Sentences with phrase «caused changes in the expression»

The researchers also showed that regular feeding with the Lactobacillus strain caused changes in the expression of receptors for the neurotransmitter GABA in the mouse brain, which is the first time that it has been demonstrated that potential probiotics have a direct effect on brain chemistry in normal situations.

Not exact matches

In the new research, the UB scientists found they could reverse those social deficits with a very low dose of romidepsin, which, they found, restores gene expression and function using an epigenetic mechanism, where gene changes are caused by influences other than DNA sequences.

The Epstein - Barr virus, which infects some 90 % of Americans, may cause changes in gene expression that dramatically increase a person's chance of getting lupus and six other autoimmune disorders, a new study by Harley, now a rheumatologist at the Cincinnati Children's Hospital Medical Center in Ohio, and colleagues shows.

A growing body of evidence suggests that environmental stresses can cause changes in gene expression that are transmitted from parents to their offspring, making «epigenetics» a hot topic.

The researchers found that the blond hair commonly seen in Northern Europeans is caused by a single change in the DNA that regulates the expression of a gene that encodes a protein called KITLG, also known as stem cell factor.

The Epstein - Barr virus (EBV), which infects some 90 % of Americans, may cause changes in gene expression that dramatically increase a person's chance of getting lupus and six other autoimmune disorders, a new study by Harley and colleagues shows.

Further studies discovered that the BRAF protein could turn on many itch genes, and they showed similar changes of gene expression in mice with chronic itch induced by dry skin and in mice with allergic contact dermatitis, two of the skin conditions that frequently cause people to scratch incessantly.

Douglas Thomas, associate professor of medicinal chemistry and pharmacognosy at UIC, and co-workers discovered that nitric oxide plays an important role in epigenetics — heritable alterations in gene expression caused by mechanisms other than changes in DNA sequence.

Using clinical, genetic, and gene expression data as filters to distinguish genes whose copy number alteration causes cancer from those for whom copy number changes are incidental, the team whittled down their list from 14,000 to a more manageable number, each of which they systematically tested using genetic experiments in animals.

«The other thing I think is interesting is that there are not that many cases where people have been able to use gene expression, absent any genetics, to zoom in so precisely on a genetic change that causes an obvious trait,» he added.

Analysis showed that incremental changes in the number of repeats caused non-harmful variations in the expression of the genes regulated by Ssn6.

The first clues that assisted reproduction was causing changes in methylation and gene expression came from animal cloning studies back in 2001, Sapienza says.

Ultimately, these signals change the expression of genes in the cell nucleus, causing the cell to grow abnormally.

Hutchinson - Gilford progeria is caused by a spontaneous mutation during conception in a gene called LMNA, which encodes a protein called prelamin A. Progeria patients experience a buildup of an abnormal version of prelamin A in their cells that, among other changes, distorts the nucleus and alters gene expression.

One of the mechanisms driving alterations in gene expression is epigenetic change, where the female is able to change her offspring's genome to cause certain genes to be expressed differently.

The change in the environment — the tumor and its surroundings — causes the abnormal expression of these proteins.

DNA methylation and the change in chromatin structures caused by histone modification are both linked to modification of gene expression.

«Our hypothesis was, if a disease is characterized by certain changes in gene expression and if a drug causes the reverse changes, then that drug could have a therapeutic effect on the disease,» he says.

Using this approach, these investigators found that nodes (genes) with high connectivity tend to have lower levels of change in expression than peripheral nodes, consistent with the notion that disease ‐ causing genes are typically not central hubs in a molecular module.

Based on analyses of over 600 drug and breast cancer cell pairings, researchers showed that, for some cells, drug exposure can cause significant changes in gene expression — indicating the successful action of a drug on its target — without affecting cell growth or survival.

In these cases, drug exposure caused significant changes in tumor cells» gene expression profile but had no lasting physical effecIn these cases, drug exposure caused significant changes in tumor cells» gene expression profile but had no lasting physical effecin tumor cells» gene expression profile but had no lasting physical effect.

Epigenetics is the study of changes in organisms caused by modifying gene expression — by alcohol, for example — rather than alteration of the genetic code itself.

Because PMI dependent expression changes are largely tissue - specific, they could confound tissue differential gene expression since the observed effects could be caused by differential response to PMI rather than by differences in tissue biology.

So what kind of harm can the changes in gene expression resulting from (epi) mutations cause?

We propose that the age - related decline in the regenerative behavior of glial cells is caused by loss of cell - to - cell communication and changes in the internal gene expression of glia cells.

Makarevitch I, Harris C * (2010) Aneuploidy causes tissue - specific qualitative changes in global gene expression patterns in maize.

Bruneau's team is now researching the precise changes in gene expression and protein levels caused by a mutation in TBX5.

If left unchecked, these changes in gene expression cause the heart to become enlarged, inflamed, and full of scar tissue.

We are also examining how gene expression changes caused by chromatin modifier mutations interact with other commonly mutated pathways in urothelial cancers such as RTK - RAS - RAF and PI3K - AKT - MTOR to influence therapeutic response and resistance.

Changes in an epigenetic mechanism that turns expression of genes on and off may be as important as genetic alterations in causing pediatric acute lymphoblastic leukemia (ALL), according to a study led by scientists at St. Jude Children's Research Hospital and published in the June 10 online edition of the Journal of Clinical Investigation.

While a sense of obligation to share science, enact change in academia or advocate for a cause are reasons some scientist bloggers give for communicating online, these fall much further down the list of motivations, while popularizing science and self - expression motivations dominate.

Fascinating research from the lab of Mark Zylka, PhD, director of the UNC Neuroscience Center, suggests that chemicals designed to protect crops can cause gene expression changes in mouse brain cells.

Epigenetics studies the changes in a body caused by the modification of gene expression, despite inheriting the same genetic code.

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