Sentences with phrase «causing gene alterations»

Not exact matches

For instance, alterations to these chemical switches can change the architecture of the heterochromatin, causing genes to be expressed or silenced.

Douglas Thomas, associate professor of medicinal chemistry and pharmacognosy at UIC, and co-workers discovered that nitric oxide plays an important role in epigenetics — heritable alterations in gene expression caused by mechanisms other than changes in DNA sequence.

Using clinical, genetic, and gene expression data as filters to distinguish genes whose copy number alteration causes cancer from those for whom copy number changes are incidental, the team whittled down their list from 14,000 to a more manageable number, each of which they systematically tested using genetic experiments in animals.

Some of the common genetic alterations identified in the study were gains and losses in chromosome 8, as well as cell proliferation and cell - cycle progression — key mechanisms of cancer caused by genetic alterations — linked to the genes AURKA, AURKB and FOXM1.

One of the mechanisms driving alterations in gene expression is epigenetic change, where the female is able to change her offspring's genome to cause certain genes to be expressed differently.

Another 20 % of patients have alterations causing chromosomal disorganization and the consequent malfunctioning of several genes and proteins.

The alteration of this group of genes could cause memory loss in the initial stages of Alzheimer's disease.

Utilizing the invasive breast cancer data set of 962 cases in The Cancer Genome Atlas, all breast cancers with alterations in the CDH1 gene (that gives instructions to make a protein that causes cancer cells to stick to one another and defines lobular breast cancers) were identified.

In a collaborative study, researchers from Chinese Academy of Medical Sciences and Peking Union Medical College, BGI, Shantou University Medical College and other institutions identified important alterations of tumor - associated genes and tumorigenic pathways in esophageal squamous cell cancer (ESCC), one of the leading cause of cancer death worldwide.

(B) Gene drives can increase this chance to nearly 100 % by cutting homologous chromosomes lacking the alteration, which can cause the cell to copy the altered gene and the drive when it fixes the damGene drives can increase this chance to nearly 100 % by cutting homologous chromosomes lacking the alteration, which can cause the cell to copy the altered gene and the drive when it fixes the damgene and the drive when it fixes the damage.

Epigenetics is the study of changes in organisms caused by modifying gene expression — by alcohol, for example — rather than alteration of the genetic code itself.

In the course of this work, he has pioneered several new approaches in the fruit fly that have had important implications for mammalian neurobiology, including: the demonstration that the fruit fly has a sleep - like behavior similar to that of mammals, studies of physiological and behavioral consequences of mutations in a neurotransmitter system affecting one of the brain's principal chemical signals, studies making highly localized genetic alterations in the nervous system to alter behavior, and molecular identification of genes causing naturally occurring variation in behavior.

They found that early phenformin treatment causes increased survival and slower tumor progression in tumors lacking LKB1, but had no significant benefit for tumors with alterations in other lung cancer genes.

Combination of methamphetamine and HIV - 1 gp120 causes distinct long - term alterations of behavior, gene expression, and injury in the central nervous system.

Expression of mutant Ets protein at the neuromuscular synapse causes alterations in morphology and gene expression

Genetic Alterations: Disruption caused by insertion of the retroviral gene trap vector ROSAFARY.

Dr. Verma's major research interests are oncogenes and tumor suppressors, normal genes whose alteration can cause cancer, and the development of techniques for gene therapy.

Researchers found that particles in exhaust from cars and trucks can cause epigenetic changes — alterations that affect how genes are switched on and off without changing the DNA sequence itself.

The causes of the widespread differential expression of non-coding RNAs in malignant compared with normal cells can be explained by the location of these genes in cancer - associated genomic regions, by epigenetic mechanisms and by alterations in the processing machinery.

The long - term goals of my laboratory are to understand how alterations in the RB1 and TP53 tumor suppressor gene regulatory networks cause cancer.

A study led by St. Jude Children's Research Hospital shows epigenetic changes that turn genes on and off are as unique as alterations in DNA and may be as important in causing the most common childhood cancer

Changes in an epigenetic mechanism that turns expression of genes on and off may be as important as genetic alterations in causing pediatric acute lymphoblastic leukemia (ALL), according to a study led by scientists at St. Jude Children's Research Hospital and published in the June 10 online edition of the Journal of Clinical Investigation.

A study published last year suggesting CRISPR gene - editing can cause hundreds of unintended alterations has officially been retracted by the scientific journal Nature Methods (Credit: < a href ="https://depositphotos.com/166615506/stock-photo-genetic-engineering-gmo-and-gene.html" rel="nofollow"> vchalup2 / Depositphotos )

A study published last year suggesting CRISPR gene - editing can cause hundreds of unintended alterations has officially been retracted by the scientific journal Nature Methods (Credit: vchalup2 / Depositphotos)

These procedures generate animals that carry specific genetic alterations, and recreate the underlying cause of a human disorder or uncover the role of any gene of interest.

They cause an alteration in gene expression, leading to a suppression of key mitochondrial enzymes, like carnitine palmitoyltransferase — which finally solves the mystery of why those eating vegetarian have a 60 % higher expression of that fat - burning enzyme.