Sentences with word «celecoxib»

«Patients receiving ibuprofen had a 61 % higher incidence of de novo hypertension compared to those receiving celecoxib,» said Professor Ruschitzka.

Fifty - five patients completed the study: 31 in the Lexapro plus celecoxib group and 24 in the Lexapro plus placebo group.

PRECISION - ABPM, 3 a pre-specified four month substudy of the landmark PRECISION trial, 4 was designed to determine the blood pressure effects of the selective COX - 2 inhibitor celecoxib compared to the non-selective NSAIDs naproxen and ibuprofen.

These results support and extend the findings of the PRECISION trial, demonstrating noninferiority for the primary cardiovascular outcomes for moderate doses of celecoxib compared with naproxen or ibuprofen.6 These findings may have the greatest clinical significance in the elderly, who have a high prevalence of arthritis and hypertension.

In the Loyola study, patients who took celecoxib began seeing a benefit from their antidepressant within a week.

Reducing inflammation with a drug such as celecoxib «reverses treatment resistance and enhances overall antidepressant response,» Dr. Halaris wrote in the study.

Giving severely depressed patients the arthritis drug celecoxib (Celebrex ®) dramatically boosted the effectiveness of their antidepressant medication, a Loyola study has found.

RISK ANALYSIS The widely prescribed painkiller Celebrex, now available as the generic celecoxib, appears to pose no greater risk to the heart than do similar drugs.

This challenges the widely advocated belief that conventional NSAIDs, like naproxen and ibuprofen, with their higher COX - 1 (and thromboxane reducing) effects would provide greater cardiovascular safety than other more COX - 2 selective agents, particularly celecoxib.»

The investigators found that celecoxib decreased the average systolic blood pressure measured over 24 hours by -0.3 mmHg while ibuprofen and naproxen increased it by 3.7 and 1.6 mmHg, respectively.

By fighting inflammation, celecoxib appears to make antidepressants more effective, Dr. Halaris said.

The resulting difference of -3.9 mmHg between celecoxib and ibuprofen was significant (p = 0.009).

These results suggest celecoxib, a pain tablet like aspirin, could bring stem cell treatment closer to reality.

So far so good, but did celecoxib have any direct effects on the stem cells themselves?

In a study recently published in the journal Cytotherapy, researchers in India discovered that treating mice with a common anti-inflammatory drug called celecoxib promoted stem cell survival and healing when they injected the cells into wounds.

The scientists found that celecoxib directly increased stem cell differentiation into keratinocytes — skin cells required for wound healing.

In order to learn more about how celecoxib was enhancing stem cell survival and wound healing, the researchers conducted experiments to identify the cytokines or enzymes directly or indirectly influencing the process.

By helping the stem cells to survive and encouraging them to differentiate into skin cells, celecoxib produced a two - pronged healing effect.

Other anti-inflammatory agents, including celecoxib, minocycline, davunetide, and fatty acids showed no significant effect.»

The pain - killer celecoxib (Celebrex) has been found in randomized, placebo - controlled trials10 to be superior to placebo in antidepressant augmentation.

see dental health celecoxib (Celebrex) Sep99 p4; Sep - Oct01 p4 celiac disease.

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In this study, special intraocular lenses containing celecoxib will be implanted in the eyes of dogs undergoing cataract surgery.

Patients were randomised in a 1:1:1 fashion to receive celecoxib (100 - 200 mg twice a day), ibuprofen (600 - 800 mg three times a day), or naproxen (375 - 500 mg twice a day) with matching placebos.

The lenses, which provide a sustained release of celecoxib, were developed by the NC State Ophthalmic Research Laboratory under the guidance of Dr. Brian Gilger, a CVM professor of ophthalmology.

In the study, known as the REACT trial, women at high risk for breast cancer are taking celecoxib to see if the drug can lower their risk.

Principal investigator Professor Frank Ruschitzka, professor of cardiology and co-head, Department of Cardiology, University Heart Centre, Zurich, Switzerland, said: «PRECISION - ABPM showed differential blood pressure effects between the different NSAIDs, ibuprofen and naproxen, and the COX - 2 inhibitor celecoxib.

For 24 weeks, 1,583 participants in the aptly named GAIT (Glucosamine / chondroitin Arthritis Intervention Trial) were given one of the following treatments: glucosamine, chondroitin sulfate, both in combination, a placebo, or the COX - 2 inhibitor Celebrex (celecoxib) as a control.

Seventy - eight percent of the patients in the celecoxib group experienced at least a 50 percent reduction in their depression scores, with 63 percent reporting their depression had gone away completely.

Ibuprofen is associated with increased blood pressure and hypertension compared to celecoxib in patients with osteoarthritis or rheumatoid arthritis and increased risk of cardiovascular disease, according to late - breaking results from the PRECISION - ABPM study presented today in a Hot Line Session at ESC Congress1 and published in EHJ.

Patients were randomly assigned to receive the antidepressant escitalopram (Lexapro ®) plus celecoxib or Lexapro plus a placebo.

While celecoxib and naproxen produced either a slight decrease (celecoxib) or a relatively small increase (naproxen) in blood pressure, ibuprofen was associated with a significant increase in ambulatory systolic blood pressure of more than 3 mmHg.»

An additional analysis showed that the percentage of patients with normal baseline blood pressure who developed hypertension5 was 23.2 % for ibuprofen, 19.0 % for naproxen and 10.3 % for celecoxib (odds ratio [OR] 0.39, p = 0.004 and OR 0.49, p = 0.03 for celecoxib versus ibuprofen and naproxen, respectively).

By inhibiting the COX - 2 enzyme, and consequently inhibiting interleukin - 17A, celecoxib could indirectly prevent macrophages from killing the injected stem cells and instead allow them to heal the wound.

Das and his colleagues hypothesized that celecoxib, a common anti-inflammatory drug that selectively inhibits the pro-inflammatory enzyme COX - 2, would improve stem cell survival and treatment outcomes for chronic wound therapy.

A significantly higher amount of stem cells had survived and integrated into the wound tissue in mice that had received celecoxib, and there were fewer inflammatory white blood cells and lower levels of cytokines in their wounds, including one cytokine called interleukin - 17A.

However, the mice treated using both celecoxib and stem cells showed better wound healing and more tissue growth a week later, compared with untreated mice or mice treated using stem cells or celecoxib alone.

They treated a third group orally using celecoxib, and the final group received celecoxib orally, as well as a stem cell injection into the skin near the wound.

The original erroneously stated that celecoxib is the generic name for Vioxx.

A landmark 2016 Cleveland Clinic study of widely used pain - relieving drugs showed that celecoxib (Celebrex) was associated with comparable cardiovascular safety and better gastrointestinal (GI) and kidney safety when compared...

The researchers also found diclofenac was better than the maximum doses of NSAIDs, including ibuprofen, naproxen (Aleve) and celecoxib (Celebrex).

In another published 12 - week human study, the combination of BCM - 95 curcumin and standardized boswellia (sometimes called frankincense) was compared to the generic of the prescription drug Celebrex (celecoxib) for osteoarthritis of the knee.

The researchers conducted a comprehensive analysis of 31 randomised controlled studies and 116,429 individuals using 7 different drugs (ibuprofen, naproxen, diclofenac, etoricoxib, celecoxib, lumiracoxib, rofecoxib) or placebo to give a more accurate picture of the cardiovascular safety of these drugs compared to previous research.

It appears to be comparable to celecoxib (an NSAID) with at least one study suggesting that the combination of boswellia and curcumin is

1,200 milligrams of S - adenosylmethionine daily, over the course of at least one month, is well studied and seems to be comparable to many pharmaceutical options like nabumetone, celecoxib, ibuprofen, indomethacin, naproxen.