Sentences with phrase «cause epigenetic changes»

But the data demonstrates that tea can cause epigenetic changes in women.

Research has shown that shortages or excesses of food during a person's childhood can cause epigenetic changes that lead to diabetes, obesity and early puberty.

Researchers found that particles in exhaust from cars and trucks can cause epigenetic changes — alterations that affect how genes are switched on and off without changing the DNA sequence itself.

As such, we've already figured out how some factors cause epigenetic changes.

Experiments have also shown how foods can cause epigenetic changes in the womb.

«We know that environmental stress can cause epigenetic changes — modifications to our DNA — that are passed along to future generations,» said Ocorr.

This causes epigenetic changes that can be passed down from generation to generation through affected maternal genes.

Imagine a mother who smokes around her infant daughter, causing epigenetic changes in her daughter that persist into adulthood, even if she moves away.

A new study shows that the choice of fat causes epigenetic changes which in turn could contribute to differences in fat storage.

Still, the researchers can't be certain that the mother's diet caused the epigenetic changes.

Their activation of innate immune signaling caused epigenetic changes that were absolutely necessary for the transformation of somatic cells into iPSCs,» explained Cooke, who holds the Joseph C. «Rusty» Walter and Carole Walter Looke Presidential Distinguished Chair in Cardiovascular Disease Research.

Not exact matches

Epigenetics are heritable changes caused by factors other than DNA.

These epigenetic changes caused the mice to over-respond to estrogen throughout adulthood, long after the BPA exposure.

«Our study suggests that epigenetic changes to cells treated with cigarette smoke sensitize airway cells to genetic mutations known to cause lung cancers,» says Stephen Baylin, M.D., the Virginia and D.K. Ludwig Professor for Cancer Research and professor of oncology at the Johns Hopkins Kimmel Cancer Center.

In the new research, the UB scientists found they could reverse those social deficits with a very low dose of romidepsin, which, they found, restores gene expression and function using an epigenetic mechanism, where gene changes are caused by influences other than DNA sequences.

Experience may contribute to mental illness in a surprising way: by causing «epigenetic» changes — ones that turn genes on or off without altering the genes themselves

The bacteria Helicobacter, believed to be a cause of stomach cancer, has been shown to trigger potentially cancer - inducing epigenetic changes in gut cells.

They also linked two of tobacco smoke's effects — methylation and asthma — suggesting that smoke - induced epigenetic changes could cause asthma as well.

These epigenetic modifications do not change the genetic code, but may contribute to the inhibition of gene expression, causing the cells to produce smaller amounts of the corresponding proteins.

Stress is thought to cause «epigenetic» changes to genes, which do not alter the sequence of their DNA but instead leave chemical marks that dictate how active genes are.

The researchers proved that this was caused by chemical «epigenetic» changes to parts of the gene that codes for Hnf4a, making it less active than it should be.

With epigenetics we mean such changes in genes that are not determined by changes in the actual DNA sequence, but effects that are superimposed on this, caused for example by environmental effects.

Epigenetic changes beyond a normal expression pattern can cause a variety of diseases.

It might be possible then to link the alterations to environmental changes such as stressful events or diet, which have been shown to cause inheritable epigenetic changes in mice.

The finding is some of the first direct evidence that epigenetic changes can cause cancer.

After all, it could be argued, what if the epigenetic changes observed in the rats» brains were not directly causing the behavioral changes in the adults, but were merely co-occurring?

A growing body of evidence suggests that environmental stresses can cause changes in gene expression that are transmitted from parents to their offspring, making «epigenetics» a hot topic.

«Our results therefore indicate that the increased disease risk associated with smoking is partly a caused by epigenetic changes.

Previously, she and colleagues first implicated mGlu2 in depression when they showed that a promising potential treatment known as acetyl carnitine rapidly alleviated depression - like symptoms in rats and mice by reversing these epigenetic changes to mGlu2 and causing its levels to increase.

In order to understand these effects more precisely, Neher and cowork - ers investigated epigenetic changes in the microglia, i.e. chemical modi - fications to the DNA or its packaging proteins that cause certain genes to become more or less active.

Douglas Thomas, associate professor of medicinal chemistry and pharmacognosy at UIC, and co-workers discovered that nitric oxide plays an important role in epigenetics — heritable alterations in gene expression caused by mechanisms other than changes in DNA sequence.

Fernald's work suggests that epigenetic processes may cause, rather than simply reflect, changes in dominance status in hierarchically organized species, said Tom Boyce, a professor at the University of California, San Francisco School of Medicine, who was not involved in the study.

The results show that enhancer transcription causes long - term epigenetic changes in cells.

One of the mechanisms driving alterations in gene expression is epigenetic change, where the female is able to change her offspring's genome to cause certain genes to be expressed differently.

Changing the epigenetic code of a single gene is enough to cause a healthy breast cell to begin a chain reaction and become abnormal, according to research by Queen Mary University of London (QMUL).

Using a CRISPR - dCas9 epigenetic editing tool, the researchers methylated different genes in healthy breast cells and found that those changes were sufficient to cause the cells to undergo «hyperproliferation» — abnormally rapid cell division which is an early stage of tumour initiation.

In order to work out which is the chicken and which is the egg, i.e. whether the epigenetic changes are a consequence of the disease or if the disease is a result of the changes, the researchers also investigated whether healthy individuals had epigenetic changes caused by age, BMI and raised blood sugar levels.

But in that study, the authors could not determine whether the epigenetic changes were a consequence of being overweight or the cause of the obesity in the first place.

But because the vinclozolin - induced fertility changes occurred in almost every male rat descended from a treated mother rather than in a small percentage of offspring (as is seen in germ line mutations caused by radiation), Skinner suspects an epigenetic mechanism — a change that doesn't mutate the DNA sequence of an animal, but rather affects how genes are expressed.

Epigenetics can simply be described as temporary biochemical changes in the genome, caused by various forms of environmental impact.

While genetics deals with the DNA sequence itself and the heritable changes in the DNA (mutations), epigenetics deals with heritable traits that are not caused by mutations.

Epigenetics is the study of changes in organisms caused by modifying gene expression — by alcohol, for example — rather than alteration of the genetic code itself.

The aims of the CEMC are to define the step-wise molecular and cellular alterations that occur during the process of carcinogenesis; determine how environmental exposures cause key genetic mutations and epigenetic changes that underlie carcinogenesis; and discover the impact of environmental factors on the generation and maintenance of cancer stem cells.

For example, the discovery of cancer - causing genetic and epigenetic changes in tumors has enabled the development of therapies that target these changes as well as diagnostic tests that identify patients who may benefit from these therapies.

We recognize that the use of the oncogene myc to immortalized NSCs might have caused permanent epigenetic changes in the starting cell line that could be carried over into the iPSC stage.

«We can mimic those situations in animal models to demonstrate how certain biochemical markers, such as cortisol, may be elevated in those animals and that may also be elevated in our human population,» which may illustrate environmentally induced epigenetic changes that cause an elevated risk of colorectal cancer, Winn said.

A study led by St. Jude Children's Research Hospital shows epigenetic changes that turn genes on and off are as unique as alterations in DNA and may be as important in causing the most common childhood cancer

The field of epigenetics provides crucial understanding about the ways that changes to genes caused by environmental factors drive disease, specifically chemical modifications on DNA and surrounding proteins that can alter the ways in which genes are expressed, even without the gene itself experiencing a mutation.

These comprehensive epigenomic profiles enable us to understand the cause, function, and consequence of cancer - specific epigenetic changes.

Changes in an epigenetic mechanism that turns expression of genes on and off may be as important as genetic alterations in causing pediatric acute lymphoblastic leukemia (ALL), according to a study led by scientists at St. Jude Children's Research Hospital and published in the June 10 online edition of the Journal of Clinical Investigation.