Not exact matches
Four years ago, she was diagnosed with
pulmonary fibrosis, a condition that
causes scarring in the lungs and results in increasing shortness of breath.
«To our knowledge, this is the first direct evidence that Akt1
causes disease onset and progression of
pulmonary fibrosis and
pulmonary hypertension,» Shenoy said.
Although no definitive
cause for the disease has been identified,
pulmonary fibrosis affects nearly 130,000 people in the U.S., with about 48,000 new cases diagnosed annually, according to the Coalition for Pulmonary
pulmonary fibrosis affects nearly 130,000 people in the U.S., with about 48,000 new cases diagnosed annually, according to the Coalition for Pulmonary F
fibrosis affects nearly 130,000 people in the U.S., with about 48,000 new cases diagnosed annually, according to the Coalition for
Pulmonary Pulmonary FibrosisFibrosis.
Researchers at UT Southwestern Medical Center have identified mutations in two genes that
cause a fatal lung scarring disease known as familial
pulmonary fibrosis.
The disease often is called idiopathic
pulmonary fibrosis because, in most cases, the
cause can not be found.
«Study finds
cause of
pulmonary fibrosis in failure of stem cells that repair lungs.»
«Inhibiting DGKi seems to reverse the effects of cystic
fibrosis, but not block ENaC completely,» says Margarida Amaral from the University of Lisboa, «indeed, inhibiting DGKi reduces ENaC activity enough for cells to go back to normal, but not so much that they
cause other problems, like
pulmonary oedema.»
Pulmonary fibrosis causes the patient's lung tissue to scar, resulting in progressive pulmonary function deter
Pulmonary fibrosis causes the patient's lung tissue to scar, resulting in progressive
pulmonary function deter
pulmonary function deterioration.
Palmer said the multi-site registry will help doctors who treat patients with idiopathic
pulmonary fibrosis better understand how to diagnose and manage the disease, while it will also help researchers uncover the basic
causes and mechanisms of the disease.
It also shows some overlap between the genetic
causes of COPD and those of the less common but severe disease, idiopathic
pulmonary fibrosis.
Diseases affecting the lung, including emphysema, cystic
fibrosis, acute respiratory distress syndrome and
pulmonary fibrosis,
cause considerable morbidity and mortality in the U.S.. However, there are not many treatment options available for those diseases, in part due to the limited availability of human lung cells for research.
The report mentioned that the gene could even «shed light on the
causes of lung injuries» but turned out they were talking about «injuries» like pneumonia, inflammation or
pulmonary fibrosis.