Sentences with phrase «causes cellular senescence»
The breast cancer drug palbociclib arrests cells in G1 phase by CDK4 / 6 inhibition, but also causes cellular senescence.
http://emboj.embopress.org/ Not exact matches
P16: P16 is perhaps best known as an indicator of cellular senescence, a part of the mechanisms that cause damaged cells or those at the Hayflick limit to become senescent or self - destruct.
An obvious question is how cellular senescence caused by deficient DNA repair finally affects the aging of a living organism.
The damage that it will repair is the one that is causal in senenscence of DNA pathway (such x-ray radiation causing senescence) and oncogenic activated senescence; but not of the type of replicative senescence (that's the domain of telomeres / telomerase / sub-telomeres and epigenetics) and cellular replication / proliferation.
It reveals that targeted treatments for acute promyelocytic leukaemia, a rare form of blood cancer, cause a cascade of molecular events leading to cellular senescence and recovery.