Sentences with phrase «caused by cancer cells»

«Brain metastases are a secondary brain tumour, which means they are caused by cancer cells that escape from primary tumours like lung, breast or melanoma, and travel to the brain,» said Mohini Singh, the study's primary author and a PhD candidate in biochemistry at the Michael G. DeGroote School of Medicine at McMaster.

Not exact matches

The oxidative damage caused to normal cells by free radicals has been linked to chronic conditions like cancer, heart disease, and degenerative diseases related to aging.

Carcinogens may cause cancer by altering cellular metabolism or damaging DNA directly in cells, which interferes with normal biological processes.

The spread of cancer by metastasis is driven by a set of mutant proteins called oncogenes which cause cancer cells to multiply uncontrollably and promotes their ability to move.

The most common type of skin lymphoma is caused by the fact that specific immune cells — CD4 - T - lymphocyttes — turn into cancer cells.

«We've long known that NF - kB promotes cancer development by subverting apoptosis, an internal safety mechanism that otherwise would cause cancer cells to self - destruct,» says principal investigator Denis Guttridge, PhD, professor of molecular virology, immunology and medical genetics and of molecular and cellular biochemistry.

Also known as the «Guardian of the Genome,» p53 fights cancer by causing damaged cells to die or by halting the growth of mutant cells before they become cancerous and spread to the rest of the body.

Designing molecules that selectively target thiols produced by cancer cells that cause drug resistance is the focus of many years» work by Dimmock, Das and their collaborators.

But this ability to infect brain stem cells may prove useful for fighting deadly brain cancers, many of which are caused by mutated stem cells.

«For this reason, we decided to combine vitamin C with a PARP inhibitor, a drug type known to cause cancer cell death by blocking the repair of DNA damage, and already approved for treating certain patients with ovarian cancer.»

The research team, led by senior author Timothy P. Cripe, MD, PhD, chief of the Division of Hematology / Oncology / BMT at Nationwide Children's Hospital, found that virotherapy doesn't always require a strong virus infection of cancer cells to cause tumors to shrink or die.

Cancer is caused by uncontrolled cell division, so these effects could explain the disputed leukaemia findings.

One miRNA can target multiple genes, but their expression is often hijacked by cancer cells and disrupts multiple cancer - causing or tumor - suppressing pathways,» says Shuk - Mei Ho, PhD, director of the CCC and Jacob G. Schmidlapp Chair of Environmental Health and professor at the University of Cincinnati (UC) College of Medicine.

The time needed for breast cancer metastases (secondary lesions caused by cells that have escaped from the original tumour) to develop varies between patients, and little is known about the mechanisms that govern latency (the dormant state of cells that have already spread through the body).

Klingelhutz and his team immortalized immature precursor fat cells by adding in two genes from HPV (the virus that causes cervical cancer) along with a gene for part of an enzyme that controls the length of cells» telomeres — the pieces of DNA that protect chromosome tips from deterioration.

Findings from the study could help improve understanding of the causes of some diseases — including cancer — that are triggered by errors in the cell division process, the team says.

However, the use of NF - kB inhibitors in treating cancer is complicated by severe side effects related to immunosuppression caused by indiscriminate inhibition of NF - kB in normal immune cells.

A new study led by University of Kentucky researchers suggests that activating the tumor suppressor p53 in normal cells causes them to secrete Par - 4, another potent tumor suppressor protein that induces cell death in cancer cells.

Dr Gillian Farnie, whose work at the University's Institute of Cancer Sciences was funded by a five - year # 500,000 Breast Cancer Campaign Scientific Fellowship, said: «We know that cancer stem cells are able to avoid or repair damage caused by treaCancer Sciences was funded by a five - year # 500,000 Breast Cancer Campaign Scientific Fellowship, said: «We know that cancer stem cells are able to avoid or repair damage caused by treaCancer Campaign Scientific Fellowship, said: «We know that cancer stem cells are able to avoid or repair damage caused by treacancer stem cells are able to avoid or repair damage caused by treatment.

Findings by Cincinnati Cancer Center researchers show that levels of bisphenol A (BPA) in men's urine could be a marker of prostate cancer and that low levels of BPA exposure can cause cellular changes in both non-malignant and malignant prostate Cancer Center researchers show that levels of bisphenol A (BPA) in men's urine could be a marker of prostate cancer and that low levels of BPA exposure can cause cellular changes in both non-malignant and malignant prostate cancer and that low levels of BPA exposure can cause cellular changes in both non-malignant and malignant prostate cells.

Moreover, in some cases, pancreatic cancer cells can even repair damage to their DNA caused by the chemotherapy drugs that do get into the tumor, further protecting themselves.

Rather than artificially triggering cancer by engineering genetic mutations, this model more closely mimics human liver cancer in that tumors develop as a natural consequence of non-alcoholic steatohepatitis (NASH), a chronic metabolic disorder that causes liver damage, fibrosis and numerous cell mutations.

«You don't want to just turn down methylation globally, which would result in over-activation of all genes in the cell, but demethylating some of these gene promoter regions selectively could revive an immune system muted by cancer - causing viruses,» Kuss - Duerkop says.

Myc is a cancer - causing gene responsible for disrupting the normal 24 - hour internal rhythm and metabolic pathways in cancer cells, found a team led by researchers from the Perelman School of Medicine at the University of Pennsylvania.

Those cells become coated with peptides derived from their stealth infection by two HPV strains that cause cervical cancer.

The results challenge accepted ideas about how stem cells age and may eventually lead to new ways to prevent graying and treat the more serious conditions caused by genotoxic stress, such as cancer.

While researchers debate whether microwaves emitted by cell phones might cause brain cancer, a study published in the Journal of the American Medical Association last February raised an entirely different concern.

Dr Bernardo Tavora, lead author on the paper from the Barts Cancer Institute, said: «This work shows that sensitivity to cancer treatment is related to our own body mistakenly trying to shield the cancer from cell - killing effects caused by radiotherapy and chemothCancer Institute, said: «This work shows that sensitivity to cancer treatment is related to our own body mistakenly trying to shield the cancer from cell - killing effects caused by radiotherapy and chemothcancer treatment is related to our own body mistakenly trying to shield the cancer from cell - killing effects caused by radiotherapy and chemothcancer from cell - killing effects caused by radiotherapy and chemotherapy.

But the butyrate produced by the starch - fermenting bacteria could also directly suppress the proliferation of any potential cancer - causing cells in the lining of the large gut.

«The genome of these cancer cells is less abnormal as compared to cancers caused by tobacco and alcohol, where there are even more mutations present,» he says.

Some of the common genetic alterations identified in the study were gains and losses in chromosome 8, as well as cell proliferation and cell - cycle progression — key mechanisms of cancer caused by genetic alterations — linked to the genes AURKA, AURKB and FOXM1.

Silver says her lab will try to build such a cell that they can then implant into mammals to detect and report on the extent of harm caused by UV radiation, which damages DNA and is a risk factor in the development of cancer.

But in healthy cells, the genetic disruption triggered by chromosome clumping either kills the cell or coerces it into multiplying nonstop, causing cancer.

«The cancer stem cells actively regrow and respond to the induced damage or apoptosis (cell death) caused by chemotherapy in between the different cycles, similar to how normal tissue stem cells respond to wound - induced damages.»

The convergence of several factors explains the trend: cheaper genetic sequencing technologies, the discovery of new oncogenes (genes that can cause a normal cell to become cancerous), a new generation of computers and bioinformatics that can analyze vast amounts of data, and a multibillion - dollar effort by researchers inside and outside the pharma industry to develop targeted drugs and companion diagnostics for cancer.

A widespread cancer - causing protein called MYC promotes the growth of tumor cells in part by ensuring that RNA transcripts are properly spliced, according to latest work from A * STAR researchers.

The stem cells that proliferate the most in response to damage caused by cigarette smoke repair their DNA using a process prone to errors, setting the stage for lung cancer, according to a study publishing January 26, 2017 in the open - access journal PLOS Biology by Marie - Liesse Asselin - Labat and her team of the Walter and Eliza hall Institute of Medical Research, Australia.

«We note that there are two subgroups of breast tumors by epigenome: one which we have called Epi - Basal, characterized by loss of epigenetic marks causing breakage of chromosomes and the other that we have called Epi - Luminal B, that presents epigenetic inactivation of genes that should protect us from cancer and these altered cells can no longer do it.»

Hepatitis, steroids, birth control pills, alcohol, cancer, even gallstones can interfere with bile secretion, causing the fluid, which is made by the liver to help digest food, to stay in the liver, where it's toxic to cells, said Dr. Yisang Yoon, cell physiologist at the Medical College of Georgia at Georgia Regents University.

In the present study, the scientists demonstrated that the drug BI-97D6 increased cancer cell death caused by mda - 7 / IL - 24, and it also helped defend against resistance to the viral gene therapy.

Scientists have discovered a new «mastermind fusion gene» may be associated with a rare cancer - causing tumor — pheochromocytomas («pheo») and paragangliomas, according to a study published Feb. 13 in Cancer Cell, by researchers at the Uniformed Services University (USU) and the National Cancer Institutes» The Cancer Genome cancer - causing tumor — pheochromocytomas («pheo») and paragangliomas, according to a study published Feb. 13 in Cancer Cell, by researchers at the Uniformed Services University (USU) and the National Cancer Institutes» The Cancer Genome Cancer Cell, by researchers at the Uniformed Services University (USU) and the National Cancer Institutes» The Cancer Genome Cancer Institutes» The Cancer Genome Cancer Genome Atlas.

Given the widespread use of the HeLa cell line, Lars Steinmetz and his colleagues at EMBL decided that conducting an extensive analysis of its genome could illustrate the changes caused by cancer — and also help researchers compare versions of the cell line that have evolved over decades of growth in labs around the world.

«The actual transformation into cancer cells is caused by other, unrelated factors and can occur later.

It was originally thought that ATRA was successfully treating APL by inducing cell differentiation, causing cancer cells to change into normal cells by activating the cellular retinoic acid receptors.

The breast cancer drug palbociclib arrests cells in G1 phase by CDK4 / 6 inhibition, but also causes cellular senescence.

That doesn't mean that two - thirds of cancer cases are caused by random copying errors, they said; it can take three, four or more mutations to make a cell turn malignant.

Paper author, Professor Margaret Frame, Cancer Research UK scientist at the Edinburgh Cancer Research UK Centre, said: «We've shown that cancer cells can adapt to the problems caused by stress, by hijacking normal cell waste disposal to «bag up and bin'toxic proCancer Research UK scientist at the Edinburgh Cancer Research UK Centre, said: «We've shown that cancer cells can adapt to the problems caused by stress, by hijacking normal cell waste disposal to «bag up and bin'toxic proCancer Research UK Centre, said: «We've shown that cancer cells can adapt to the problems caused by stress, by hijacking normal cell waste disposal to «bag up and bin'toxic procancer cells can adapt to the problems caused by stress, by hijacking normal cell waste disposal to «bag up and bin'toxic proteins.

Treatment of lung cancer cell lines with mebendazole caused mitotic arrest by depolymerization of tubulin, followed by apoptotic cell death.

And some metabolic mutations, which themselves can promote cancer - causing changes in the cell, will be more successful if they're followed by mutations in tyrosine kinases or transcription factors that stimulate cell growth.

A long - standing mystery about how cells resist the powerful effects of cancer - causing genes has been solved by researchers studying a genetic check - and - balance system that prevents cells in the body...