Sentences with phrase «causing immune cells»

They had more inflammation - causing immune cells in their brains, as expected, but they also stopped making new brain cells.

As expected, the mice had more microglia activation and other inflammation - causing immune cells in their brains.

Now a report in this month's issue of Nature Medicine may provide an explanation: A key bone marrow protein causes immune cells in mouse transplant recipients to self - destruct.

In their report published in Science Immunology they describe how expression of a specific molecule — complement C5a — is required to cause the immune cells called neutrophils to adhere to joint surfaces and migrate into the joint, a process known to set off the inflammatory cascade.

The drug caused immune cells called macrophages to eject their cholesterol, an important effect because cholesterol - laden macrophages help trigger artery - blocking plaques.

The new biologic drugs help patients by blunting the signal that causes immune cells to attack the intestinal tract, Wheaton said.

The researchers explain that exercise will cause immune cells to change in 2 ways for those participating in endurance sports.

Injuries cause immune cells to turn on in order to begin the healing process.

When an allergen activates the immune system, it manufactures a protein that causes the immune cells to release histamine, a naturally occurring compound that has an inflammatory effect on the tissues it comes into contact with.

Not exact matches

CAR - T approaches involve reengineering T - cells to find and destroy cancer cells, but that process can cause cytokine release syndrome (CRS), a life - threatening immune response NantKwest hopes to sidestep.

If the woman's mate is too similar to her immune system, these cells are known to cause autoimmune diseases such as scleroderma.

Beta - carotene has been found to reduce cell damage caused by free radicals, and improves immune function by enhancing cell mediated immune responses.

Autoimmunity is commonly caused by bacterial infections or overgrowth in the small intestine, in which partially digested food compounds are incorporated into bacterial cell walls and then the immune system, reacting to the bacteria, forms antibodies that also recognize food compounds, some of which might cross-react with human counterparts.

Sugary drinks and fruit juice shouldn't be consumed because they will ruin your child's appetite for more nourishing food choices at the same time they cause a myriad of health issues, including the suppression of white blood cell (immune) function.

Clamping the cord, especially at an early stage, may also cause the extra blood trapped within the placenta to be forced back through the placenta into the mothers blood supply with the third stage contractions.32 33 This feto - maternal haemorrhage (FMH) increases the chance of future blood group incompatibility problems, which occur when the current baby's blood enters the mother's blood stream, causing an immune reaction which can be reactivated in a subsequent pregnancy, destroying the baby's blood cells and causing anaemia or even death.

Potassium is also very important in a diet as it causes certain immune cells to activate when there is an infection in your body.

When you or your child comes in contact with egg proteins, immune system cells (antibodies) recognize them and signal the immune system to release histamine and other chemicals that cause allergic signs and symptoms.

In the person who has psoriasis, the immune system «misfires» and inappropriately causes inflammation and an accelerated growth of skin cells.

After a person contracts chicken pox, they become immune to VZV, but it can re-activate in old age and cause shingles if T cell immune responses aren't strong enough.

In the present study, the researchers have discovered a reason for reduced fertility in people with autoimmune polyendocrine syndrome type 1 (APS1), which increases the risk of developing autoimmune disease (caused by the immune system attacking and damaging healthy cells) and which is often used as a model for autoimmune disease in general.

They discovered that in the young, more immune cells called monocytes were recruited to the lungs, and that the gene expression profiles of these cells had more inflammatory features, causing greater inflammation and more severe lung injury.

Tweaking the immune system to create CAR T cells has caused adverse reactions in some people.

«Chronic inflammation of the intestine is thought to be caused by abnormal interactions between gut microbes, intestinal epithelial cells and the immune system, but so far it has been impossible to determine how each of these factors contribute to the development of intestinal bowel disease,» said Hyun Jung Kim, Ph.D., former Wyss Technology Development Fellow and first author on the study, speaking about the limitations of conventional in vitro and animal models of bacterial overgrowth and inflammation of the intestines.

In both diabetic models, high blood sugar levels caused a significant increase in the blood counts of certain immune cells called monocytes and neutrophils.

Neutrophils are one of the most common types of immune cells and known to engulf microorganisms, but they are not normally associated with peripheral nerve damage, such as that caused by diabetes or trauma.

«Suppressing a progenitor from creating the subtype of dendritic cells implicated in causing lupus, for example, could be an efficient way of treating autoimmune diseases while minimising the impact on the rest of the immune system.

In the GD2 CAR - T treated animals, the residual cancer cells did not express GD2, suggesting that these remaining cells were not vulnerable to the immune therapy and might be able to cause the cancer to recur.

Psoriasis is a disease of the immune system in which inflammation causes skin cells to multiply faster than normal.

The most common type of skin lymphoma is caused by the fact that specific immune cells — CD4 - T - lymphocyttes — turn into cancer cells.

Infectious organisms trip specialized immune cells in the body and cause them to pump out proteins called cytokines, which produce inflammation and other hallmarks of infection, such as chills and fever.

SNAs have unique properties that allow them to reach cells safely without causing toxicity or activating the immune system.

Together, the two studies advance the idea that gut microbes play a role in turning the immune system against nerve cells, causing MS.. It will take a lot more work to develop cures or preventive strategies based on that, but the research raises the intriguing possibility of treating an often - devastating disease with something as low - tech as fecal transplants or probiotics.

Although the group didn't identify the toxin's target, it probably causes cells to die from within by overstimulating the immune system, says immunologist Harry Hill of the University of Utah.

Anything that causes tissue injury — including infection or illness as well as surgery — can activate various immune cells and cause inflammation.

Antibodies and T cells against the protein could cause the immune system to attack cells carrying it, making gene therapy ineffective.

Each of these immune cells contains DNA that codes for a protein that recognizes bacteria, viruses, allergens, cancer cells and other potential disease - causing invaders.

Published in the journal Frontiers in Neuroscience, the researchers have assembled strong evidence that the neurological decline common to these diseases is caused by «auto - inflammation», where the body's own immune system develops a persistent inflammatory response and causes brain cells to die.

The T - cells therefore believe that gluten is dangerous, and they initiate immune reactions that cause an inflammation reaction in the intestines.

Conventional transplant conditioning employs radiation and / or high - dose cytotoxic drugs (also known as alkylators) to destroy the bone marrow and blood and immune cells; it also causes widespread cellular damage throughout the body.

Using animal models of precancerous polyps in the bowel, Chung and his team determined that certain types of immune cells within a chronically inflamed intestine can become rewired, causing them — paradoxically — to contribute to disease development rather than protect against it.

Initially the innate immune system protects the tissue against these triggers, but prolonged activation becomes self - perpetuating, causing brain cell death to occur.

Another key advantage of these peptides is that while they recruit immune cells to combat the infection, they also suppress the overactive inflammatory response that can cause sepsis, a life threatening condition.

The innate immune system is the first line of defense in cells, and normally distinguishes molecules that belong to the body from foreign, disease - causing, molecules.

The disease commonly starts in childhood and causes the body's own immune system to attack and destroy the insulin - producing cells in the pancreas, leaving the patient dependent on life - long insulin injections.

In another landmark success, scientists in Italy and the United States cured «bubble» babies who have a malfunctioning gene for the enzyme adenosine deaminase, which causes a buildup of toxic products that destroy immune cells.

Studying the rodents more carefully, the researchers determined that Clostridia were having a surprising effect on the mouse gut: Acting through certain immune cells, the bacteria helped keep peanut proteins that can cause allergic reactions out of the bloodstream.

However, under certain conditions, Salmonella can subsequently cause a potentially lethal systemic typhoidal infection when they invade the underlying immune cells.

When the immune system is imbalanced, either due to overly - active cells or cells that suppress its function, it causes a wide range of diseases, from psoriasis to cancer.

Multiple sclerosis (MS) is caused by immune cells that activate a cascade of chemicals in the brain, attacking and degrading the insulation that keeps neuronal signals moving.

The new study revives suspicions that adenoviruses cause an immune «own goal», priming people's immune systems to produce CD4 cells — the very cells that HIV prefers to infect — and, worse still, to direct those cells to the parts of the body that are most vulnerable to the virus during sex.