Not exact matches
Payne keyed in the symptoms, and the computer program suggested a handful
of potential conditions, including a rare disease called
amyloidosis, in which abnormal proteins build up in the body, interfering with normal organ function and
causing nerve damage.
The researchers also examined skin slices from two patients with another form
of nerve disease called AL
amyloidosis,
caused by a bone marrow disorder.
People with the transthyretin
amyloidosis have mutations in the DNA
of the transthyretin gene, which
causes abnormal buildup and deposits
of a transport protein called transthyretin in nerve and heart cells.
The nature
of those plaques finally came into focus in 1984, when George Glenner, a research scientist at the University
of California, San Diego, identified the peptide called amyloid - beta and hypothesized that Alzheimer's was
caused by «
amyloidosis»
of the brain, a process in which insoluble forms
of an amyloid protein accumulate.
Cyclic Hematopoiesis with color dilution AP3B1 ELANE mutation
causing cycles
of low wbc (white blood cell production) in collies predispose these dogs to secondary bacterial infections and
amyloidosis, and most die less then one year
of age.
Over the years, veterinarians have suggested that antigen / antibody accumulation (immune complexes),
amyloidosis, high protein diets or even leptospirosis (specific ref) might be the root
cause of kidney decline over time.
Share Pei fever can also lead to
Amyloidosis, an enzyme deficiency results in abnormal accumulations
of amyloid proteins,
causing liver or kidney failure.
The next
cause is
Amyloidosis, which is a relatively uncommon disorder
of protein metabolism in dogs.
We must verify cases
of renal
amyloidosis or other
causes of kidney failure if we are to make headway in correcting this condition through breeding.
While
amyloidosis may present itself as a symptom
of another medical condition, for those suffering from amyloid disease, the
cause will be due to issues within the actual bone marrow whereby abnormal antibodies are produced forming amyloid.