Sentences with phrase «causes death of cells»

These pathologies fall broadly into four categories: coagulopathy, where abnormal blood clotting is caused; haemorrhaging, where bleeding occurs; neurotoxicity, which damages the nervous system causing paralysis, and cytotoxicity, where the bite causes death of cells and destruction of tissue.

They observed that the fly was born alive but without wings; so the removal of this molecule caused the death of all cell precursors of this tissue (if histone 1 is removed from the entire fly, the embryo dies).

Not exact matches

For one, it would give them three specific biological markers to hone in on: The buildup of beta amyloid and tau proteins, which cause brain plaques associated with Alzheimer's, and brain nerve cell death.

Adult stem - cells are now being used to grow new body - parts that can be implanted with no risk of rejection, the latter being the single largest cause of organ rejection and subsequent death.

In May 2007 Newsweek Healthcarried an article stating that heart cells can remain alive for several hours even without oxygen, and that it is the sudden resumption of the oxygen supply, as attempts are made to resuscitate the individual in hospital, that causes apoptosis, killing the cells and causing death.

2) scientifically death is the result (natural death) of the imperfect reproduction of cells within our bodies causing organ failure over time.

It's sometimes said that nutritional yeast contains compounds similar to monosodium glutamate (MSG), an excitotoxin that overexcites your cells to the point of damage or death, causing brain damage.

Clamping the cord, especially at an early stage, may also cause the extra blood trapped within the placenta to be forced back through the placenta into the mothers blood supply with the third stage contractions.32 33 This feto - maternal haemorrhage (FMH) increases the chance of future blood group incompatibility problems, which occur when the current baby's blood enters the mother's blood stream, causing an immune reaction which can be reactivated in a subsequent pregnancy, destroying the baby's blood cells and causing anaemia or even death.

In a study published in 2006, he and other Johns Hopkins researchers tested two compounds similar to CGP3466B to see if they would block GAPDH from triggering cell death under the types of highly stressful conditions that would normally cause apoptosis.

Disease or an injury to the retina also can cause the loss of protective proteins in the cells, resulting in additional cell death.

At the same time, researchers have found that much smaller protein clusters called oligomers — made of only a few copies of these proteins — can be highly toxic to motor neuron - like cells grown in the lab and thus are more likely to be the chief causes of brain - cell death in these diseases.

The disease is caused by a genetic mutation that leads to abnormal clumps of protein in the brain, eventually resulting in the atrophy and death of nerve cells.

«For this reason, we decided to combine vitamin C with a PARP inhibitor, a drug type known to cause cancer cell death by blocking the repair of DNA damage, and already approved for treating certain patients with ovarian cancer.»

DMNT inhibitors, such as 5 - azacytidine and decitabine, boost the interactions of PARP inhibitors to block these proteins even further, causing cancer cell death, the researchers found.

By contrast, in the case of a prion infection the pathogenic prion protein interacts with the globular part and the tail causes cell death — this is the hypothesis put forward by the researchers.

Scientists have known for 20 years that SMN is necessary in every cell of the body, since disrupting the gene in a mouse causes early embryonic death, before muscle or nerve cells form.

Death of these cells in the PPN is believed to be the cause of some of the symptoms of Parkinson's disease, such as problems with attention, walking and posture.

The activation of the YAP protein induces uncontrolled cell growth and inhibits cell death, causing malignancies.

Neurodegenerative diseases are caused by the death of neurons and other cells in the brain, with different diseases affecting different regions of the brain.

Adding the dye earlier caused a 60 % decrease in cell death; adding it later reversed aggregation and prevented some damaging effects, like a loss of energy - producing ATP.

There are implications for human health in the research appearing online in Aging Cell: heart disease is the leading cause of death in the U.S., claiming nearly 600,000 lives per year.

The disease is progressive and degenerative, wherein the death of brain cells causes an array of motor and non-motor symptoms, most recognizably tremor, rigidity, slow movement and unstable posture.

Death and dysfunction of these cells cause vision loss in conditions like glaucoma and multiple sclerosis.

Lung cancer is the most common cause of cancer - related death worldwide and lung squamous cell carcinomas (SCC) account for 20 - 30 % of all NSCLC.

«Although free - floating viruses establish the initial infection, it is the subsequent cell - to - cell spread of HIV that causes massive CD4 T cell death,» says co-first author Nicole Galloway, PhD, a post-doctoral fellow at the Gladstone Institute of Virology and Immunology.

This would then use the protein to recognise a foreign or tumour cell, attach to it and release the toxin in a high local concentration, which would cause the death of the tumour cell.

Anti-cancer drugs called mTOR inhibitors slow the growth of cancer cells but show limited ability to cause cancer cell death.

The primary cause of death from breast cancer is the spread of tumor cells from the breast to other organs in the body.

The researchers conducted genetic tests and found that many of the tumor cells had a mutation in a gene called PPM1D, which causes cells to proliferate and avoid natural death.

Only when this process accelerates and spins out of control does it cause cell death, Snyder explains.

Moreover, her studies are the first to indicate that therapies targeted at controlling the properties of smooth muscle cells within lesions may be highly effective in treating a disease that is the leading cause of death worldwide.

By measuring changes in the levels of proteins that control each cell death program and by observing the cells» physical changes, the team saw clearly that cocaine causes neuronal cell death through out - of - control autophagy.

They further show that this diterpine downregulates HMG CoA reductase offering support to the concept that mevalonate deprivation causes cell cycle arrest at the G1 phase leading to apoptotic death of the prostate carcinoma cells.

«The key thing is that we've moved away from a disease - specific mechanism to a more generic cause of cell death,» she says.

Slowing metabolism — and thus oxygen use — would delay or eliminate the formation of molecules that cause inflammation and cell death, he says.

«Severe stress affects the size of the structures in the brain, causes cell death, and affects the number of connections between brain cells,» observes Kalin.

Dr. Steven R. Goodman, Editor - in - Chief of Experimental Biology and Medicine, said «This study by Huanbiao Mo and colleagues at the Texas Woman's University and UT Southwestern Medical Center demonstrates that geranylgeraniol causes dose dependent apoptotic death of human prostate carcinoma cells.

It's known that when neurons are exposed to these clumps, they trigger an excess of calcium leaking into the cell, which can cause their death.

Accumulation of toxic prions triggers the death of nerve cells and literally leaves holes in the brain, causing a spongiform (or sponge - like) appearance.

Meanwhile, other groups developed new ways of killing bacteria with vancomycin: One alteration found a novel way to halt cell wall construction, whereas another caused the outer wall membrane to leak, leading to cell death.

A new study led by University of Kentucky researchers suggests that activating the tumor suppressor p53 in normal cells causes them to secrete Par - 4, another potent tumor suppressor protein that induces cell death in cancer cells.

Analysis of PAL identified high levels of hydrogen peroxide, which is a known anti-tumor factor and the probable cause of cell death.

All of the diseases, which cause the death of brain cells involved in controlling body movements, have recently been traced to specific genes.

In order to be able to treat neurodegenerative disorders in future, researcher Ulrich Hartl, Head of the Department of Cellular Biochemistry at the Max Planck Institute of Biochemistry, and his team have for many years been studying the cellular causes for the death of nerve cells.

Significantly, disabling both anti-apoptotic proteins, Bcl - 2 and Bcl - xL, in conjunction with Mcl - 1, caused profound cell death of leukemia cells in the test tube as well as in animal models of AML.

The National Highway Traffic Safety Administration (NHTSA) determined as far back as 2003 that cell phone use — both phone calls and text messaging — while driving causes hundreds of thousands of car accidents and hundreds of crash - related deaths.

«In this exciting new study, the authors provide support for a new experimental treatment approach that works by helping nerve cells digest toxic proteins that might otherwise cause cell death,» said John Krystal, Editor of Biological Psychiatry.

After 10 days of age, the manipulations reduced the distance flies could climb up tubes and the alterations caused older flies to have signs of neurodegeneration, including higher than normal levels of brain cell death and degradation.

«This is important because the death of photoreceptor cells is known to cause retinal degenerative diseases in humans that lead to blindness.

Depletion of five SSUP proteins (Imp4, Mpp10 / Mphosph10, Wdr36, Wdr46, and Wdr75) resulted in a reduction of Nanog expression, and the absence of one SSUP component (Cirh1a) caused cell death.