Sentences with phrase «causing genes in mice»

Northwestern Medicine scientists have identified a small RNA molecule called miR - 182 that can suppress cancer - causing genes in mice with glioblastoma mulitforme (GBM), a deadly and incurable type of brain tumor.

The team used CRISPR to fix a blindness - causing gene in mice.

Not exact matches

Mice trapped in New York City apartment buildings harbored disease - causing bacteria and antibiotic resistance genes.

Their report, published May 10 in the journal Nature Communications, suggests that among more than a dozen different lines of mice developed around the world to mirror autism caused by mutations to the SHANK3 gene, Duke researchers are the first to create a mouse in which that gene has been completely eliminated.

Jiang said autism researchers worldwide could use the mouse model to study ways to compensate for the gene and improve symptoms in people with autism spectrum disorders and Phelan - McDermid Syndrome, a more profound developmental condition caused by mutations to SHANK3 and other genes in chromosome 22.

The less adept mice, Rubin's team found, carry extra copies of a previously known human gene called DYRK; a mutated version of an almost identical gene in fruit flies, called minibrain, causes neurological defects.

The researchers used the dead guide RNAs to turn on the Pdx gene in the mice's livers, which caused the liver cells to produce insulin, reversing the mice's diabetes.

To determine if defects in the atrial natriuretic peptide (ANP) system can cause hypertension, mice were generated with a disruption of the proANP gene.

In Huntington's disease, mice carrying the pathologic genetic variant of the huntingtin gene are being used to understand how this genetic lesion causes degeneration of striatal neurons and to develop novel treatments for the illness.

Since patients (and mice) with Usher 1c also have balance problems caused by hair - cell damage in the vestibular organs, the researchers also tested whether gene therapy restored balance.

Scientists have known for 20 years that SMN is necessary in every cell of the body, since disrupting the gene in a mouse causes early embryonic death, before muscle or nerve cells form.

What's more clear, says Dougherty, is how disabling this gene can cause mice to behave in a way that is reminiscent of depression.

To avoid that muddle, Steve Brown and Xue - Zhong Liu, molecular biologists at the Medical Research Council's Mouse Genome Center in Harwell, England, sought families in remote areas of the world, where the families» deafness is more likely to be caused by a single mutated gene.

But researchers have found a mutation in a mouse gene that leads to an arthritis - like condition because it causes the joint's cartilage cells to pump insufficient amounts of pyrophosphate — a natural water softener — into the joint cleft.

Dr. Timothy Cox, a craniofacial researcher at Seattle Children's Research Institute and lead author, found that mice with a gene mutation that causes cleft lip and palate had problems in their salivary glands that affected gum tissue and oral health.

High's gene therapy had cured hemophilia in mice and dogs and had caused rhesus monkeys to express clotting factors.

The current JBMR study extended that research by using palovarotene in a mouse model carrying the same human gene mutation that causes FOP.

In a study of mice, they found that they could correct the mutated gene that causes a rare liver disorder, in 6 percent of liver cells — enough to cure the mice of the disease, known as tyrosinemiIn a study of mice, they found that they could correct the mutated gene that causes a rare liver disorder, in 6 percent of liver cells — enough to cure the mice of the disease, known as tyrosinemiin 6 percent of liver cells — enough to cure the mice of the disease, known as tyrosinemia.

Further studies discovered that the BRAF protein could turn on many itch genes, and they showed similar changes of gene expression in mice with chronic itch induced by dry skin and in mice with allergic contact dermatitis, two of the skin conditions that frequently cause people to scratch incessantly.

A virus that has shown promise as a vector for human gene therapy causes liver tumors in neonatal mice.

When a male mouse is immobilized daily in a plastic tube, the spike of glucocorticoids causes extra methyl groups to be added to the Sfmbt2 gene in his sperm.

By studying how these genes cause defects in fly and mouse models, we can improve our insights into the mechanisms related to human disease,» said corresponding author and Dr. Hugo J. Bellen, professor of neuroscience and molecular and human genetics at Baylor College of Medicine and an investigator at the Howard Hughes Medical Institute.

A Johns Hopkins University team this week reported inserting a disrupted human gene, the schizophrenia risk factor DISC1, into lab mice, causing them to exhibit the brain asymmetry characteristic of schizophrenia as well as agitation in open spaces and trouble finding hidden food — traits reminiscent of the restlessness, impaired sense of smell and depressionlike symptoms schizophrenics suffer, Reuters reports.

In a closing set of experiments, the researchers examined neurons obtained from mice with the most common inherited form of ALS, one caused by mutations in a gene called SODIn a closing set of experiments, the researchers examined neurons obtained from mice with the most common inherited form of ALS, one caused by mutations in a gene called SODin a gene called SOD1.

Using CRISPR - Cas9 gene editing in mice, the researchers confirmed that mutations in these two genes can cause HLHS.

In this study, by using a systemic mtEF4 gene knockout mouse model, researchers found that mtEF4 knockout damages the oxidative phosphorylation function in germ cells of male mice, thus causing male sterilitIn this study, by using a systemic mtEF4 gene knockout mouse model, researchers found that mtEF4 knockout damages the oxidative phosphorylation function in germ cells of male mice, thus causing male sterilitin germ cells of male mice, thus causing male sterility.

Researchers at The Rockefeller University have shown that a new technique using RNA interference is able to find genes that cause epidermal tumor growth in months rather than the decades it may take using traditional methods employing specially bred, genetically altered mice.

Studies in typical model animals — mice — are rarely illuminating, because the rodents often still behave normally when researchers manipulate genes that should cause these disorders.

The research, the cover story of this month's Science Advances, builds upon previous studies from Dr. Olson in which CRISPR - Cas9 corrected a single gene mutation that caused DMD in mice.

Now that they have a FAN1 knockout mouse in hand, and they have confirmed that it mimics many aspects of karyomegalic interstitial nephritis in humans, Smogorzewska's lab can start to delve into how the loss of the gene causes kidney degeneration.

Earlier versions of these «base editors,» which target typos related to the other half of disease - causing genetic spelling errors, have already been used to alter genes in plants, fish, mice and even human embryos.

Then for HARE5, the most active enhancer in an area of the brain called the cortex, they made minigenes containing either the chimp or human version of the enhancer linked to a «reporter» gene that caused the developing mouse embryo to turn blue wherever the enhancer turned the gene on.

To study diseases that cause blindness in people, scientists typically genetically «knock out» cone - related genes in animals like mice.

It was then that they discovered the gene deletion had caused thin heart walls and other cardiac problems in developing mice embryos.

David Liu at Harvard University and his colleagues have tried doing this with CRISPR in mice carrying a mutated copy of the gene TMC1, which causes a rare form of hearing loss in people.

Scientists at Mayo Clinic, Jacksonville, Florida created a novel mouse that exhibits the symptoms and neurodegeneration associated with the most common genetic forms of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), both of which are caused by a mutation in the a gene called C9ORF72.

In other research, a knockout of the gene that encodes one type of lncRNA in mice conferred some resistance to obesity caused by a high - fat dieIn other research, a knockout of the gene that encodes one type of lncRNA in mice conferred some resistance to obesity caused by a high - fat diein mice conferred some resistance to obesity caused by a high - fat diet.

Adult mice don't need the gene that, when mutated in humans, causes the inherited neurodegenerative disorder Huntington's disease. The finding suggests that treatment strategies for Huntington's that aim to shut off the huntingtin gene in adults — now in early clinical stages — could be safe.

«Following the trajectory of type 1 diabetes in the mice, and looking at what genes become active in the microbes and in the immune system, we think we can pinpoint some of these mechanisms that are important, if indeed the microbiome is causing diabetes,» Kostic says.

An international team of scientists, including four from Brown University, conducted and analyzed tests using a «knock - in» mouse carrying a gene for a mutant DNA / RNA binding protein called TDP - 43, which causes a form of inherited ALS in humans.

Hermansky - Pudlak syndrome is caused by mutations in HPS4, the human homolog of the mouse light - ear gene.

Loss of Vascular Endothelial Growth Factor A (VEGFA) Isoforms in the Testes of Male Mice Causes Subfertility, Reduces Sperm Numbers, and Alters Expression of Genes That Regulate Undifferentiated Spermatogonia.

In a 2015 Nature Communications paper, Rao, who heads LJI's Division of Signaling and Gene Expression, reported that TET2 / 3 mutations caused myeloid disease resembling acute myeloid leukemia in micIn a 2015 Nature Communications paper, Rao, who heads LJI's Division of Signaling and Gene Expression, reported that TET2 / 3 mutations caused myeloid disease resembling acute myeloid leukemia in micin mice.

Following a Forward Genetics approach, Fleming researchers identified a novel neurological mouse model caused by a functional mutation in the Slc25a46 gene, a new pathogenic target in a wide spectrum of human neurological diseases, including optic atrophy, Charcot - Marie - Tooth type 2, Leigh syndrome, progressive myoclonic ataxia and lethal congenital pontocerebellar hypoplasia.

The researchers chose to explore its potential in mice with a dominant cataract disorder caused by a single copy of a gene known as Crygc.

Mutations occurring in this gene cause polycystic kidney disease and type II diabetes both in human and mice

«Historically, we have had trouble modeling human diseases caused by mutation of just one copy of a gene in mice, which impedes research on complex conditions and limits our discovery of therapeutics,» explained Srivastava, director of the Gladstone Institute of Cardiovascular Disease and senior author on the study.

The recent Nature paper «High - throughput discovery of novel developmental phenotypes» describes the systematic high - throughput phenotyping screens used in the knock out mice and gives insight into a variety of gene function while a strong correlation was found between genes causing lethality in mice and genes causing diseases in humans, including cardiovascular defects, spina bifida, and metabolic disorders, among many others.

Mice have been injected with genes that may cause Alzheimer's disease in an effort to find a cure.

By manipulating a specific gene in a mouse blastocyst — the structure that develops from a fertilized egg but is not yet an actual embryo — scientists with the University of Florida's McKnight Brain Institute and the Harvard Stem Cell Institute caused cells destined to build an embryo to instead change direction and build the cell mass that leads to the placenta.