Dietary exposure to the cyanotoxin BMAA is suspected to be
the cause of amyotrophic lateral sclerosis in the Western Pacific Islands.
Not exact matches
Drink One for Dane, held every May, in honor
of late Co-founder Dane Boersma, which raises funds for research into
cause and cure for
amyotrophic lateral sclerosis (ALS) and support for families facing the realities
of the disease.
The same treatment killed many other types
of neurons, including both the spinal motor neurons that die in
amyotrophic lateral sclerosis and the human dopaminergic neurons whose mysterious loss is the
cause of Parkinson's disease.
Scientists at Mayo Clinic, Jacksonville, Florida created a novel mouse that exhibits the symptoms and neurodegeneration associated with the most common genetic forms
of frontotemporal dementia (FTD) and
amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), both
of which are
caused by a mutation in the a gene called C9ORF72.
A study published Tuesday in eLife reports the results
of a system that enabled three participants — Degray and two people with
amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease, a neurodegenerative disease that
causes progressive paralysis)-- to type at the fastest speeds yet achieved using a BCI — speeds that bring the technology within reach
of being practically useful.
Johns Hopkins researchers say they have discovered some
of the first steps in how a very common gene mutation
causes the brain damage associated with both
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
The most common genetic
cause of the brain diseases frontotemporal dementia (FTD) and
amyotrophic lateral sclerosis (ALS) is a mutation in the C9orf72 gene.
Using a mouse model, his work is beginning to elucidate a mechanistic understanding
of a form
of amyotrophic lateral sclerosis that is
caused by protein misfolding.
With colleagues Timothy Miller, M.D., Ph.D., UCSD Department
of Neurosciences, and Richard A. Smith, M.D.,
of the Center for Neurologic Study, Cleveland found that when effective doses
of the antisense therapy were delivered, far less
of a protein that
causes a hereditable form
of amyotrophic lateral sclerosis was produced.
However, age - dependent neurodegeneration is very prevalent, as many diseases such as Alzheimer's, Parkinson's,
Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's disease), and prion diseases (that
cause «mad cow» disease), are diseases
of neuronal death.
A failure
of normal astrocyte generation by CNS precursor cells has been discovered to be a consequence
of the mutations that
cause Vanishing White Matter leukodystrophy [7], and dysfunction
of astrocytes has also been suggested to be
of importance in models
of amyotrophic lateral sclerosis [8], forebrain ischemic injury [9], epileptic seizures [10], Huntington's disease [11], tuberous
sclerosis [12] and Rett syndrome [13].
Researchers have tied mutations in a gene that
causes amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders to the toxic buildup
of certain proteins and related molecules in cells, including neurons.
While people may have written off the «ice bucket challenge», used to raise money and awareness for
Amyotrophic Lateral Sclerosis (ALS) or Lou Gehrig's disease, as just a social media flash in the pan, the money raised by people participating in the challenge and their supporters funded the research that led to the discovery
of the gene (NEK1) that
causes ALS.