Not exact matches
These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven
by federal and state grant cycles which may not mirror patient demand and may
cause fluctuations in Gilead's earnings; market share and price erosion
caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held
by wholesalers and retailers which may
cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc
finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may
cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).
Of course, I might be holding back out of fear of being invited
by Christine O'Donnell to a satanic witchy picnic on a blood - stained altar (said bloodstain most likely
caused by a diabetic performing some dark and devilish ceremonial pricking of their
finger to check their glucose levels, which obviously is demonic in nature and proof of why the healthcare reform act should be done away with so they can let such practitioners of such technological dark arts die due to lack of insulin)
Mackey persuaded a doctor to cut off his left index
finger, which throbbed with pain from nerve damage
caused by radiation treatments.
And it took some time for him to regain dexterity in his left hand after he persuaded a doctor to cut off the index
finger, which throbbed with pain from nerve damage
caused by radiation treatments.
It can be thrown either
by releasing index
finger first,
causing ball to spin a little off center, or else
by gripping ball slightly off center in the first place — which will achieve the same effect.
It can be thrown either
by releasing the index
finger first,
causing the ball to spin a little off center, or else
by gripping the ball slightly off center in the first place, which will achieve the same effect.
But a bit harder to point the
finger with Coquelin, Cazorla and Wilshere that were injuries
caused by collisions.
Jack hasn't been able to have a really good run of games but his condition at the end of last season and for England looked fantastic the fittest I've seen him for years genuinely believe his injury days could be over a lot of injuries were
caused by pins in his foot but have now been removed so
fingers crossed.
Studies conducted
by Larsson21, 22 concluded that prolonged
finger sucking
caused an anterior open bite, proclination and protrusion of the maxillary incisors, a lengthening of the upper arch and the anterior displacement of the maxilla.
A 2016 study published in Pediatric Dental Journal found that a callus on the thumb or
finger caused by sucking predicts a malocclusion — imperfect positioning of the teeth when the jaws are closed — in children.
Sores, sensitive gums
caused by teething can be relieved
by applying pressure with a clean
finger or damp washcloth.
By the fourth month, teething may
cause the baby to begin drooling, sucking on his
fingers, or chewing on objects.
It is normal that the
fingers and fists are brought to the mouth very often and with an unstoppable desire to bite to press the gums, that his drooling is more abundant than usual, produced
by the stimulation of saliva produced
by the dentition, which present an unusual irritability due to pain in the gums, cry more than necessary, have problems to sleep, refuse food due to increased pain
caused by suction, diarrhea due to excess swallowed saliva and low fever
cause of inflammation.
Continuous added pressure on a specific duct restricting complete milk flow (Most Common Reason) This can be
caused by wearing a tight underwire bra, constantly holding the breast with your hand and
fingers while feeding, or from placing a
finger between the breast and the infants nose.
Releasing the parking brake
causes the brake handle to snap back quite fast so you need to be careful not to get your
fingers hit
by it.
I got her on similac
cause i didint powant her to dehydrate and i contacted a lactation consultant she told me to leave her with formula for a few days to let my nipples get bettter and then try again so i did it was frustrating but i finally got the hang of it
by week 2 everything was great now im having another problem and it seems shes not satisfied with my milk she drinks for about 15 minutes each feeding and i can hear her swallow the milk and it even runs out of her mouth, but 30 minutes latter and sometimes less shes crying sucking her
fingers looking for my breasts so i would put her again and that
caused me to get an imbalance in my milk due to oversuply so i had to block nurse and obviosly she was hungry so now i feed her both more bm o
According to the Consumer Product Safety Commission, hand and
finger damage are the most common injuries
caused by fireworks and account for 32 percent of all injuries reported.
Ciliopathies are
caused by defects in cilia,
finger - like projections from cells that act as microscopic «antenna» to detect and respond to chemical changes or fluid flow outside the cell.
What's more, say the researchers, the cancer -
causing effects of off - target deletions mistakenly created
by the V (D) J enzyme need to be considered in designing site - specific enzymes for genome modification such as zinc -
finger nucleases, TALENS, or CRISPRs.
These images depict how the photonic sensor translates
finger movements into color changes, as the photonic crystal reacts to the change in local humidity
caused by the approach of the
finger without direct contact.
She has no eyes,
fingers or toes due to a birth defect called Fraser Syndrome that is believed to have been
caused by her grandparents» exposure to the herbicide Agent Orange during the Vietnam War.
Light -
fingered chimpanzees are changing the way subsistence farmers make a living in Africa
by causing them to grow different crops and spend more time guarding their goods.
Because Huntington's disease is
caused by a single faulty gene, it's a good candidate for zinc
finger drug research.
Studying owl monkeys and squirrel monkeys, he found that damage to a nerve, or loss of one or two
fingers caused the portion of the map that had lost its input to be overtaken
by neighbouring maps, as neurons in the affected area became responsive to other areas of skin.
May 06, 2015 In late post-surgical colon «leaks,»
finger points to microbes Post-surgical leaks that develop after a segment of the colon has been removed and stitched back together often are
caused not
by negligence or technical error but
by bacteria in the bowel that elude antibiotics, according to new evidence about this devastating complication of gastrointestinal surgery.
This is far more effective than using fat grips because it will force you to perform rowing motions optimally
by eliminating excessive momentum and range of motion, while overstretching will
cause the weight to slip out of your
fingers.
Over time, these immune reactions
by way of the antibodies can
cause major wear and tear affecting the tiny microscopic
finger like projections in the small bowel (particularly the duodenum, the first part of the small bowel) in a process called villous atrophy.
You can do this with a regular (cooked or canned) chickpea
by pinching it between your
fingers, which will
cause the outer skin to slip off, and then the two halves of the pea will naturally fall apart.
Cold weather can
cause your
fingers to shrink a bit, while heat or water retention
caused by food, medications, or illness can
cause finger swelling.
Grau provides a brief, optional introduction to the picture, hoping it
causes us «extreme suffering» and putting his
finger,
by that statement, on the exact reason a lot of us are drawn to exploitation flicks.
Infinity War was released three weeks ago and saw Thanos, the big purple dude played
by Josh Brolin, on a quest to locate all the infinity stones so he could click his
fingers causing half the universe, including your favourite superheroes, turned into fine powder.
Once again I am responding to an article on teacher shortage.What this minister fails to address is the way successive governments have contributed to denigrate and ridicule teachers over the past twenty years.Now they are blaming other factors as the
causes of teachers leaving and I do not see any
finger pointing at Ofsted who must take part of the blame for this crisis.It seems to me that ministers must come clean
by holding up their hands and admit that they are part of the problem.Teachers will continue to leave until there is a complete reversal
by a society which states that this is a noble profession and one that needs to be cherished and protected instead of being constantly attacked
by various members in the community.The time for attacking teachers is over and now we can see the real
causes for this.Good luck to all those in the teaching profession.You do a wonderful job amidst trying circumstances.I take my hat off to you.
Pressure applied to the surface of the display
by a
finger or stylus
causes the layers to touch, which completes electrical circuits and tells the device where the user is touching.
Without Lifting a
Finger, Change Amazon Book to Popular ePub * In contrast to Amazon Kindle's proprietary format, ePub format would be more popular or is the most needed and supped
by most devices, but most of current devices like iPad or some android phone are not quite sufficient to support Amazon MOBI format, this could
cause headaches for those who need to read Amazon books on iOS devices, but now, this program gives you full ability to turn Amazon books to popular ePub format with easy.
Maybe it's my old, fat, shaking
fingers or maybe my device is faulty, but I have a problem with the user interface aggravated
by my frequent need for the dictionary: Oftentimes trying to highlight a word either selects multiple words or, when the word is near the edge of the screen,
causes a page turn.
this has evolved into major research ------ as in many people have their
fingers into the pie ---- a huge pie ---- billions ---- and all of these will be out of work if the truth was to come out ---- many are blind to the truth and do not want to hear it ------ for it will mean they are out of a job ------ Note the Climate change people do not want to use Satellite data ------ it is not corrected ---- but want to use the ground based monitors ---- which are corrected for location
caused errors ----
by humans ------ with their lively hood at risk this adjusted Data is then feed to other researches ---- who take this data as fact --------
Several times the report mentioned the stress on the system
caused by increased penetration of wind and solar energy, a controversial topic, which has seen
fingers pointed at all number of technologies, policymakers and freak weather events.
The research, which was led
by Hanqin Tian of Auburn University with a long list of 22 co-authors, points the
finger at phenomena like animal agriculture, rice cultivation and waste disposal as key features of climate change that don't get much attention, but that overall are
causing the Earth to heat up even more than it would otherwise.
They can however both be held liable on Clements material contribution: the estate can show the loss was
caused by a tort, both were sufficiently negligent, and can only defeat causation through a point the
finger approach.
Pain in
fingers caused by working for long hours using a standard...