Sentences with phrase «causing early onset»

But the possibility also exists that there is another, as yet uncharacterized, mutation causing Early Onset PRA in the Portuguese Water Dog.

The beverages industry says neither this study nor the body of science show that sugar - sweetened beverage consumption causes early onset of menarche.

«Neither this study nor the body of science shows that sugar - sweetened beverage consumption causes early onset of menarche.

BubR1 insufficiency causes early onset of aging - associated phenotypes and infertility in mice.

Magnesium can also prevent calcium build up on the lens which can cause early onset cataracts.

The early menopause: Thyroid problems may cause an early onset of the menopause.

Gitelman syndrome, an inherited condition affecting 1 % of Caucasians, seems to cause early onset pseudogout.

The mutation in NPHP4 described above, that causes an early onset cone - rod dystrophy in standard wire - haired dachshunds [49] was not present in the dachshunds studies by Miyadera, enabling that mutation to be excluded.

Not exact matches

Most women don't understand that the incidence of endocrine disruptive disorders such as endometriosis, fibroids, polycystic ovarian syndrome, infertility, early onset puberty, early onset menopause, heavy, painful and prolonged periods and breast cancer are mainly caused by the endocrine disruptive chemicals found in skin, hair, beauty and personal products.

Early onset drinking can cause problems not only while they are still teens, but also later in life.

As a number of neuroimaging studies show, the early onset of permanent blindness alters the response of the neurons of the visual cortex and causes a cortical compensatory re-organization in the occipital lobe.

One study, known as DIAN TU, will administer experimental drugs to more than 160 people in the U.S., the U.K., and Australia who have one of three mutant genes that cause an early - onset version of the disease.

Yes, the disorder prompted the early onset of cancer and heart disease and osteoporosis, but it did not cause Alzheimer's disease.

Mutations that detrimentally affect the function of neuronal KV7 channels cause hyperexcitability syndromes such as benign familial neonatal seizures, early onset epileptic encephalopathy, and peripheral nerve hyperexcitability.

Early onset conduct problems (e.g. lying, fighting) and attention - deficit / hyperactivity disorder (ADHD) are the leading causes of child mental health referral in the UK.

Having too many repeated elements in the gene sequence causes the disease and an increasing number of repeats leads to earlier onset and increased severity of the disease.

The mutation causing this form of early - onset Alzheimer's is called E280A and is found in a gene on chromosome 14.

Having too many repeated elements in the gene sequence causes the disease and an increasing number of repeats leads to earlier onset and increased severity of the condition.

Several of these changes increase β amyloid formation and cause a devastating inherited form of Alzheimer's that afflicts people in their 30s and 40s — much earlier than the far more common «late - onset» form of Alzheimer's that typically strikes people their 70s and 80s.

In Yarumal and the surrounding state of Antioquia, 5000 people carry a gene mutation which causes early - onset Alzheimer's — half of them will be diagnosed by the age of 45, and the other half will succumb by the time they are 65.

Human amyloid precursor protein (hAPP) transgenic mice from line J20, which carry mutations that cause early - onset AD (7), show major deficits in this assay (8).

It is now known to be a form of early onset Alzheimer's, caused by a mutation in a gene called PSEN1.

Mutations in APP, PSEN1, and PSEN2 cause autosomal dominant early - onset (mostly

This can be caused by a number of spinal deformities such as congenital scoliosis, missing ribs, fused ribs, deformed vertebrae, or other types of severe early onset scoliosis.

Our main goal in this project is to use NGS in identification of genetic causes of rare / ultrarare early - onset neurologic diseases, integrating «omics» platforms with systematic approaches to enrich and redefine phenotypic ontology in these conditions, allowing a comprehensive analysis of genomic data.

Working with Nancy Cox, PhD, professor of medicine and human genetics and section chief of genetic medicine at the University of Chicago, Bell discovered mutations in the genes for glucokinase and for three transcription factors that cause an early - onset form of diabetes called maturity - onset diabetes of the young.

For example, TDP - 43 toxicity has also been observed in frontotemporal dementia (FTD), a form of early - onset dementia that causes progressive memory loss.

Another limitation is its inclusion of patients with severe early - onset heart disease, which is more likely to have genetic causes than milder disease.

Repeats tend to get longer, on average causing children to have earlier onset than their parents.

These PS1 mutations, Q222H and M233T, are completely penetrant causing early - onset familial AD as previously reported in these Australian families.

FOXP3 mutations causing early - onset insulin - requiring diabetes but without other features of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.

Compound heterozygous mutations in UBA5 causing early - onset epileptic encephalopathy in two sisters.

Early onset autosomal recessive parkinsonism is caused by mutations in the parkin, PINK1, and DJ - 1 genes (Kitada et al., 1998; Bonifati et al., 2003; Valente et al., 2004).

Adipose specific disruption of seipin causes early - onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease

We imputed these variants into 104,220 individuals down to a minor allele frequency of 0.1 % and found a recessive frameshift mutation in MYL4 that causes early - onset atrial fibrillation, several mutations in ABCB4 that increase risk of liver diseases and an intronic variant in GNAS associating with increased thyroid - stimulating hormone levels when maternally inherited.

Conclusions: Our findings demonstrate that disruption of Bscl2 specifically in developing adipocytes is sufficient to cause the early - onset generalised lipodystrophy observed in patients with mutations in BSCL2.

What's more, they further discovered that increased levels of fatty acids caused increased insulin resistance, which is the main indicator of the early onset of diabetes.

It is usually found in early onset cases, before the ages of 35 to 45, when there are no other identifiable causes.

When glycogen stores are low, they will become more rapidly depleted during exercise, causing an earlier fatigue onset and decreased performance.

When glycogen stores are low, they will become more rapidd depleted during exercise causing an earlier fatigue onset and decreased performance.

Dr. Carnahan then covers Dr. Dale Bredesen's subtypes of early - onset dementia which allows you to treat the root cause and actually reverse symptoms.

Early pregnancy is often associated with the onset of nausea, vomiting and appetite loss (this is often referred to as the «pregnancy signal»), which in turn may cause a reduction in coffee consumption, and hence, caffeine intake from coffee1, 6,7.

The researchers also noted that HPA Axis Dysfunction is not present at all at the onset or during the early stages of CFS, and thus, the evidence doesn't support the notion that HPA Axis Dysfunction is the cause.

Since cortisol abnormalities are not typically present at the onset or early stages of chronic fatigue, and since cortisol abnormalities are not present at all in the vast majority of people with chronic fatigue, a reversed direction of causation — where cortisol abnormalities are caused by other factors, inactivity, medication use, poor sleep, etc. — is the most compelling explanation for cortisol abnormalities, in the minority of people with chronic fatigue who do have them.

Naturally, if HPA - Axis dysfunction were the cause of chronic fatigue, it should be present and detectable in the onset and early stages of the disease.

It's not accurate to claim that something is the cause, when that thing isn't even detectable at the onset or early stages of chronic fatigue.

Anabolic steroids cause muscle hypertrophy of both types (I and II) of muscle fibers caused likely by an increased synthesis of muscle proteins and are accompanied with undesired side effects including hepatotoxicity, gynecomastia, acne, the early onset of male pattern baldness and a decline in the body's own testosterone production, which can cause testicular atrophy.

While doctors don't know why some instances of early onset happen, scientists have isolated rare genes that can directly cause it in a many cases.

- Booklist «More accessible than her somber first book, which dealt with early - onset Alzheimer's, the central condition causes readers to wonder what brain disease she will think of next.»

An early onset form of lysosomal storage disease, this can cause affected dogs to display neurologic signs as puppies or young adults.