What's more exciting is mice studies show that transplanting bacteria from thin humans into obese mice
causes the obese mice to lose weight.
Not exact matches
Injections of leptin in
obese mutant
mice cause them to reduce food intake and lose weight (and these injections work even if tiny doses are delivered directly to the hypothalamus).
In our previous study we found that a high fat diet containing comparable amounts of soybean oil to what Americans are currently consuming
caused mice to become
obese, diabetic and insulin resistant and to have large lipid droplets and hepatocyte ballooning in their livers.
The scientists found that
obese mice had more harmful bacteria in their guts compared to lean
mice, which
caused inflammation throughout their bodies, leading to very rapid joint deterioration.
For some years an asthma drug called amlexanox has been studied for its ability to inhibit TBK1, and a previous experiment showed that when administered to
obese mice, it
caused weight loss and increased the animals» sensitivity to insulin, helping improve their diabetes and fatty liver disease.
Normal
mice had a gene which
caused fat cells to secrete leptin, but the mutated
obese mice lacked that gene.
To explore whether this was a
cause of obesity or the effect of it, another research team gave
mice the bacteria from sets of twins where one was
obese and the other was lean.
The healthy
mice developed low - grade intestinal inflammation and a metabolic disorder that
caused them to eat more, becoming
obese, hyperglycemic, and resistant to insulin.