Sentences with phrase «causes sickle cell anemia»

The most famous one is the gene that causes sickle cell anemia: While two copies of that gene cause a disease that's devastating in its own right, a single copy creates a healthy child with strong malarial resistance.

This is key to using CRISPR for gene therapy to, say, repair a mutation that causes sickle cell anemia or hemophilia.

The mutation that causes sickle cell anemia most probably became dominant because it gave some protection against malaria — but at a cost of its own.

But in the living world, crystals, like the ones formed by cocoa butter in chocolate or ill - formed ones that cause sickle cell anemia, are made from molecules that are long and floppy and contain a lengthy well - defined sequence of many atoms.

Not exact matches

Sickle cell anemia is caused by a genetic mutation that leads to «sickling» of the red blood cells.

Sickle cell anemia is an inherited blood disorder that causes red blood cells, which are normally...

This elusive stability must be achieved before stem cell supplies can be kept on hand until it is time to turn them into replacements for say misshapen red blood cells seen in sickle cell anemia or abnormal white blood cells causing leukemia.

It could be a more complicated version of the familiar case of sickle cell anemia: having two mutant copies of a certain gene causes the disease, whereas having only one mutant copy provides protection against malaria.

In people with sickle cell anemia, molecules of sickle hemoglobin clump together and form long rods that cause red blood cells to become rigid and take on a sickle shape.

In sickle cell anemia, a single genetic mutation leads to abnormal, crescent - shaped red blood cells that clot in tiny blood vessels throughout the body, causing severe pain and eventual organ damage.

The primary cause of anemia is iron deficiency, but it can co-occur with other conditions, such as malaria and genetic disorders like sickle cell.

Other plans include using CRISPR to reverse blood disorders, such as sickle cell anemia and beta thalassemia, caused by mutations in the hemoglobin gene.

On the other end of the spectrum are Mendelian diseases such as cystic fibrosis and sickle - cell anemia, which are caused by abnormalities to a single gene.

Silent strokes are frequent in sickle cell anemia (the most common form of sickle cell disease), occurring in approximately 3 percent of school - age children with the disease, and can cause poor school performance and limit performance of complex tasks.

Over the next few years, similar maternal blood tests could detect hundreds of diseases caused by chromosome abnormalities or mutations, including cystic fibrosis, sickle cell anemia, Tay - Sachs disease, and genetic deafness and blindness.

Although the blood disorder sickle - cell anemia was first described for medical science early in the 20th century, it was not until 1956 that researchers pinpointed its cause: a single change in a nucleotide in the gene that codes for the oxygen - carrying molecule hemoglobin.

They then used the so - called induced pluripotent stem cells (IPS cells) to reverse a mouse version of the genetic disorder sickle - cell anemia, which causes normally circular red blood cells to form sickle - shaped, thereby impeding blood flow.

Other genetic diseases include Tay - Sachs disease (damage to the gene for the enzyme hexosaminidase A leads to an accumulation of a chemical in the brain that destroys it), sickle cell anemia (improper coding of the gene that produces hemoglobin), hemophilia (lack of a gene for a blood - clotting factor) and muscular dystrophy (caused by a defective gene on the X chromosome).

In this way, the mutation is somewhat similar to sickle cell anemia in humans, where having one copy of a mutated gene gives one an immunity to malaria, while two copies causes a painful, life - threatening illness.

Working in human cells, Liu and coworkers used adenine base editing to correct a point mutation that causes the iron - storage disorder hemochromatosis and to install mutations that protect against sickle cell anemia.

What's more, inherited diseases can arise from a problem with one gene (a simple example is sickle - cell anemia, a condition caused by defects in a single gene that makes the hemoglobin protein), or from interactions among a range of genetic variations as well as, frequently, environmental stresses.

In contrast to Mendelian disorders (e.g., Huntington's disease, sickle cell anemia) in which variation in a single gene causes disease, common complex disorders, such as heart disease, diabetes, and most cancers, develop as a result of both genetic and environmental factors.

Anemia can be triggered by blood loss, a folic acid or vitamin B12 deficiency, sickle cell disease, and a genetic disorder called thalassemia, among other causes.

Examples of impairments are medical conditions like sickle cell anemia, which can cause a student to miss several days of school.

But I have a couple of good Chem books now, including Linus Pauling; whom I once had the privilege of listening to; in a lecture on the molecular causes of Sickle cell anemia; which is a problem of molecular shape (Haemoglobin).