Sentences with phrase «cause decreased ability»

This can cause decreased ability to fight infection and can possibly inhibit the blood's ability to clot resulting in bleeding.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

In one recent study, Choi and several colleagues wrote that smartphone addiction, like other impulse - control disorders, can «interfere with school or work; decrease real - life social interaction; decrease academic ability; and cause relationship problems.»

Breast milk jaundice can be caused by substances in mother's milk that decrease the infant's liver's ability to deal with bilirubin.

To a large extent, state fiscal policies have caused great pressure on property taxes in needy cities, counties and school districts, including decisions: to reduce revenue sharing; to decrease the share of local school budgets covered by state aid, to divide the non-federal share of Medicaid costs without considering ability to pay, and to allocate STAR benefits... (read more)

«High maternal stress causes paternal stress, and high maternal stress decreases the child's ability to benefit from treatment,» she said.

Although testosterone levels and the ability to perform self - care activities both decrease with age, it is unclear whether one or the other is a cause or an effect of aging, or if they are both due to a common third cause, Hsu said.

As we age, loss of lens accommodation causes presbyopia — decreased ability to focus on close - up objects.

The elevation is caused by insulin resistance (decreased ability of the body to respond to insulin) and by decreased insulin production by the pancreas.

When you drink, your body is busy metabolizing the alcohol and this decreases its ability to metabolize fats and carbohydrates as effectively — causing your metabolism to slow.

In addition to slowing your ability to burn fat, hypothyroidism will also decrease your energy, causing debilitating fatigue.

The problem is, that since we've shown that cholesterol doesn't necessarily cause heart disease, and that cholesterol is necessary for cell regeneration, hormone synthesis and many other important jobs in the body, decreasing the body's ability to produce cholesterol might be (and is) the wrong approach!

But doing this right is often overlooked, and is one of the biggest causes of extended illness, extended recovery time (for injuries) and a real decrease in your ability to come back 100 %.

Dehydration causes muscle fatigue and cramping, and the body's ability to thermoregulate (maintain body temperature) is decreased.

So getting stressed about your expected results and how fast they're going to happen can also cause our stress hormones to rise, which in turn promotes storage of more belly fat, decreases our ability to get good rest and decreases quality of life and life enjoyment.

Soy has been linked to many issues due to its potential for increase or decreasing estrogen, creating thyroid issues, and its ability to cause toxic side effects.

For older age groups, vitamin B12 is often caused by the decreased ability of the digestive system to absorb nutrients.

The chronically stressed mice had decreased immune function and experienced tumor development significantly earlier than the non-stressed mice.16 Other mouse studies of ovarian cancer showed that chronic stress resulted in increased cancer growth as well as increased angiogenesis, the process with which cancer forms new blood vessels to feed itself nutrients for growth and metastases.17 Chronic stress has also been shown to decrease our body's ability to mount an attack against foreign invaders, including viruses.18 As we know that several viruses can cause cancer (HPV and cervical cancer, and EBV and nasopharyngeal cancer), we can extrapolate that any decrease in immune function could increase cancer risk.

Not only will you decrease the range of motion of the exercise, limiting your ability to build muscle fast, you may put undue stress on the shoulder girdle, causing injury.

It produces a hormone that's gonna cause fats — it's gonna basically produce leptin which is another hormone that's gonna decrease our body's ability to signal satiation and signal that we're full, which is another thing, and it's also gonna produce more sex hormones like estrogen.

Aging - associated increases in oxidative damage to key enzymes results in their structural deformation and decreased binding affinity for the co-enzyme, causing a decrease in enzyme funtion.8 Ames» research has demonstrated that increasing the availability of acetyl L - carnitine and α - lipoic acid, two nutrients that serve as mitochondrial enzyme co-factors, restores the velocity of the reactions (KM) in the related enzymes, and thus restores aging mitochondria's ability to produce youthful levels of ATP.9 10 11 12 13 Part II focused on the inter-relationships among the folate, methylation and transsulfuration pathways, whose dysfunction results in increased free radical production coupled with disruption of glutathione (GSH) synthesis, thus accelerating mitochondrial decay and aging.

When muscle is lost, so is stability and ability to provide yourself with care, causing a decrease in quality of life and potentially increasing risk of injury or death due to complications from falls.

This is VERY important... Many athletes don't realize that there are muscles that aren't used when jumping that will cause «resistance» and decrease your jumping ability.

When regions of the E. coli genome known to be involved in DNA damage were removed, the ability of the E. coli to cause tumors was substantially decreased.

Researchers have also found that increasing the number of beneficial bacteria causes cholesterol levels to decrease, due to the ability of bacteria to turn dietary fiber into the short - chain fatty acids that inhibit cholesterol.

Interestingly, CoQ10 seems to have the ability to decrease the muscle aches and weakness that can accompany use of statin drugs — troublesome symptoms that cause a significant amount of patients to stop statin treatment.

Infertility can cause stress and stress has the ability to decrease fertility so here are 4 great ways to manage stress during infertility.

Histamine tends to have a bad reputation because it is released during allergic reactions, causing a runny nose, watery eyes, decreased breathing ability, hives, and other typical allergy symptoms.

The combination of decreasing public funding for higher education, spiking tuition rates and the rise of for - profit colleges «should cause policymakers to give people back the ability to have bankruptcy courts treat their student debts like any other debt,» Kelleher said.

Every heat cycle, there's a natural reduction of white cells from the uterus to allow for safe sperm passage, causing a lapse in protection that can decrease the ability to fight infection.

Any medical or degenerative illness that causes pain, discomfort or decreased mobility — such as arthritis, dental disease, thyroid dysfunction, cancer, impaired sight or hearing, or urinary tract disease — can lead to increased sensitivity and irritability, increased anxiety about being touched or approached, increased aggression (because your cat may choose to threaten and bite rather than move away), decreased responsiveness to your voice, reduced ability to adapt to change, and reduced ability to get to usual elimination areas.

After estrus, progesterone levels remain high for 8 - 10 weeks causing thickened uterine lining and decreased ability of uterine walls to contract.

As is the case with all influenza viruses, there is the opportunity for changes in the virus that could affect transmission rates and increase or decrease the ability of the virus to cause respiratory illness.

But I believe that boredom, confinement, loneliness, separation anxiety and decreased ability to move about and interact with their environment are the root causes of most cases I see in pets.

All of the colonies will pay Tylium every turn directly into your coffers, but this amount isn't set as it can decrease due to a lack of faith in your abilities or because a Cylon fleet is currently sitting above the planet causing problems.

ie does a slightly lower density of air mean a slightly lower ground level temperature (temperature normally decreases with height at the lower air density), so that in reality adding CO2 and subtracting more O2 actually causes miniscule or trivial global COOLING, and the (unused) ability of the changed atmosphere to absorb radiation energy and transmit it to the rest of the air is overruled or limited by the ideal gas law?

While these dead zones are often caused by fertilizer runoff currently, it seems the decreasing ability of the oceans to hold dissolved oxygen with continued warming will increasingly become a problem for marine ecosystems and fisheries in the coming decades.

Given that TBI often results in decreased occupational and functional abilities, the psychological and social impact of TBI should not be overlooked as a cause of depression.

The complexity of these shadow fund valuations led to improper valuations, which caused a decrease in ability to uphold secondary guarantee provisions.

The census shows that most of the driving related accidents were caused by poor judgment in making left - hand turns; drifting within the traffic lane; and decreased ability to change behavior in response to an unexpected or rapidly changing situation.

Bowlby had earlier proposed in his maternal deprivation hypothesis published in 1951 that maternal deprivation would not only cause depression in children, but also acute conflict and hostility, decreasing their ability to form healthy relationships in adult life.

If you buy a rental property solely for the cash flow, the property's ability to sustain steady, positive income may decrease thanks to the same market conditions that cause a property's value to decrease: decline in population, loss of jobs or industry, extreme vacancy, low tenant quality, and so on.