In a series
of experiments reported in PLOS ONE in August, the Tufts researchers showed that exosomes from PC12
cells (neuron - like progenitor
cells derived from rats) at various stages
of their own
differentiation could, in turn,
cause hMSCs to become neuron - like
cells.
TTD - specific cutaneous and anaemic features, on the other hand, are thought to result from a specific kind
of transcriptional insufficiency
caused by depletion
of unstable TFIIH during the terminal
differentiation of skin, hair - shaft, and blood
cells [16,24].
She is registred to the National Order
of Biologists in the province
of Palermo; collaboration in research project from 2012 to 2015 at the Department
of Biopathology and Biotechnology, University
of Palermo, focusing the study on the identification
of molecules capable to modulate intracellular metabolic pathways for the prevention and treatment
of infectious, tumor and degenerative disease, in collaboration with Prof. Angela Santoni, University
of Rome; collaboration in research project in 2011 at the hospital «Villa Sofia Cervello»
of Palermo to study methods can cure the genetic defect that
causes thalassemia through genetic engineering; she studies different mechanisms
of the
differentiation and the activation
of human gammadelta T
cells as effector
cells of the immune response against cancer and infectious diseases; she investigates about the identification and development
of biomarkers
of resistance and susceptibility to Mycobacterium tuberculosis infection; Valentina Orlando has published 13 papers in peer reviewed journals and 3 comunications at national and international congress.