Sentences with phrase «caused by components»

However, inflammation and metabolic stress caused by components of the tumor epithelium can result in non-genetic vulnerabilities that can be potentially exploited for the design of innovative therapeutic approaches.

The gloss is that the damages claim may still be «occasioned by a motor vehicle» if those damages were caused by a component of the motor vehicle integral to its conveyance function.

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

Actual results, including with respect to our targets and prospects, could differ materially due to a number of factors, including the risk that we may not obtain sufficient orders to achieve our targeted revenues; price competition in key markets; the risk that we or our channel partners are not able to develop and expand customer bases and accurately anticipate demand from end customers, which can result in increased inventory and reduced orders as we experience wide fluctuations in supply and demand; the risk that our commercial Lighting Products results will continue to suffer if new issues arise regarding issues related to product quality for this business; the risk that we may experience production difficulties that preclude us from shipping sufficient quantities to meet customer orders or that result in higher production costs and lower margins; our ability to lower costs; the risk that our results will suffer if we are unable to balance fluctuations in customer demand and capacity, including bringing on additional capacity on a timely basis to meet customer demand; the risk that longer manufacturing lead times may cause customers to fulfill their orders with a competitor's products instead; the risk that the economic and political uncertainty caused by the proposed tariffs by the United States on Chinese goods, and any corresponding Chinese tariffs in response, may negatively impact demand for our products; product mix; risks associated with the ramp - up of production of our new products, and our entry into new business channels different from those in which we have historically operated; the risk that customers do not maintain their favorable perception of our brand and products, resulting in lower demand for our products; the risk that our products fail to perform or fail to meet customer requirements or expectations, resulting in significant additional costs, including costs associated with warranty returns or the potential recall of our products; ongoing uncertainty in global economic conditions, infrastructure development or customer demand that could negatively affect product demand, collectability of receivables and other related matters as consumers and businesses may defer purchases or payments, or default on payments; risks resulting from the concentration of our business among few customers, including the risk that customers may reduce or cancel orders or fail to honor purchase commitments; the risk that we are not able to enter into acceptable contractual arrangements with the significant customers of the acquired Infineon RF Power business or otherwise not fully realize anticipated benefits of the transaction; the risk that retail customers may alter promotional pricing, increase promotion of a competitor's products over our products or reduce their inventory levels, all of which could negatively affect product demand; the risk that our investments may experience periods of significant stock price volatility causing us to recognize fair value losses on our investment; the risk posed by managing an increasingly complex supply chain that has the ability to supply a sufficient quantity of raw materials, subsystems and finished products with the required specifications and quality; the risk we may be required to record a significant charge to earnings if our goodwill or amortizable assets become impaired; risks relating to confidential information theft or misuse, including through cyber-attacks or cyber intrusion; our ability to complete development and commercialization of products under development, such as our pipeline of Wolfspeed products, improved LED chips, LED components, and LED lighting products risks related to our multi-year warranty periods for LED lighting products; risks associated with acquisitions, divestitures, joint ventures or investments generally; the rapid development of new technology and competing products that may impair demand or render our products obsolete; the potential lack of customer acceptance for our products; risks associated with ongoing litigation; and other factors discussed in our filings with the Securities and Exchange Commission (SEC), including our report on Form 10 - K for the fiscal year ended June 25, 2017, and subsequent reports filed with the SEC.

Among the factors that could cause actual results to differ materially are the following: (1) worldwide economic, political, and capital markets conditions and other factors beyond the Company's control, including natural and other disasters or climate change affecting the operations of the Company or its customers and suppliers; (2) the Company's credit ratings and its cost of capital; (3) competitive conditions and customer preferences; (4) foreign currency exchange rates and fluctuations in those rates; (5) the timing and market acceptance of new product offerings; (6) the availability and cost of purchased components, compounds, raw materials and energy (including oil and natural gas and their derivatives) due to shortages, increased demand or supply interruptions (including those caused by natural and other disasters and other events); (7) the impact of acquisitions, strategic alliances, divestitures, and other unusual events resulting from portfolio management actions and other evolving business strategies, and possible organizational restructuring; (8) generating fewer productivity improvements than estimated; (9) unanticipated problems or delays with the phased implementation of a global enterprise resource planning (ERP) system, or security breaches and other disruptions to the Company's information technology infrastructure; (10) financial market risks that may affect the Company's funding obligations under defined benefit pension and postretirement plans; and (11) legal proceedings, including significant developments that could occur in the legal and regulatory proceedings described in the Company's Annual Report on Form 10 - K for the year ended Dec. 31, 2017, and any subsequent quarterly reports on Form 10 - Q (the «Reports»).

Many factors could cause BlackBerry's actual results, performance or achievements to differ materially from those expressed or implied by the forward - looking statements, including, without limitation: BlackBerry's ability to enhance its current products and services, or develop new products and services in a timely manner or at competitive prices, including risks related to new product introductions; risks related to BlackBerry's ability to mitigate the impact of the anticipated decline in BlackBerry's infrastructure access fees on its consolidated revenue by developing an integrated services and software offering; intense competition, rapid change and significant strategic alliances within BlackBerry's industry; BlackBerry's reliance on carrier partners and distributors; risks associated with BlackBerry's foreign operations, including risks related to recent political and economic developments in Venezuela and the impact of foreign currency restrictions; risks relating to network disruptions and other business interruptions, including costs, potential liabilities, lost revenues and reputational damage associated with service interruptions; risks related to BlackBerry's ability to implement and to realize the anticipated benefits of its CORE program; BlackBerry's ability to maintain or increase its cash balance; security risks; BlackBerry's ability to attract and retain key personnel; risks related to intellectual property rights; BlackBerry's ability to expand and manage BlackBerry ® World ™; risks related to the collection, storage, transmission, use and disclosure of confidential and personal information; BlackBerry's ability to manage inventory and asset risk; BlackBerry's reliance on suppliers of functional components for its products and risks relating to its supply chain; BlackBerry's ability to obtain rights to use software or components supplied by third parties; BlackBerry's ability to successfully maintain and enhance its brand; risks related to government regulations, including regulations relating to encryption technology; BlackBerry's ability to continue to adapt to recent board and management changes and headcount reductions; reliance on strategic alliances with third - party network infrastructure developers, software platform vendors and service platform vendors; BlackBerry's reliance on third - party manufacturers; potential defects and vulnerabilities in BlackBerry's products; risks related to litigation, including litigation claims arising from BlackBerry's practice of providing forward - looking guidance; potential charges relating to the impairment of intangible assets recorded on BlackBerry's balance sheet; risks as a result of actions of activist shareholders; government regulation of wireless spectrum and radio frequencies; risks related to economic and geopolitical conditions; risks associated with acquisitions; foreign exchange risks; and difficulties in forecasting BlackBerry's financial results given the rapid technological changes, evolving industry standards, intense competition and short product life cycles that characterize the wireless communications industry.

By: Kimberley Smuts 27th May 2016 Fire is a pervasive threat to conveyor belt systems at mines and can cause substantial damage to the conveyed material, electromechanical components of the conveyor system and the belt if the necessary fire - protection systems are not in place.

Apple ended a rough week by announcing that a fault in some MacBook Pro laptops have a faulty component that «may fail causing the built - in...

But most of all it would have affirmed the conviction of CLAY members that the cause they served, whether by marching in DC or volunteering at a crisis pregnancy center, was a legitimate component of social justice.

The next stage was to accept that in many entities we have to consider a large number of interacting components, and processes of cause - effect which are not simply linear, but may interest either by being linked into networks, or by various types of feed - back interaction, positive or negative and so on.

Observing devices, either within the region of the dissipative structure or outside of it, may detect regular oscillations caused by variations of components of the structure, or, if their temporal or spatial resolving power is not high enough for that, they may detect only a new, averaged reading, corresponding to a novel state of affairs brought about by the closure of the set of relationships which defines the dissipative structure.

If any of these components is reduced in food products and human consumption these will leads to the Deficiency diseases for example Kwashiorkor and Marasmus caused by the deficiency of dietary proteins.

These include, but are not limited to, damages or injury caused by error, omission, defect, failure of performance, delay in operation or transmission, line failure or computer virus, worm, or other harmful component.

This warranty does not apply to normal wear and tear; soiling and staining caused by grease, inks, cosmetics, bleach, dyes, solvents, corrosives; intentional or accidental damage / abuse, (i.e. cutting into the material); misuse / mishandling of the product and any of it's components; or to mattresses that do not contain the original manufacturer's law tag.

While solely breastfed, the baby is protected by components in mother's milk that prevent foreign proteins from entering the baby's system and causing an allergic reaction.

This warranty does not apply to normal wear and tear; soiling and staining caused by grease, inks, cosmetics, bleach, dyes, solvents, corrosives; intentional or accidental damage / abuse, (i.e. cutting into the material); misuse / mishandling of the product and any of its components; or to a product that does not contain the original manufacturer's law tag.

The state Assembly is poised to take up several of the individual components of the Women's Equality Agenda as separate bills, ending a two - year impasse caused by a controversial reproductive rights plank.

«We found that growth of nanowires is not only caused by the VLS process, but also by a second component that was observed and quantified directly for the first time in this experiment.

By tuning the laser, the team were able to split up the wave, causing some of its components to bounce upwards.

BAD is caused by excessive secretion of bile acids, a component of bile that aids digestion.

Marianne Hinson, head of aerodynamics at TeamLotus in Norwich, UK, says the idea is to let drivers overcome problems due to turbulence caused by three components on the car in front.

Inclusive fitness theory assumes that the personal fitness of an individual can be partitioned into components caused by individual actions.

«The trait self - esteem of the envied employee is an important component that will determine whether they are able to recognize the behaviors of their co-workers as being caused by envy or not and this will subsequently determine their behavioral response.»

«Considering that abdominal arterial aneurysms are caused by inflammation and the degradation of elastin components in the arterial wall, we thought drinking green tea may show promise for treatment.»

Some scientists think that aging is caused by a nasty byproduct of metabolism that beats up the components of cells, much like combustion wears down engines.

But because this pathway is unique to strep and staph bacteria, the new understanding of its components could help researchers develop highly targeted antibiotics to treat infections caused by these bacteria in the future.

This avoids unnecessary delays caused by a single missing component on the day of the experiment.

The researchers developed a novel approach to the issue by using climate data from the IPCC and directly modeling all of the components that cause flooding at the coast including, waves, tides, winds blowing over the surface of the ocean and estuaries, precipitation, and stream flow.

The psychological damage caused by the attacks of September 11 mirrored the physical destruction and showed that protecting the public's mental health must be a component of the national defense

Teams from CNRS, the Université de Strasbourg and Inserm, led by Daniel Riveline [1], Jean - Marie Lehn [2] and Marie - France Carlier [3], have synthesized molecules capable of causing rapid growth of actin networks, one of the components of the cytoskeleton.

As we age, the nitric oxide meant to cause dilation is increasingly destroyed by reactive oxygen species such as superoxide, which are produced by many components of our body's own cells, including organelles called mitochondria.

The March of Dimes Prematurity Research Center — Ohio Collaborative, launched in 2013, is responsible for the gene identification component of the network of five Prematurity Research Centers nationwide established by the March of Dimes to identify the unknown causes of preterm birth.

«We hope to be able to find the exact origin of what causes polarization and the components that are being distributed in the cell by visualizing more components in the plant zygote.

Among the undiluted binaries, planet - like eclipses may be caused by grazing EBs and the (central) eclipses of two stellar components with large ratios in area or surface brightness, typically due to a large mass ratio.

In his graduate research, Linsley discovered the gene Stac3 is a component of the excitation - contraction machinery in skeletal muscle and the mechanism by which mutations in that gene cause Native American Myopathy, a rare but devastating congenital disease.

The reschedule was caused by delays and minor component qualification test issues, as well as delays stemming from a spacecraft dome element that was damaged during the manufacturing process.

You will use resources, similar to those used by researchers here at the Wellcome Trust Sanger Institute, to research the key components of the bacteria which determine their different disease - causing ability.

We also report that 5 - HT1A binding alterations correlate among components of the medullary 5 - HT system in the SIDS cases (and controls), substantiating our concept that the medullary 5 - HT system is an interrelated network that modulates respiratory and autonomic functions3 — a concept likewise increasingly supported by animal data.3,23 - 25 We now postulate that SIDS can be viewed as a disorder caused by a defect in 1 or more components of the medullary 5 - HT system and that any single case need not express defects in all 5 - HT markers simultaneously.

The analysis ensured that «all materials will stay below their temperature limits and that stresses caused by thermal expansion will be low enough to avoid component damage.»

Although insula activations are commonly observed during odor perception [33], in the present study these activations are very likely not caused by an olfactory component of the chemosensory anxiety signals.

In Figure 4, Huber and Knutti break down the anthropogenic and natural forcings into their individual components to quantify the amount of warming caused by each since the 1850s (Figure 4b), 1950s (4c), and projected from 2000 to 2050 using the IPCC SRES A2 emissions scenario as business - as - usual (4d).

The hot taste of peppers is caused by its active component called capsaicin and it can also act as powerful combatants against inflammation.

15:33 - Other symptoms that can be caused by digestive problems (skin problems, fatigue, etc) 16:00 - How every disease can be traced back to the gut 16:16 - How intestinal permeability (leaky gut) leads to disease 18:22 - How gut problems manifest differently in different people 19:22 - What causes diarrhea 20:00 - The fastest way to stop diarrhea 20:42 - Why you might not be absorbing your food 21:10 - What causes constipation 21:20 - How gut infections lead to constipation and diarrhea 22:02 - How to poop more easily 22:32 - The hormonal component of digestion 23:22 - Three things you MUST do everyday 24:03 - The major factors that harm gut health 24:32 - Why stress is so important 24:30 - The triggers of leaky gut 25:02 - Head injuries and gut health 25:32 - SIBO 25:52 - Two things to improve gut health fast 26:52 - Things to do to help your gut - paleo autoimmune diet 27:22 - One reason to binge on gluten 29:22 - Another reason to eat healthy fats 30:07 - Tips to help kids with digestive issues 30:52 - Interesting study about feeding kids candy 32:37 - The advice he wishes he'd gotten 33:22 - One action step to take now 24:55 - Resources he likes

Alfalfa leaf helps reduce the effects caused by menopause in women, such as hot flashes, as it is known to contain a component that has the effect of a natural estrogen (female hormone).

This could be attributed to a variety of reasons: blood components in meat that degrade into carbon monoxide, carcinogens created by cooking muscle or consuming processed meat, pro-inflammatory arachidonic acid and iron, huge amounts of bacteria causing inflammation, or even the antibiotics in meat adversely affecting gut flora.

Gluten sensitivity is caused by elevated levels of antibodies against a component of gluten, gliadin.

It boosts the immune system, protects vision, stops the build - up of oxidised fats, and helps to convert carbohydrates into energy and most crucially reduces the damage done to important cell components caused by reactive oxygen molecules such as free radicals and peroxides7.

The last component of your daily energy expenditure is thermogenesis which is the thermic effect caused by consuming food.

Typically, flatulence is caused by the fermentation of undigested food, or when your digestive system doesn't completely break down certain food components, such as gluten or sugar in dairy and fruit.

Claims that butter causes chronic high cholesterol values have not been substantiated by research — although some studies show that butter consumption causes a small, temporary rise — while other studies have shown that stearic acid, the main component of beef fat, actually lowers cholesterol.59 Margarine, on the other hand, provokes chronic high levels of cholesterol and has been linked to both heart disease and cancer.60 The new soft margarines or tub spreads, while lower in hydrogenated fats, are still produced from rancid vegetable oils and contain many additives.