Sentences with phrase «causes changes in our cell»

This bank of living tumour cells allowed the team to study not only the genetics of the cells, but also how genetic mutations in the mitochondria — which drive energy production in the cell — caused changes in the cell's metabolism.

And some metabolic mutations, which themselves can promote cancer - causing changes in the cell, will be more successful if they're followed by mutations in tyrosine kinases or transcription factors that stimulate cell growth.

In Nasonia, non-coding cis - regulatory evolution at the ws1 locus causes changes in both cell size and cell number.

In addition to the above mood and anxiety roller coaster, sugar causes changes in our cell membranes, in our arteries, our immune systems, our hormones, and our gut, as I discuss here.

In addition to the above mentioned mood and anxiety rollercoaster, sugar causes changes in our cell membranes, in our arteries, our immune systems, our hormones, and our gut.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Sometimes mutations in DNA can cause changes in the way a cell behaves, as orchestrated by God.

It occurs when some of the red blood cells change into a «sickle» shape and cause a buildup of red blood cells in small blood vessels.

[Robert Siman et al, Serum SNTF Increases in Concussed Professional Ice Hockey Players and Relates to the Severity of Post Concussion Symptoms] A strong blow to the head causes chemical changes within nerve cells that damage their structural proteins.

The bacteria Helicobacter, believed to be a cause of stomach cancer, has been shown to trigger potentially cancer - inducing epigenetic changes in gut cells.

Using human fetal «mini-brains» grown in 3 - D cultures, scientists determined that a specific protein produced by the Zika virus changes the properties of neural stem cells in the developing brain of an infected fetus, potentially causing microcephaly in newborns (Ki - Jun Yoon, abstract 103.06, see attached summary).

In cancer cells, the protein networks that control the behavior are changed in such a way as to cause the cells to lose control and break away — a mutated skin cell, for instance, might then migrate into the bloodstreaIn cancer cells, the protein networks that control the behavior are changed in such a way as to cause the cells to lose control and break away — a mutated skin cell, for instance, might then migrate into the bloodstreain such a way as to cause the cells to lose control and break away — a mutated skin cell, for instance, might then migrate into the bloodstream.

«We also found that the bits of gluten that were presented to the T - cells have some changes caused by an enzyme in the body — transglutaminase 2,» says Sollid.

Immunotherapy caused an increase in peanut - specific T cells, accompanied by a change in the distribution of T - cell subtypes over time.

Stories on a possible cause for severe morning sickness and how a mother mouse's care for her pups might trigger changes to the genomes in their brain cells

«Disturbances to these processes may cause neuronal stem cells to develop into different types of cells or may cause neurons to migrate to different locations in the brain, changing neuronal circuitry and potentially leading to behavioral disorders like schizophrenia.»

He and colleagues have determined what gives cholera bacteria their curved shape and whether it matters (a polymer protein, and it does matter; the curve makes it easier for cholera to cause disease), how different wavelengths of light affect movement of photosynthetic bacteria (red and green wavelengths encourage movement; blue light stops the microbes in their tracks), how bacteria coordinate cell division machinery and how photosynthetic bacteria's growth changes in light and dark.

Further investigation revealed that loss of surrounding cells causes multiple changes in cell communication, which impairs bone cells» ability to multiply and increase in size.

Vogelstein, Kenneth Kinzler, and other colleagues found a minor change in the APC gene, which normally holds cell growth in check and can cause colon cancers when mutated.

These atypical AMPA receptors were missing a key subunit, called GluA2, that caused a change in shape and allowed calcium ions to enter the cell.

«In the past, we've thought the resistance was caused by genetic changes in tumor cellIn the past, we've thought the resistance was caused by genetic changes in tumor cellin tumor cells.

Metabolic changes, caused by a poor diet and a sedentary lifestyle, trigger's the genetic reprogramming of cells in the body and joints.

The researchers found that the blond hair commonly seen in Northern Europeans is caused by a single change in the DNA that regulates the expression of a gene that encodes a protein called KITLG, also known as stem cell factor.

By measuring changes in the levels of proteins that control each cell death program and by observing the cells» physical changes, the team saw clearly that cocaine causes neuronal cell death through out - of - control autophagy.

The body relies on cells to process and store energy, and changes in genes that regulate these functions can cause an imbalance that leads to excessive energy storage and weight gain.

Findings by Cincinnati Cancer Center researchers show that levels of bisphenol A (BPA) in men's urine could be a marker of prostate cancer and that low levels of BPA exposure can cause cellular changes in both non-malignant and malignant prostate cells.

The researchers found that Myc activates cancer - like changes in cell metabolism, causing a sudden fall in ATP concentration inside the cells.

Low energy electrons are ubiquitous and are known to play important role in variety of phenomena relevant to astrochemistry (where they participate in synthesis of new molecules), in radiation biology (where they cause chemical changes in living cell, plasma chemistry), atmospheric chemistry, radioactive waste management and nanolithography — to name but a few.

But thin - film solar cells hold the promise of harnessing the sun's power in an efficient and sustainable way — and displacing the burning of fossilized sunlight for energy that is contributing climate change — causing carbon dioxide to the atmosphere.

After tracking the injected cells in the mice for more than 10 days using bioluminescence and fluorodeoxyglucose (FDG)- positron emission tomography (PET) imaging, they found that the injection of the senescent cells into the knee region caused leg pain, impaired mobility and characteristics of osteoarthritis, including damage to surrounding cartilage, X-ray changes, increased pain and impaired function.

Stress can cause changes in the function of the immune system, including reducing the number of natural killer cells that are known to battle cancer.

With this type of cancer, the genes in the white blood cells affected change slightly, causing two chromosomes to cross.

Ozone treatment caused no changes in the PLGA and no loss of function, with cells still able to grow on the polymer scaffold, as they would in treatments.

Phase imaging is a technique that translates the changes in the phase of light caused by cells and their organelles into refractive index maps of the cells themselves.

When two copies of the altered hemoglobin gene are present, they cause the shape of the hemoglobin to change so much that the «sickled» blood cells don't flow freely in the blood vessels, causing excruciating pain.

Ciliopathies are caused by defects in cilia, finger - like projections from cells that act as microscopic «antenna» to detect and respond to chemical changes or fluid flow outside the cell.

Although the blood disorder sickle - cell anemia was first described for medical science early in the 20th century, it was not until 1956 that researchers pinpointed its cause: a single change in a nucleotide in the gene that codes for the oxygen - carrying molecule hemoglobin.

The structure and composition of the erionite from both regions is practically identical, and samples from each place cause mesothelioma - associated changes and inflammation in cell culture and mouse lungs.

Ultimately, these signals change the expression of genes in the cell nucleus, causing the cell to grow abnormally.

It is believed to result from a combination of genetics and environmental factors such as irritants and allergens that drive T lymphocytes to produce factors that cause abnormal changes in keratinocytes, the predominant cell type in the outermost layer of skin, as well as changes in other cells in the underlying dermis.

The results show that enhancer transcription causes long - term epigenetic changes in cells.

Additional micro-patterning of the substrate changes the cytoskeleton in the cell and the shape of the nucleus, which cause the genes in the cell to change.

In recent years, her group has been probing whether estrogen protects nerve cells against age - related changes that cause memory loss.

Hutchinson - Gilford progeria is caused by a spontaneous mutation during conception in a gene called LMNA, which encodes a protein called prelamin A. Progeria patients experience a buildup of an abnormal version of prelamin A in their cells that, among other changes, distorts the nucleus and alters gene expression.

Now, researchers report that they've used computers to help them target a region of the virus that rarely changes, and they've designed a small protein that renders the virus unable to infect cells and cause disease, at least in mice.

Using a CRISPR - dCas9 epigenetic editing tool, the researchers methylated different genes in healthy breast cells and found that those changes were sufficient to cause the cells to undergo «hyperproliferation» — abnormally rapid cell division which is an early stage of tumour initiation.

Anthracycline drugs, such as doxorubicin, are known to cause heart failure because they cause changes in the DNA structure of the heart muscle cells, leading to irreversible cardiac damage.

The Purkinje cells, a class of neurons located in this region, are a major site of information integration that regulate changes in neural connections caused by varying factors such as behavior, environment, and emotions.

Given the widespread use of the HeLa cell line, Lars Steinmetz and his colleagues at EMBL decided that conducting an extensive analysis of its genome could illustrate the changes caused by cancer — and also help researchers compare versions of the cell line that have evolved over decades of growth in labs around the world.

Their activation of innate immune signaling caused epigenetic changes that were absolutely necessary for the transformation of somatic cells into iPSCs,» explained Cooke, who holds the Joseph C. «Rusty» Walter and Carole Walter Looke Presidential Distinguished Chair in Cardiovascular Disease Research.