In April 2015, researchers in China reported that they had used CRISPR, with limited success, to repair a disease -
causing gene in human embryos.
Not exact matches
In April, Chinese researchers working with non-viable
human embryos (those that would never end up turning into people) used it to try to tweak a
gene that would normally have
caused a rare blood disorder.
Earlier versions of these «base editors,» which target typos related to the other half of disease -
causing genetic spelling errors, have already been used to alter
genes in plants, fish, mice and even
human embryos.
Then for HARE5, the most active enhancer
in an area of the brain called the cortex, they made minigenes containing either the chimp or
human version of the enhancer linked to a «reporter»
gene that
caused the developing mouse
embryo to turn blue wherever the enhancer turned the
gene on.
Now a trial has successfully repaired a disease -
causing mutation
in a
human embryo, which would prevent that
gene from being passed down to future generations.
Scientists achieve first safe repair of single -
gene mutation
in human embryos Scientists have, for the first time, corrected a disease -
causing mutation
in early stage
human embryos with
gene... Read more