Vacuolating cytotoxin A (VacA) was previously the only main H. pylori factor known to act on mitochondria,
causing cellular membrane and organelle dysfunction and leading to cell death.
Not exact matches
Wolfram syndrome is
caused by a mutation in the gene encoding a protein called wolframin, which resides in the
membrane of the endoplasmic reticulum — another
cellular compartment that functions as a manufacturing and packaging system and also acts as a reservoir for calcium ions.
Peroxynitrates results in lipid peroxidation of
membranes and
cause disturbances in tissue homeostasis that is severe enough to
cause cellular damage and eventually cell death (Beattie et al., 2000).
These channels, which derive their name from the fact that stretching the cell
membrane causes them to open, are responsible for regulating the mechanical functioning of cells — a
cellular sense of touch.
They are highly reactive radicals that can start a chain reaction in the body, such as damaging
cellular components, like DNA or the cell
membrane,
causing cells to function poorly or die.
When our cells use oxygen, they naturally produce «free radicals» (by - products) which
cause damage to our DNA, cell
membranes and
cellular organelles.
Cyanide
causes damage at the
cellular level because it blocks oxygen transport across the cell
membrane.