Sentences with phrase «cause of a particular disease»

In an ideal world, people's entire genomes would be mapped to find a potential root cause of a particular disease, but that is very expensive and the technology isn't ready for the clinic.

For instance, literally countless trials must be undertaken to ensure that a newly synthesized drug acts correctly on inhibiting a particular molecular pathway, and countless experiments must be performed to ensure the responsibility of that pathway as the cause of a particular disease.

A disease is usually a more general term because there can be many causes of a particular disease.

Not exact matches

«What we generally see,» says the Canadian - born Katzmarzyk, «is that people who sit more during the day have a higher risk of dying from any cause, and in particular, mortality from heart disease.»

Diagnoses were made on the basis of symptoms, and persons with a certain cluster of symptoms were given a label in the conviction that a particular cause might be found for that «disease.»

In particular, much of our Division's past research has focused on vaccine studies and investigations into the cause of Kawasaki disease.

«We found that a particular vaginal bacterium, Gardnerella vaginalis, did not cause infection during exposure to the urinary tract, but it damaged the cells on the surface of the bladder and caused E. coli from a previous UTI to start multiplying, leading to another bout of disease,» said the study's senior author, Amanda Lewis, PhD, an assistant professor of molecular microbiology and of obstetrics and gynecology at Washington University.

Infants in particular are susceptible to a number of diseases caused by gastrointestinal bacteria, including sepsis, chronic diarrhea, and necrotizing enterocolitis, an infection of the intestinal lining that is one of the leading causes of death in premature babies.

Although more than 250 different Aspergillus species are found in nature, and most contribute spores to the air we breathe, over 80 % of human disease is caused by one particular culprit called Aspergillus fumigatus.

«My part of it was basically to identify what gene was being activated by a particular effector from the bacteria in order to cause disease,» he said.

Instead, alcohol - dependent patients at all stages of liver disease had dramatic overgrowths of one fungal type in particular — Candida, which includes the species that causes yeast infections.

«The immune system gets fooled into activating this particular immune defense, and it causes harm,» says Niranjan Bhat, an infectious disease physician at Johns Hopkins Children's Center in Baltimore, Maryland, who was not part of the research.

Yet, hunting in particular may continue to cause increases in zoonotic disease risk because of the selective nature of losses following hunting.

«In particular, his approach can be thought of as a very advanced biological therapy for the treatment of breast cancer; one that uses viruses, which are better recognized to cause disease, to treat human breast cancers.»

The current study establishes that the particular strain of prions, responsible for mad cow disease, is, in fact, the same strain that causes new variant Creutzfeldt - Jakob disease.

We design short interfering RNA (siRNA) molecules that are able to trigger the RNAi pathway and mediate the degradation of specific target messenger RNAs (mRNAs), resulting in the expression of a particular disease - causing gene being inhibited.

Friedreich's ataxiais an inherited disease that causes progressive damage to the nervous system, resulting in symptoms ranging from gait disturbance to speech problems; it can also lead to heart disease and diabetes.The ataxia of Friedreich's ataxia results from the degeneration of nerve tissue in the spinal cord, in particular sensory neurons essential (through connections with the cerebellum) for directing muscle movement of the arms and legs.

«In particular, our identification of key segments of the genome that contribute to this process will hopefully allow us to identify the genetic causes of many forms of congenital heart disease — an important first step in the fight against this devastating disease.»

Many existing treatments for malaria - one of the deadliest infectious diseases - target only one stage of the complex life cycle of the Plasmodium parasite that causes the disease, and are further limited by the emergence of drug resistance in particular strains.

In particular he has worked on finding disease loci for major eye malformations: identifying the major cause as heterozygous, de novo, loss - of - function mutations in SOX2.

A new study details the minute changes — down to the level of individual atoms — that cause a particular protein to form cell - damaging clumps associated with ALS and other diseases.

Acute myeloid leukemia (AML) is the leading cause of leukemia mortality in the United States.1 Curative treatment involves intensive induction chemotherapy, before proceeding to either consolidation chemotherapy or allogeneic stem cell transplantation based on the patient's risk for relapse.2 This approach has been employed for > 4 decades and, although most individuals achieve complete remissions with front - line therapy, 3 the majority of patients ultimately relapse with drug - resistant disease, and overall survival rates remain disappointingly poor.4 The limited ability of many patients to tolerate the intense chemotherapy - based treatments, in particular hematological toxicity, further contributes to the poor outcomes noted in this disease.

In particular, Hashimoto's Thyroiditis in this first variation is an autoimmune disease that causes hypothyroidism, and is typically characterized by detection of elevated levels of anti-thyroid peroxidase antibodies in serum from the patient.

For a better understanding of how acidosis leads to osteoporosis in particular, let us see how body over-acidity or acidosis causes chronic diseases in general.

Dr. Tom Cowan brings some surprising data to light that puts into question the cause and treatments of cardiovascular disease, and heart attacks, in particular.

Regardless of the particular disease, the underlying cause is an overactive immune system, which explains why autoimmune disorders are commonly treated with steroids and other immune - suppressing medications.

Many people struggle with disorders of the digestive tract, including those that cause discomfort and inflammation like irritable bowel syndrome, Crohn's disease, celiac disease, acid reflux, ulcers, and just plain old indigestion with no particular diagnosis.

In particular, these handouts cover the following specific content about tuberculosis in South Africa: Case study of one communicable disease, such as malaria or tuberculosis, at a country scale, either an LIDC or EDC, including: o environmental and human causes of the disease o prevalence, incidence and patterns of the disease o socio - economic impacts of the disease o direct and indirect strategies used by government and international agencies to mitigate against the disease and respond to outbreaks.

Fairly prevalent in goldfishes, swim bladder disease is when the organ maintaining the fish's stability and bouyancy loses its ability to regulate air properly, causing the fish to float nearer to the surface of the water, swim towards a particular side, or even end up upside down!

This particular disease is often the cause of unknown fevers.

Contact Dermatitis is a fairly uncommon disease caused by direct contact of your pet's skin with certain plants and grasses, medications, and particular chemicals.

Click on any disease type below for more information about the definition, risk factors, causes, symptoms, diagnosis, treatment, and prognosis of that particular form of cancer.

Contact dermatitis is a fairly uncommon disease caused by direct contact of your pet's skin with certain plants and grasses, medications, and particular chemicals.

Humans also have bacteria in their mouths, but cats can pass on particular forms of bacteria — including one that causes «Cat - Scratch Disease,» an infection that generally does not cause serious symptoms in healthy adults.

Dirofilaria immitis is particular specie of heart worm and is considered to be the cause of heart worm disease in dogs.

Pets don't complain; but gum disease and tartar are the causes of the strong breath of you notice as your pet ages and, in dogs in particular, it accounts for lost teeth, drooling and painful chewing.

«Chronic kidney disease [CKD] in particular is a common cause of morbidity and mortality in older dogs and cats.

Immature heartworms can still cause damaging effects, in particular, in the form of a disease called heartworm associated respiratory disease (HARD).

A version of Coccidia, called Toxoplasmosis, is of particular significance to pregnant women since it can cause disease in unborn children.

Ringworm, more correctly called dermatophytosis, is a contagious disease caused by an infection of the skin, fur and / or nails with particular types of fungi.

Frequency of the gene mutations that cause a particular disease should be a major consideration.

This comprehensive and practical book is designed to assist cat owners in understanding their pets» bodies and health based on signs and symptoms of disease, and in determining the most common medical problems that might cause particular symptoms.

Diet - related nutrogenic diseases can be aggravated when various food ingredients alter the health - promoting population of bacteria in the digestive system, the «microbiome» or «garden of the guts,» and when a particular breed or individual genome has gene - related processes and reactions to food ingredients that cause or aggravate illness.

«As an organisation that sees the extreme levels of damage that alcohol causes in our hospitals every day — not just in terms of accidents and injuries, but in terms of chronic disease and illness — we welcome the budget's extra funding to combat Foetal Alcohol Spectrum Disorder (FASD), with a particular focus on rural and remote Aboriginal and Torres Strait Islander communities.

Workload, in particular tight deadlines, too much work and too much pressure or responsibility, a lack of managerial support, organisational changes at work, violence and role uncertainty are identified causes of work - related stress.1 These factors are antecedents of sickness presenteeism which is mediated by mental and physical health.2 At the individual level, chronic stress produces long - term deleterious effects in health, namely, cardiovascular diseases, 3 burn - out, anxiety and depression.4 Sickness absence in Europe is associated with psychosocial work factors.5 The link between work performance, stress and health poses an important challenge to workers, employers and organisations in general, as stress should be monitored and mitigation measures implemented accordingly.6

Women and older couples, in particular, seem to be more susceptible to increased rates of heart disease caused by marital stress.