Sentences with phrase «cell response in»

The researchers also found that a signaling protein called type I interferon controlled the difference in T cell response in mice with this mutant polyomavirus.

In contrast, we show here that the CD8 T cell response in chronically infected mice was dominated by only five epitopes.

Johannes Scheid, awarded for hos essay in the category Translational Medicine: «HIV Specific B cell Response in Patients with Broadly Neutralizing Serum Activity»

Evidence from these studies indicates that the use of mismatched MSC does not provoke a proliferative T cell response in allogeneic MLR, thus suggesting an immunosuppressive role for MSC 83, 84, 85, 86, 87, 88.

In a paper published online in Diabetes on January 26, biologists in the labs of Joslin Principal Investigator Rohit N. Kulkarni, M.D., Ph.D., and Anil Bhushan, Ph.D., at the University of California at Los Angeles used a genetic approach to show that a protein called cyclin D2 is needed for this beta - cell response in mice.

«We have no information on whether PD - 1 signaling is a primary mechanism for silencing helper cells, so recovery of the CD4 + helper cell response in this instance provides some indirect evidence that PD - 1 signaling also impairs the helper cells,» Dr. Walker says.

Comparing the magnitude and characteristics of WNV - specific CD4 + T cell response in individuals of similar ages with either neuroinvasive disease or asymptomatic infection, the researchers found that, independent of age, individuals with neuroinvasive disease had higher numbers of WNV - specific CD4 + T cells.

And during the Skylab missions, which began in 1973, scientists saw decreased white - blood - cell responses in returning astronauts.

This included detailed comparisons between immune T cell responses in the lungs, spleen and blood.

Relative importance of rotavirus - specific effector and memory B cell responses in protection against challenge.

The decreased levels of neutralizing Abs to TMAdV in the researcher (1 ∶ 32) and a family member (1 ∶ 8) relative to those in infected titi monkeys (up to > 1 ∶ 512) are consistent with a recent study showing much higher levels of neutralizing antibodies in chimpanzees than in humans with adenovirus infections, possibly due to more robust adenovirus - specific T - cell responses in humans than in monkeys [45].

The method became widely used to dissect T cell responses in vivo.

I would like to understand how S. pneumoniae stimulates T cell responses in mice and how those different mechanisms contribute to pulmonary disease.

The Dellabona / Casorati lab investigates T cell responses in tumor immunosurveillance and immunotherapy, by combining a variety of approaches in pre-clinical and clinical models.

Daniel Speiser, Pedro Romero, and colleauges report the first demonstration in humans that a synthetic vaccine can rapidly elicit strong specific CD8 + T cell responses in a majority of patients.

We attempt to understand how the organisation of chromatin determines the epigenetic control of T cell responses in vitro and in vivo.

Using JanusMatrix, we have identified T cell epitopes in H7N9 influenza HA protein that are highly conserved with human genome epitopes, and these epitopes possess low immunogenicity, activate natural Tregs and suppress bystander effector T cell responses in vitro.

IgDiscover uncovers genetic diversity in the immunoglobulin loci at the individual level, enabling an improved understanding of protective and pathogenic B cell responses in a variety of settings and facilitating future personalized immunization strategies.

Antiviral NK cell responses in HIV infection: I. NK cell receptor genes as determinants of HIV resistance and progression to AIDS.

Titers of preexisting Ad5 neutralizing antibody did not affect the frequency and magnitude of T cell responses in prime - boost recipients but did affect the response rates in participants that received rAd5 alone.

Working with Dr. Weiskopf, we established a model of human dengue disease using HLA transgenic mouse strains, and characterized human dengue - specific CD8 + and CD4 + T - cell responses in natural infection as well as following vaccination.

As part of a large NIH - funded effort to develop immunotherapies for this allergy (the Inner City Asthma Consortium, or ICAC), the Sette lab has thus identified dominant epitopes to characterize T cell responses in allergic individuals before and after immunotherapy.

To study the effect of ageing on the ability of CMV - specific CD8 (+) T cells to produce type 1 - and type 2 - cytokines, interferon - gamma - and IL -10-producing, CD8 (+) T cell responses in the presence of CMV peptide antigen were measured in CMV - seropositive old and young donors.

Comprehensive analysis of West Nile virus T cell responses in human infection.

Our studies have revealed a critical role for CD8 T - cell responses in dengue vaccine - mediated protection, and showed that the vaccine - induced antibody response can mediate ADE.

Odunsi K, Qian F, Matsuzaki J, Mhawech - Fauceglia P, Andrews C, Hoffman EW, Pan L. Ritter G, Villella J, Thomas B, Rodabaugh K, Lele S, Shrikant P, Old LJ, Gnjatic S. (2007) Vaccination with an NY - ESO - 1 peptide of HLA class I / II specificities induces integrated humoral and T cell responses in ovarian cancer.

Inhaled Glutathione for Lung Inflammation, Pneumonia, Emphysema Glutathione reduces oxidative stress, decreases inflammation, and modulates T cell responses in lungs.

RNA - loaded CD40 - B derived from canine peripheral blood B cells stimulate functional, antigen - specific T cell responses in vitro from healthy dogs and from dogs with spontaneously occurring NHL [12].

Not exact matches

Interleukin - 1 is important for developing the killer T cell response against the virus, but it also affects the part of the brain in the hypothalamus that regulates body temperature, resulting in fever and headaches.

KTE - C19 spurred either a complete or partial response in 13 out of 19 patients with large B - cell lymphomas.

Consider Chan Zuckerberg's Biohub, which is embracing big hairy audacious projects like mapping every cell in the human body (with university partners Berkeley, Stanford, and UCSF) and developing a «universal diagnostic test» and rapid - response team for emerging pathogens.

In December, SQZ partnered with global pharma firm and cancer treatment leader F. Hoffmann - La Roche in a deal that could be worth $ 500 million or more — a large undisclosed upfront payment, and additional sums when SQZ meets certain milestones — to speed up the development of its technology specifically to inject a person's immune cells with a protein to activate a «killer T» cell response to fight off canceIn December, SQZ partnered with global pharma firm and cancer treatment leader F. Hoffmann - La Roche in a deal that could be worth $ 500 million or more — a large undisclosed upfront payment, and additional sums when SQZ meets certain milestones — to speed up the development of its technology specifically to inject a person's immune cells with a protein to activate a «killer T» cell response to fight off cancein a deal that could be worth $ 500 million or more — a large undisclosed upfront payment, and additional sums when SQZ meets certain milestones — to speed up the development of its technology specifically to inject a person's immune cells with a protein to activate a «killer T» cell response to fight off cancer.

About half of the patients in a Kymriah study got cytokine - release syndrome, a response to the reprogrammed cells running loose in the body.

During a raid, officers with the jail's Direct Action Response Team clear out inmates from sections of the jail, frisk them, and turn over their cells in search of the contraband.

The company leverages its unique insights in cancer biology and the immune system to discover and develop novel oral small molecules that activate immune responses to eliminate cancer cells.

The biotech specialist said that its updated phase 2 data in a study of its poziotinib candidate treatment for non-small cell lung cancer resulted in a preliminary confirmed objective response rate and potential progression - free survival benefit in patients with the EGFR Exon 20 Mutant form of the disease.

The tattooing process works by injecting ink into the skin, which stimulates an immune response in which cells called «macrophages» move into the area and «eat up» the ink.

Referring to Plato's depiction of a «world soul» in the Timaeus, Hartshorne posits that just as people have a mutual relationship of response and reaction between the cells of their body and themselves, there is a similar mutual relationship of feeling between God and cell - like elements within the world: atoms, cells, people.

Our thanks to all who wrote in response to our political history of stem cells.

Not surprisingly, President Obama received high marks from the journal, largely because his response to the question of whether he would lift Bush's ban on the federal funding of new embryonic stem - cell lines is in line with the view of most in the scientific community.

Looking people in the eye, listening to what they have to say and making an intelligent response that lets them know we really heard what they were saying, not acting like we're in a hurry to move on but have time to listen, letting them know they are more important than our stupid cell phones, encouraging them and letting them know we think they can succeed — all of those things are extremely important in building relationships, including relationships with homeless people.

My aim to strike an «e» — or even to type a complete word «the» triggers a burst of physical responses in my brain cells, which in turn mediate these «amplified» feelings to adjacent occasions in other brain cells and in neurons.

Turnips are high in vitamins A and C; antioxidants that together play an important role in stimulating the body's immune response by boosting the formation of antibodies and white blood cells.

In addition, Red Star Nutritional Yeast contains other beneficial components, such as beta - 1,3 glucan and mannan, complex carbohydrates known to improve the immune response and help maintain cholesterol levels that are already within a healthy range; trehalose, a disaccharide that helps maintain the health of brain cells; and glutathione, an antioxidant that plays an important role in cellular defense mechanismIn addition, Red Star Nutritional Yeast contains other beneficial components, such as beta - 1,3 glucan and mannan, complex carbohydrates known to improve the immune response and help maintain cholesterol levels that are already within a healthy range; trehalose, a disaccharide that helps maintain the health of brain cells; and glutathione, an antioxidant that plays an important role in cellular defense mechanismin cellular defense mechanisms.

It also boosts the body's immune response against infections and cancer cells and plays an important role in thyroid function and fertility.

Hormones produced by the body in response to sugar consumption also feed cancer cells.

No observed local immunological response at cell level after five years of oats in adult coeliac disease.

CD4 cells (also known as T4 or helper T cells) are lymphocytes (a type of white blood cell), which are important in immune responses.

According the the Mayo Clinic, it helps in two different ways: 1) It has anti-inflammatory properties that inhibit the circulation of neutrophils — cells that participate in the body's inflammatory response.

In addition, selective probiotics, like bifidobacterium, can increase IgA secretion (40) as well as indirectly enhance T regulatory cell activity (18), thereby promoting mucosal tolerance and preventing the allergic response.