Smoothened (Smo) is a 7TMR that mediates effects of Hedgehog on developmental processes and whose dysregulation may
cause tumorigenesis.
Not exact matches
Aneuploidy is found in most solid tumours, but it remains unclear whether it is the
cause or the consequence of
tumorigenesis.
Uterine leiomyomas, also called fibroids,
cause a very significant burden to women's health but relatively little has been known about the mechanisms of
tumorigenesis involved.
We also demonstrated that this observation was not
caused incidentally by a particular vectoring system: using intraductal injection of a lentiviral vector (Bu et al., 2009) to introduce caErbb2 to ductal epithelia, we also observed accelerated
tumorigenesis in the parous group relative to the virgin group (Figure 1 — figure supplement 2).