Sentences with phrase «caused by immune cells»

Some have proposed that age - associated inflammation is caused by accumulating wear and tear on our immune cells, while others have suggested that it is caused by immune cells dealing with chronic viral infections.

Multiple sclerosis (MS) is caused by immune cells that activate a cascade of chemicals in the brain, attacking and degrading the insulation that keeps neuronal signals moving.

Not exact matches

Beta - carotene has been found to reduce cell damage caused by free radicals, and improves immune function by enhancing cell mediated immune responses.

Autoimmunity is commonly caused by bacterial infections or overgrowth in the small intestine, in which partially digested food compounds are incorporated into bacterial cell walls and then the immune system, reacting to the bacteria, forms antibodies that also recognize food compounds, some of which might cross-react with human counterparts.

In the present study, the researchers have discovered a reason for reduced fertility in people with autoimmune polyendocrine syndrome type 1 (APS1), which increases the risk of developing autoimmune disease (caused by the immune system attacking and damaging healthy cells) and which is often used as a model for autoimmune disease in general.

«Chronic inflammation of the intestine is thought to be caused by abnormal interactions between gut microbes, intestinal epithelial cells and the immune system, but so far it has been impossible to determine how each of these factors contribute to the development of intestinal bowel disease,» said Hyun Jung Kim, Ph.D., former Wyss Technology Development Fellow and first author on the study, speaking about the limitations of conventional in vitro and animal models of bacterial overgrowth and inflammation of the intestines.

Neutrophils are one of the most common types of immune cells and known to engulf microorganisms, but they are not normally associated with peripheral nerve damage, such as that caused by diabetes or trauma.

The most common type of skin lymphoma is caused by the fact that specific immune cells — CD4 - T - lymphocyttes — turn into cancer cells.

Although the group didn't identify the toxin's target, it probably causes cells to die from within by overstimulating the immune system, says immunologist Harry Hill of the University of Utah.

Published in the journal Frontiers in Neuroscience, the researchers have assembled strong evidence that the neurological decline common to these diseases is caused by «auto - inflammation», where the body's own immune system develops a persistent inflammatory response and causes brain cells to die.

These chemicals, called cytokines, drive the inflammation in the brain, attracting more immune cells, and causing the debilitating disease marked by loss of neurological function.

«Inflammatory arthritis is caused when immune cells are recruited from the blood into the joint in a highly regulated process controlled by chemoattractants and adhesion receptors,» says Andrew Luster, MD, PhD, chief of the MGH Division of Rheumatology, Allergy and Immunology, director of the CIID and senior author of the report.

Researchers from the Gladstone Institutes have revealed that HIV does not cause AIDS by the virus's direct effect on the host's immune cells, but rather through the cells» lethal influence on one another.

Since a primary function of the dendritic cells is to present an antigen to T - cells, to activate the T - cells and begin the immune response, the researchers suspected that T - cell activation in the heart tissue, and perhaps heart - tissue injury caused by T - cells, might be central to the pathological heart enlargement that is called remodeling.

Affecting the central nervous system, it causes neonatal meningitis by multiplying in immune cells, such as macrophages, and then disseminating into the bloodstream to subsequently invade the blood - brain barrier.

In laboratory studies, daratumumab caused the targeted killing of CD38 - carrying tumor cells by several distinct and potent mechanisms, including some that involve the immune system.

However, the use of NF - kB inhibitors in treating cancer is complicated by severe side effects related to immunosuppression caused by indiscriminate inhibition of NF - kB in normal immune cells.

The lingering of the fetal DNA, research suggests, may be a mixed blessing for a mom: The cells may benefit the mother's health — by promoting tissue repair and improving the immune system — but may also cause adverse effects, such as autoimmune reactions.

She previously showed that when blood leaks into the brain, fibrinogen causes inflammation by acting in brain immune cells, which can lead to brain damage.

Researchers developed a new type of cell transplantation to treat mice mimicking a rare lung disease that one day could be used to treat this and other human lung diseases caused by dysfunctional immune cells.

Hepatitis researchers have long thought that immune cells sent by the body to attack virus - infected cells in the liver cause the acute liver injury associated with hepatitis A virus (HAV) and other hepatitis viruses.

In many cases the damage is caused by a particular group of immune cells called effector memory T - cells.

«You don't want to just turn down methylation globally, which would result in over-activation of all genes in the cell, but demethylating some of these gene promoter regions selectively could revive an immune system muted by cancer - causing viruses,» Kuss - Duerkop says.

Most of the time when the heart is injured, these beneficial immune cells are supplanted by immune cells from the bone marrow, which are spurred to converge in the heart and cause inflammation that leads to further damage.

«New potential cause for Alzheimer's: Arginine deprivation caused by overconsumption by immune cells.»

After all, that would seem to offer a neat explanation for how HIV causes the collapse of the immune system by suppressing T cells.

THE DEMENTIA associated with Alzheimer's disease may be caused by toxins that the body's own immune cells produce.

Researchers have found that pregnancy - related stress hormones shield the fetus by causing attacking immune system cells, or T cells, to self - destruct.

Building on that work, the current paper looked at a less lethal strain, the H1N1 «swine flu,» that does not infect neurons, but which, the researchers showed, still caused inflammation in the brain via inflammatory chemicals or cytokines released by immune cells involved in fighting the infection.

Now, researchers have found that a very small subset of anti-viral immune cells, transplanted along with a donor's blood stem cells, could be enough to fight and even prevent the disease caused by CMV, in research conducted in mice and published Jan 16th in the Journal of Immunology.

The patients without diabetes produced autoantibodies that completely impaired the activity of a subtype of interferon known as interferon - alpha, which is produced by the immune cells and may cause inflammation.

«Zika virus may cause microcephaly by hijacking human immune molecule: Fetal brain model provides first clues on how Zika virus blunts brain development; blocking mechanism reduces cell damage.»

In animal studies, exosomes secreted by immune cells during environmental enrichment caused cells in the brain to start myelin repair.

Vaccines work by exposing the body to the disease - causing agent or a fragment of it, which primes the immune system to produce a flood of antibodies that stick to the infecting organism and block it from entering cells.

Dr. Siqueira said she and her colleagues are now investigating whether the problem was the result of an auto - immune disorder sparked by one of the viruses that caused the immune system to attack nerve cells, similar to what occurs in Zika patients who develop Guillain - Barré Syndrome.

A TROPICAL disease that can fatally damage the heart may take hold in the human body by causing important immune system cells to commit suicide, according to a Brazilian research team.

Microbes that cause diseases like HIV, malaria, and hepatitis C exploit and often activate the same checkpoint pathways — cell surface receptors such as CTLA4 and PD - 1 — to slow immune cells and prevent their elimination by the host.

The researchers studied two unrelated sets of siblings with similar immune problems and determined their symptoms were likely caused by a lack of CD70, a protein found on the surface of several types of immune cells.

Led by CU - Boulder Assistant Research Professor Peter Grace and Distinguished Professor Linda Watkins, the study showed that just a few days of morphine treatment caused chronic pain that went on for several months by exacerbating the release of pain signals from specific immune cells in the spinal cord.

CAR T - cells can cause adverse reactions by overstimulating the immune system, particularly in adults.

Although the study didn't address how the beneficial bacteria swallowed by the volunteers could have affected their respiratory tract, Gebbers and Glück hypothesize that ingesting Lactobacillus GG stimulates intestinal immune cells and causes them to migrate to other parts of the body.

To get to the bottom of this question, researchers in the Perelman School of Medicine at the University of Pennsylvania engineered mice in which the damage caused by a mutant human TDP - 43 protein could be reversed by one type of brain immune cell.

Too large a dose can cause congestive heart failure, among other side effects, while a small dose may be overwhelmed by immune cells, which consider doxorubicin a foreign invader.

Breaches in these layers, which can be caused by physical trauma or some sexually transmitted diseases, allow HIV to bypass the protective surface to access immune cells that can be infected by HIV.

Most are destroyed by the immune system or their own programmed cell death mechanisms, but enough linger for the long term for their growing presence to be one of the contributing causes of the aging process.

By studying the banana lectin molecule (top left) and what made it bind to both viruses and immune system cells (bottom left), the team was able to figure out how to change the way cells bind it, to make a new version (top right) that still binds viruses but doesn't cause inflammation (bottom right).

In a typical immune response, for instance, inflammatory proteins called cytokines will be released by immune cells at a site of inflammation and then other immune cells will use these cytokines like a trail of breadcrumbs to home in on the site of infection and destroy the pathogens that are causing it.

Another technique - one used by the herpes simplex virus which causes cold sores - is to hide from the immune system in nerve cells called neurones.

Some not - yet - identified molecule, or combination of molecules, such as proteins, fats, or sugars, made by bacteria cause the immune system to produce T helper 17 cells (Th17), which trigger a surge in inflammation as part of the response to a pathogenic strain.

In the paper, the team outlined a mechanism by which stressed beta cells are actually causing the immune response that leads to their own demise.