Sentences with phrase «cause cytokine release»

CAR - T approaches involve reengineering T - cells to find and destroy cancer cells, but that process can cause cytokine release syndrome (CRS), a life - threatening immune response NantKwest hopes to sidestep.

Not exact matches

CAR - T treatments, including competing products from Novartis rivals Kite Pharma and Juno Therapeutics, come with the risk of potentially deadly side effects such as cytokine - release syndrome (CRS), in which a glut of T - cell - assisting cytokines can cause high fever, low blood pressure, and problems with lung oxygenation.

In the absence of pain, morphine interferes with normal body function and is viewed as a pathogen, activating the brain's innate immune cells and causing the release of inflammatory chemicals such as cytokines.

One of the limitations of earlier compounds was their tendency to cause iNKT cells to release a rush of different cytokines.

As wounds heal, white blood cells, such as those called macrophages, are attracted to the wound site and release substances called cytokines that cause an inflammatory response.

Building on that work, the current paper looked at a less lethal strain, the H1N1 «swine flu,» that does not infect neurons, but which, the researchers showed, still caused inflammation in the brain via inflammatory chemicals or cytokines released by immune cells involved in fighting the infection.

They can provide a range of beneficial effects, such as lowering inflammatory cytokines (chemicals released by the immune system that can cause problems in rheumatoid arthritis patients), reducing joint stiffness and pain, as well as lowering oxidative stress — the ability of the body to counteract or detoxify harmful chemicals.

This causes the body's white blood cells to release type 1 interferon - alpha, a small cytokine protein that acts as a systemic alarm, triggering a cascade of additional immune activity as it binds with receptors in different tissues.

Watkins» work with glia, for example, has indicated that long - term opioid therapy may have an effect similar to that of chronic inflammation, causing glial cells to release an excess of cytokines that actually reduce the drug's effectiveness in blocking pain.

In a typical immune response, for instance, inflammatory proteins called cytokines will be released by immune cells at a site of inflammation and then other immune cells will use these cytokines like a trail of breadcrumbs to home in on the site of infection and destroy the pathogens that are causing it.

As they die, these cells release proteins, called cytokines, that cause inflammation and that attract healthy cellular targets promoting repeated rounds of infection and cell death.

This brain inflammation is caused by the release of cytokines, chemical messengers in the body that trigger an immune response, similar to a viral infection.

An up - regulated inflammation system causes the release of even more cytokines, which activate a hormone - like compound called c - Jun Terminal Kinase (JNK) that can cause the cells to take in less blood sugar for energy.

Exercise causes the release of helpful chemical messengers called cytokines as well as chemicals that are responsible for elation called endorphins.

Because of the dysfunction caused by the cytokines, these regulatory messengers are released based on an incorrect interpretation by the brain of the hormone environment.

In the lab, tests revealed that exposure to refined salt causes Th17 cells to release up to 10 times more cytokines than normal.

Diet - induced inflammatory reactions cause mediator release (cytokines, histamine, leukotrienes, prostaglandins, etc.) from various white blood cells (lymphocytes, neutrophils, monocytes, eosinophils).

The release of inflammatory cytokines, or intercellular signaling molecules such as interleukin - 1 (IL - 1), interleukin - 2 (IL - 6), and tumor necrosis factor alpha (TNF - α) at the site of immune activation causes other immune cells migrating throughout the lymphatic vessels of the body to express more cell adhesion molecules (CAMs).

Having chronic inflammation causes a cascade of events — including release of inflammatory markers called cytokines.

These reactions cause a release of cytokines and interleukins — which exacerbate the inflammatory response, opening the door for conditions like cancer.

It measures the inflammatory response and subtle changes in our immune cells (lymphocytes, neutrophils, monocytes, and eosinophils) as they release chemical mediators (a substance released from cells, e.g., cytokines, histamine, leukotrienes, prostaglandins, etc.), that regulate or cause physiologic consequences during an immune response to an antigen.

The general ill health (cachexia) that malignant tumors and may other serious health issues cause can lower blood cholesterol levels in a variety of ways (cytokine release, poor appetite, etc.).

CBD has been shown to decrease the production and release of inflammatory cytokines that can cause allergies, hypersensitivities and autoimmunity.