteration caused the ROI to spike at every data point.

The only thing that can happen is the coaching staff, if it is top notch, can evaluate what causes the matchup problem and instill a program or alteration of play style to try to stop it.

Along with the findings that the main cause was a lack of police control, and that there had been significant alteration of statements and other attempts by the police to pass the blame on to the fans, was the conclusion that in 41 cases «what happened... after 3.15 pm was significant in determining the outcome.»

Even a lovely pregnancy glow can't compensate for weight gain, swollen feet, acne, and the host of physical alterations caused by carrying a child.

Team physicians, athletic trainers, and other personnel responsible for the medical care of athletes face no more challenging problem than the recognition, evaluation and management of concussions (generally defined as injury to the brain caused by a sudden acceleration or deceleration of the head that results in any immediate, but temporary, alteration in brain functions, such as loss of consciousness, blurred vision, dizziness, amnesia or loss of memory).

The alterations to the brain, thanks to being a mom, cause hardship when it comes to juggling multi-tasking.

There are also concerns that the frequency of the sound waves that bombard baby might cause distress, or just be create unique alterations to baby's development.

Sweeping alterations to the electoral map of Britain caused by the coalition's decision to cut the number of MPs from 650 to 600 must be approved by October 2013 at the latest if they are to take effect at the planned 2015 general election.

It might be possible then to link the alterations to environmental changes such as stressful events or diet, which have been shown to cause inheritable epigenetic changes in mice.

For instance, alterations to these chemical switches can change the architecture of the heterochromatin, causing genes to be expressed or silenced.

«More broadly, it suggests that accumulated alterations in the structure of heterochromatin may be a major underlying cause of cellular aging.

The oxidative alteration of the target proteins is only temporary and does not cause any damage.

Such alterations are normally caused by aging but can also result from environmental factors and lifestyle.

These stroke - related alterations in the cervical spinal cord indicate pervasive and long - lasting BSCB damage that would severely affect spinal cord function, wrote the researchers, adding that the widespread microvascular impairment in the gray and white matter of the cervical spinal cord aggravated motor neuron deterioration and had the potential to cause motor dysfunction.

In addition, brain imaging studies in rats and humans have shown alterations in gray matter volume and white matter integrity in the brain caused by the effects of chronic pain.

The article focuses mainly on patients with cancer, who often undergo treatments that can cause profound alterations in the gut microbiota and potentially contribute to the development of complications.

In 2004 Yinon Ben - Neriah and Eli Pikarsky of the Hebrew University of Jerusalem and their colleagues reported that mice engineered to develop hepatitis (which can cause liver cancer) contracted precancerous lesions that did not progress to full malignancy when NF - kB was curtailed through a genetic alteration or when the proinflammatory TNF signaling molecule was shut off.

«The severe contamination of archaeological material has no precedent in the history of cultural heritage and caused irreversible alteration to the archaeological materials with enormous loss of scientific information,» the scientists wrote.

On the contrary, we found that strong inhibition of BACE1 in mice causes structural and functional synaptic alterations with deterioration of cognitive performance.»

Douglas Thomas, associate professor of medicinal chemistry and pharmacognosy at UIC, and co-workers discovered that nitric oxide plays an important role in epigenetics — heritable alterations in gene expression caused by mechanisms other than changes in DNA sequence.

Meanwhile, other groups developed new ways of killing bacteria with vancomycin: One alteration found a novel way to halt cell wall construction, whereas another caused the outer wall membrane to leak, leading to cell death.

Using clinical, genetic, and gene expression data as filters to distinguish genes whose copy number alteration causes cancer from those for whom copy number changes are incidental, the team whittled down their list from 14,000 to a more manageable number, each of which they systematically tested using genetic experiments in animals.