Sentences with phrase «causes cell cycle»

They further show that this diterpine downregulates HMG CoA reductase offering support to the concept that mevalonate deprivation causes cell cycle arrest at the G1 phase leading to apoptotic death of the prostate carcinoma cells.

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These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

As revealed through another series of coin - cell battery tests, 4.7 volts caused rapid decomposition of the electrolytes and poor cycling — the higher power comes at a price.

Malaria parasites, which are transmitted through the bite of an infected mosquito, cause the most destruction during the part of their life cycle when they dwell in red blood cells circulating through the body.

In theory, if a single mutation popped up that caused immature neurons to undergo just one extra cycle of cell division, that could double the final size of the cortex.

Endometriosis is caused by uterus lining (endometrium) cells moving elsewhere in the body where they can compress nerves and bleed in time with a woman's menstrual cycle.

Endometriosis is caused by uterus cells moving elsewhere in the body and bleeding in time with a woman's menstrual cycle.

This research, published in the March 3 edition of PLOS ONE, provides the first evidence that urinary BPA levels may help predict prostate cancer and that disruption of a cell duplication cycle through exposure to low - dose BPA may cause cancer development in the prostate.

This activation causes additional stress which keeps the macrophages «turned on» in a cycle that amplifies and further damages the cells and surrounding tissues.

Prof. Umeda found that inhibiting CDKs even with the absence of DNA damage would cause the Rep - MYB3R accumulation seen with DNA damage and stall the cell cycle before the M phase transition.

Firstly, salt stress causes a delay in cell division, leading to synchronization of cell cycles; secondly, survival probability depends on the individual bacterial cell's position in the cell cycle at the time of the second exposure.

As revealed in the Nature paper, this repetitive cycle of abortive infection, cell death, inflammation and recruitment of additional CD4 T cells to the infection «hot zone» ultimately destroys the immune system and causes AIDS.

Some of the common genetic alterations identified in the study were gains and losses in chromosome 8, as well as cell proliferation and cell - cycle progression — key mechanisms of cancer caused by genetic alterations — linked to the genes AURKA, AURKB and FOXM1.

«The cancer stem cells actively regrow and respond to the induced damage or apoptosis (cell death) caused by chemotherapy in between the different cycles, similar to how normal tissue stem cells respond to wound - induced damages.»

Hall and Rosbash then discovered a protein, named PER, that was made by the period gene, and figured out how it worked through a feedback mechanism — its own expression in the cell would cause PER to build up in the nucleus and would eventually effectively shut off the period gene, allowing it to cycle on and off on a daily schedule.

In S. cerevisiae, approximately 900 genes out of 5800 are cell lethals, and an additional 900 act to stop cell cycle processes or cause impairment of growth on specific media (Burns et al., 1994).

Studies in the Orr - Weaver lab have illuminated fundamental aspects of this process, known as the cell cycle, and shed new light on a broad range of diseases caused by breakdowns in cell division, including cancer and certain birth defects.

Psoriasis is an autoimmune disease that causes skin cells to go through the life cycle more quickly than normal.

The combination of grape extract and physical activity offers more protection than physical activity alone 06.03.2018 Betaine forces fat cells to eat themselves 17.02.2018 Nine easy ways to lose body fat 13.02.2018 Sewage water during bodybuilding competitions full of DNP 04.02.2018 «Safe» DNP cycle, fatal outcome 27.01.2018 Paleo diet makes fat cells lazy (and if you're trying to lose weight, that's exactly what you want) 21.01.2018 Legumes facilitate weight maintenance and fat loss 20.01.2018 More sleep = less sugars in your diet 17.01.2018 Low intensity cardio before breakfast burns more fat if you take some L - phenylalanine 29.12.2017 Slimming goes better with a couple of tablespoons of chia daily 23.12.2017 Better weight loss results with intermittent low - calorie diet 01.12.2017 Circuit training with light weights causes just as much fat loss as classic cardio training 23.11.2017 Allulose, the low - calorie carb that boosts fat burning 19.11.2017 Alpha - linolenic acid - diacylglycerol steps up fat burning 16.11.2017 People who use light products are fatter 30.10.2017 This is what happens if you eat 14 g goji berries every day 17.10.2017 Soft drink ruins slimming effect of high - protein diet 14.09.2017 When children take 8 g inulin daily their fat layers stop growing 09.08.2017 Enhanced fat burning through green and white tea - brown fat cells play key role 13.07.2017 Short interval training between meals keeps a slimming diet on course 15.06.2017 Exercising before breakfast trains your fat tissues to break themselves down 01.06.2017 Lose weight without noticing it: drink water when you're thirsty 20.05.2017 Animal study: plant - based proteins with bad amino acid profile make you fatter 14.05.2017 Weight loss diet while physically inactive speeds up loss of muscle mass 12.05.2017 Lose weight faster than you'd believe possible: skip breakfast and jog for an hour 09.05.2017 Skip breakfast - a slimming trick that works 03.05.2017 Eating whole grain products instead of refined ones saves you a hundred kilocalories a day 01.05.2017 Another fat browner: curcumin 27.04.2017 Two cups of green tea daily results in more brown fat 25.04.2017 Boost your flavonoid intake and lower your fat percentage 21.04.2017 Not a breakfast eater?

When this happens for a period of time, the cells start to become resistant to the presence of insulin, causing a vicious cycle.

Saturated fat causes more of those toxic breakdown products and mitochondrial dysfunction, and increases oxidative stress, free radicals, and inflammation, establishing a vicious cycle of events in which saturated fat - induced free radicals cause dysfunction in the little power plants within our muscle cells, which causes an increase in free radical production and the impairment of insulin signaling.

For example, Dr. Greger discusses a» vicious cycle of events in which saturated fat induced free radicals causes dysfunction in the little powerplants within our muscle cells, which causes an increase in free production and impairment of insulin signaling.»

Abnormal Krebs cycle and / or oxidative phosphorylation cause (s) not only glucose hypometabolism but also the increased generation of reactive oxygen species (ROS), oxidative damage, and programmed cell death such as apoptosis.

High levels of estrogen also causes more fatty tissue growth, and your fat cells in turn make more estrogen; so it's a vicious cycle.

This starts a chain reaction of excess toxins and acids which cause irritation of the small intestine cells damaging them and causing food absorption issues which only helps to continue the cycle.

Now insulin and leptin are not staying high for a few hours a day, but staying high throughout the entire day... and night, whether one eats or not... Causing more and more insulin and leptin resistance in a vicious cycle until, at least for insulin, the islet cells start burning out... lowering insulin but further raising glucose... and now we are into full - blown diabetes.

Cyclic Hematopoiesis with color dilution AP3B1 ELANE mutation causing cycles of low wbc (white blood cell production) in collies predispose these dogs to secondary bacterial infections and amyloidosis, and most die less then one year of age.

Every heat cycle, there's a natural reduction of white cells from the uterus to allow for safe sperm passage, causing a lapse in protection that can decrease the ability to fight infection.

We had to ride south on Avenue Road, keeping as close to the curb as possible on one of the busiest streets in town in the middle of rush hour, wondering what kind of governments hypocritically promote cycling and then neglect to provide any decent routes; that refuse to demand sideguards on trucks like they do in the UK; that refuse to enforce the few rules about parking or driving in bike lanes; and that refuse to ban cell phone use while driving when 80 % of accidents are caused by inattention of drivers.