Sentences with phrase «causes tumor formation»

Loss of this function causes tumor formation through uncontrolled stimulation of AKT, an enzyme that stimulates cell proliferation and survival and is often hyperactive in human tumors.

By using a strategy to target DNA methylation directly to the p16 promoter in mice, epigenetic inactivation of p16 function has been demonstrated unequivocally to cause tumor formation (Yu et al. 2015).

Not exact matches

Tumor metastasis is a leading cause of patient morbidity and mortality, and no treatments are currently available that specifically target metastasis formation.

Yet, Hockemeyer says, telomerase levels are marginal, resulting is some unprotected chromosome ends in the surviving mutant cells, which could cause mutations and further fuel tumor formation.

In a study, published in Science, they investigated a gene region that contains a particular single nucleotide variant associated with increased risk for developing colorectal and prostate cancers — and found that removing this region caused dramatic resistance to tumor formation.

Inhibition of ROS induced by reflux may be a useful strategy for preventing DNA damage and decreasing the risk for tumor formation caused by GERD, they concluded.

Cancer - causing viruses typically contain oncogenes, genes that induce the formation of tumors.

Despite a large amount of work that has concentrated on understanding colon tumor formation, we still do not know the full complement of molecular lesions that are individually necessary (and together sufficient) to cause colorectal cancer.

Nevertheless, there has always been the nagging question: Does tumor hypermethylation at the p16 locus cause or result from cancer formation?

In cancer, researchers suspect that amplification causes an overproduction of SOX2 proteins that, in turn, reignites and sustains cell growth associated with tumor formation.

However, when these mice were tested for the ability to form tumours after activation of an oncogenic signal that causes colorectal cancer in humans, they showed dramatic resistance to tumor formation.

The exact cause of mastocytoma in dogs remains a mystery, although the current observation is that certain breeds of dogs such as Boston terriers, Labrador Retrievers, Boxers, Pugs, Beagles, Schnauzers, and Bulldogs seem to be more vulnerable to the formation of mast cell tumors.

Acute onset in a mature animal is more likely to be secondary to injury or tumor formation, where scar tissue or cancer deforms the edge of the eyelid causing it to invert onto the eye.