So it's not a big stretch of the imagination to think that some change, like food additives or antibiotic use, might have
caused a fundamental,
widespread shift in gut flora, making it easier for many people to gain weight, and increasingly difficult to shed extra pounds.
The three lines are: (1) the beginning: the Khirthar transgression and the onset of neritic carbonate accumulation in the Bartonian Age (preceding onset of the Middle Eocene climatic optimum [MECO]-RRB-; (2) the midlife change (Bartonian - Priabonian transition): the
shift from carbonate - rich to carbonate - poor, higher - nutrient environments under estuarine circulation,
causing widespread dysaerobia culminating in opaline silicas; and (3) the Eocene - Oligocene = Priabonian - Rupelian boundary and glaciation during oxygen isotope event Oi - 1, with return of improved ventilation in neritic environments and resumption of carbonate accumulation.