Sentences with phrase «causing gene fusions»

By engineering an artificial protein that targets the product of such potentially cancer - causing gene fusions, Hur hopes to trigger immune defense mechanisms that kill rogue cells harboring the fusions.

Not exact matches

Because of a chromosomal abnormality, this gene sometimes fuses with another gene and forms a hybrid, or a gene fusion, resulting in a gene product with an entirely different function, causing cancers.

This gene fusion, T2: ERG, is believed to cause prostate cancer.

A mutation in either gene causes it to combine with a partner gene to express an abnormal fusion protein that acts along a cellular growth pathway to result in cancer.

Scientists have discovered a new «mastermind fusion gene» may be associated with a rare cancer - causing tumor — pheochromocytomas («pheo») and paragangliomas, according to a study published Feb. 13 in Cancer Cell, by researchers at the Uniformed Services University (USU) and the National Cancer Institutes» The Cancer Genome Atlas.

In a 2012 study published in Science, the CUMC team found that some cases of glioblastoma, the most common and aggressive form of primary brain cancer, are caused by the fusion of two genes, FGFR3 and TACC3.

Importantly, the fusion of the TEL and AML1 genes is not sufficient to cause development of the disease, known as «common acute lymphoblastic leukemia,» the researchers said.

(Chronic myeloid leukemia, a deadly blood cancer, for example, is caused when two chromosomes in white blood cells exchange fragments, resulting in a hapless fusion of genes that are normally kept apart.)

Previous reports have shown that in a genetic abnormality called Philadelphia chromosome, fusion of ABL and BCR genes cause leukemia.